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B-Cell Epitope Mapping of the Vibrio cholera Toxins A, B, and P and an ELISA Assay.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Dec 28; Vol. 24 (1). Date of Electronic Publication: 2022 Dec 28.
Abstract: Oral immunization with the choleric toxin (CT) elicits a high level of protection against its enterotoxin activities and can control cholera in endemic settings. However, the complete B-cell epitope map of the CT that is responsible for protection rema...
Altered molecular attributes and antimicrobial resistance patterns of Vibrio cholerae O1 El Tor strains isolated from the cholera endemic regions of India.
Publication Type: Academic Journal
Source(s): Journal of applied microbiology [J Appl Microbiol] 2022 Dec; Vol. 133 (6), pp. 3605-3616. Date of Electronic Publication: 2022 Sep 07.
Abstract: Aims: The present study aimed to document the comparative analysis of differential hypervirulent features of Vibrio cholerae O1 strains isolated during 2018 from cholera endemic regions in Gujarat and Maharashtra (Western India) and West Bengal (Easter...
Inactivated Vibrio cholerae Strains That Express TcpA via the toxT -139F Allele Induce Antibody Responses against TcpA.
Publication Type: Academic Journal
Source(s): Journal of microbiology and biotechnology [J Microbiol Biotechnol] 2022 Nov 28; Vol. 32 (11), pp. 1396-1405. Date of Electronic Publication: 2022 Oct 12.
Abstract: Cholera remains a major global public health problem, for which oral cholera vaccines (OCVs) being a valuable strategy. Patients, who have recovered from cholera, develop antibody responses against LPS, cholera toxin (CT), toxin-coregulated pilus (TCP)...
A polyvalent multiepitope protein cross-protects against Vibrio cholerae infection in rabbit colonization and passive protection models.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Dec 13; Vol. 119 (50), pp. e2202938119. Date of Electronic Publication: 2022 Dec 05.
Abstract: Using epitope- and structure-based multiepitope fusion antigen vaccinology platform, we constructed a polyvalent protein immunogen that presents antigenic domains (epitopes) of Vibrio cholerae toxin-coregulated pilus A, cholera toxin (CT), sialidase, h...
Long-term sialidase-specific immune responses after natural infection with cholera: Findings from a longitudinal cohort study in Bangladesh.
Publication Type: Academic Journal
Source(s): Frontiers in immunology [Front Immunol] 2022 Dec 22; Vol. 13, pp. 1067737. Date of Electronic Publication: 2022 Dec 22 (Print Publication: 2022).
Abstract: Background: Immune responses that target sialidase occur following natural cholera and have been associated with protection against cholera. Sialidase is a neuraminidase that facilitates the binding of cholera toxin (CT) to intestinal epithelial cells....
Cholera in Haiti, Again.
Publication Type: Academic Journal
Source(s): The New England journal of medicine [N Engl J Med] 2022 Dec 22; Vol. 387 (25), pp. 2300-2301. Date of Electronic Publication: 2022 Nov 30.
Metagenomic analysis of diarrheal stools in Kolkata, India, indicates the possibility of subclinical infection of Vibrio cholerae O1.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2022 Nov 14; Vol. 12 (1), pp. 19473. Date of Electronic Publication: 2022 Nov 14.
Abstract: We examined the stools of 23 patients in Kolkata, who were diagnosed as cholera patients because Vibrio cholerae O1 was detected from their stools by culturing methods, and further explored by metagenomic sequencing analysis. Subsequently, the presence...
Occurrence of waterborne pathogens and antibiotic resistance in water supply systems in a small town in Mozambique.
Publication Type: Academic Journal
Source(s): BMC microbiology [BMC Microbiol] 2022 Oct 08; Vol. 22 (1), pp. 243. Date of Electronic Publication: 2022 Oct 08.
Abstract: Background: . Microbiological quality of drinking water supplied in Moamba, a small town in southern Mozambique, was assessed by collecting and analyzing 91 water sample from 5 sampling sites: raw or inlet water, treated water and 3 household taps alon...
In Vitro and In Vivo Inhibitory Activities of Selected Traditional Medicinal Plants against Toxin-Induced Cyto- and Entero- Toxicities in Cholera.
Publication Type: Academic Journal
Source(s): Toxins [Toxins (Basel)] 2022 Sep 20; Vol. 14 (10). Date of Electronic Publication: 2022 Sep 20.
Abstract: Careya arborea , Punica granatum , Psidium guajava , Holarrhena antidysenterica , Aegle marmelos , and Piper longum are commonly used traditional medicines against diarrhoeal diseases in India. This study investigated the inhibitory activity of these p...
Phage defence by deaminase-mediated depletion of deoxynucleotides in bacteria.
Publication Type: Academic Journal
Source(s): Nature microbiology [Nat Microbiol] 2022 Aug; Vol. 7 (8), pp. 1210-1220. Date of Electronic Publication: 2022 Jul 11.
Abstract: Vibrio cholerae biotype El Tor is perpetuating the longest cholera pandemic in recorded history. The genomic islands VSP-1 and VSP-2 distinguish El Tor from previous pandemic V. cholerae strains. Using a co-occurrence analysis of VSP genes in >200,000 ...