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Advanced Search Results For "CLINICAL trials"

1 - 10 of 592,365 results for
 "CLINICAL trials"
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Demonstrating Benefit-Risk Profiles of Novel Therapeutic Strategies in Kidney Transplantation: Opportunities and Challenges of Real-World Evidence.

Publication Type:Academic Journal

Source(s):Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2022 May 03; Vol. 35, pp. 10329. Date of Electronic Publication: 2022 May 03 (Print Publication: 2022).

Abstract:While great progress has been made in transplantation medicine, long-term graft failure and serious side effects still pose a challenge in kidney transplantation. Effective and safe long-term treatments are needed. Therefore, evidence of the lasting be...

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Practical and robust test for comparing binomial proportions in the randomized phase II setting.

Publication Type:Academic Journal

Source(s):Pharmaceutical statistics [Pharm Stat] 2022 Mar; Vol. 21 (2), pp. 361-371. Date of Electronic Publication: 2021 Oct 09.

Abstract:The one-arm, non-randomized, one/two-stage phase II designs have been a mainstay in oncology trials for evaluating response rates or similar variants (i.e., tests about single proportions). With the goal of screening new therapies that have the potenti...

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Design and reporting of interventional clinical trials.

Source(s):Nature communications [Nat Commun] 2022 Feb 17; Vol. 13 (1), pp. 990. Date of Electronic Publication: 2022 Feb 17.

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The status and outcomes of registered clinical trials for Janus kinase inhibitors in alopecia areata: are unpublished trials being overlooked?

Publication Type:Academic Journal

Source(s):Clinical and experimental dermatology [Clin Exp Dermatol] 2021 Oct; Vol. 46 (7), pp. 1290-1292. Date of Electronic Publication: 2021 Jul 14.

Abstract:Recent meta-analyses of Janus kinase (JAK) inhibitors in alopecia areata (AA) have excluded trial registries and may thus be subject to publication bias. This study assessed the potential for evidence selection bias and provides an overview of JAK inhi...

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Clinical trials in urological oncology: COVID-19 and the potential need for a new perspective.

Publication Type:Academic Journal

Source(s):World journal of urology [World J Urol] 2021 Sep; Vol. 39 (9), pp. 3147-3149. Date of Electronic Publication: 2020 Sep 04.

Abstract:The COVID-19 pandemic has led to the suspension, termination or alteration of thousands of clinical trials as the health emergency escalated globally. Whilst the rapid suspension of certain clinical trials was necessary to ensure the safety of high-ris...

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Collaborative Platform Trials to Fight COVID-19: Methodological and Regulatory Considerations for a Better Societal Outcome.

Publication Type:Academic Journal

Source(s):Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Aug; Vol. 110 (2), pp. 311-320. Date of Electronic Publication: 2021 Mar 16.

Abstract:For the development of coronavirus disease 2019 (COVID-19) drugs during the ongoing pandemic, speed is of essence whereas quality of evidence is of paramount importance. Although thousands of COVID-19 trials were rapidly started, many are unlikely to p...

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Melanoma trials that defined surgical management.

Publication Type:Academic Journal

Source(s):Journal of surgical oncology [J Surg Oncol] 2022 Jan; Vol. 125 (1), pp. 34-37.

Abstract:Treatment of regional lymph nodes in melanoma has been controversial for more than a century. A series of clinical trials evaluating elective lymph node dissection and then sentinel lymph node biopsy have helped define the current standard of care. The...

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Clarifying the role of clinical research nurses working in Sweden, using the Clinical Trial Nursing Questionnaire - Swedish version.

Publication Type:Academic Journal

Source(s):Nursing open [Nurs Open] 2022 Sep; Vol. 9 (5), pp. 2434-2443. Date of Electronic Publication: 2022 Jun 02.

Abstract:Aim: To explore the role of CRNs in Sweden and differences in competences and tasks, using the Clinical Trial Nursing Questionnaire - Swedish version (CTNQ-SWE).Design: A cross-sectional survey.Methods: Participants were identified through strategic sa...

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