Advanced Search Results For "CLINICAL trials"
Your filters
Safety and efficacy of post-haematopoietic cell transplantation maintenance therapy with blinatumomab for relapsed/refractory CD19-positive B-cell acute lymphoblastic leukaemia: protocol for a phase I-II, multicentre, non-blinded, non-controlled trial (JPLSG SCT-ALL-BLIN21).
Publication Type: Academic Journal
Source(s): BMJ open [BMJ Open] 2023 Apr 17; Vol. 13 (4), pp. e070051. Date of Electronic Publication: 2023 Apr 17.
Abstract: Introduction: Relapsed and refractory B-cell acute lymphoblastic leukaemia (R/R-B-ALL) is linked to a significant relapse rate after allogeneic haematopoietic cell transplantation (allo-HCT) in children, adolescents and young adults (CAYA). No standard...
Ensuring the Scientific Value and Feasibility of Clinical Trials: A Qualitative Interview Study.
Publication Type: Academic Journal
Source(s): AJOB empirical bioethics [AJOB Empir Bioeth] 2023 Apr-Jun; Vol. 14 (2), pp. 99-110. Date of Electronic Publication: 2023 Jan 04.
Abstract: Background: Ethical and scientific principles require that clinical trials address an important question and have the resources needed to complete the study. However, there are no clear standards for review that would ensure that these principles are u...
Not enough SPIRIT shown in the registration and reporting of orthodontic trial protocols.
Publication Type: Academic Journal
Source(s): European journal of orthodontics [Eur J Orthod] 2023 Feb 10; Vol. 45 (1), pp. 29-37.
Abstract: Background: To reduce bias associated with selective reporting, the registration and publication of clinical trial protocols before or at the time of patient enrolment has been advocated. The aim of this investigation was to assess the frequency of reg...
Recording and reporting of recruitment strategies in trial protocols, registries, and publications was nonexistent.
Publication Type: Academic Journal
Source(s): Journal of clinical epidemiology [J Clin Epidemiol] 2022 Dec; Vol. 152, pp. 248-256. Date of Electronic Publication: 2022 Oct 20.
Abstract: Objectives: To investigate how trialists record and report their recruitment strategies and the recruiter details in trial protocols, registries, and publications.Study Design and Setting: A retrospective study of ovarian cancer (OC) trials between 201...
The unblinding of statisticians in clinical trials: commentary on Iflaifel et al., Trials 2023.
Publication Type: Editorial & Opinion
Source(s): Trials [Trials] 2023 Sep 11; Vol. 24 (1), pp. 579. Date of Electronic Publication: 2023 Sep 11.
Abstract: Recently, the Blinding of Trial Statisticians research team, Iflaifel and colleagues, have produced detailed guidance regarding the blinding or unblinding of statisticians in clinical trials, based on substantial mixed-methods work. I wish to comment o...
Seamless phase II/III design: a useful strategy to reduce the sample size for dose optimization.
Publication Type: Academic Journal
Source(s): Journal of the National Cancer Institute [J Natl Cancer Inst] 2023 Sep 07; Vol. 115 (9), pp. 1092-1098.
Abstract: Background: The traditional more-is-better dose selection paradigm, originally developed for cytotoxic chemotherapeutics, can be problematic when applied to the development of novel molecularly targeted agents. Recognizing this issue, the US Food and D...
A rank-based approach to improve the efficiency of inferential seamless phase 2/3 clinical trials with dose optimization.
Publication Type: Academic Journal
Source(s): Contemporary clinical trials [Contemp Clin Trials] 2023 Sep; Vol. 132, pp. 107300. Date of Electronic Publication: 2023 Jul 17.
Abstract: To accelerate clinical development, seamless 2/3 adaptive design is an attractive strategy to combine phase 2 dose selection with phase 3 confirmatory objectives. As the regulatory requirement for dose optimization in oncology drugs shifted from maximu...
Adapting a clinical decision support system to improve identification of pediatric hypertension in a rural health system: Design of a pragmatic trial.
Publication Type: Academic Journal
Source(s): Contemporary clinical trials [Contemp Clin Trials] 2023 Sep; Vol. 132, pp. 107293. Date of Electronic Publication: 2023 Jul 16.
Abstract: Background: Identifying hypertension (HTN) early is crucial in preventing and lowering the long-term risk of heart disease, yet HTN in children often goes undiagnosed. An electronic health record linked, web-based clinical decision support (CDS) called...
Health system-scale language models are all-purpose prediction engines.
Publication Type: Academic Journal
Source(s): Nature [Nature] 2023 Jul; Vol. 619 (7969), pp. 357-362. Date of Electronic Publication: 2023 Jun 07.
Abstract: Physicians make critical time-constrained decisions every day. Clinical predictive models can help physicians and administrators make decisions by forecasting clinical and operational events. Existing structured data-based clinical predictive models ha...
Factors influencing the quality of acupuncture clinical trials: a qualitative interview of stakeholders.
Publication Type: Academic Journal
Source(s): BMC complementary medicine and therapies [BMC Complement Med Ther] 2023 Sep 16; Vol. 23 (1), pp. 326. Date of Electronic Publication: 2023 Sep 16.
Abstract: Objective: To investigate the influencing factors on the quality of acupuncture clinical trials from the stakeholders, and to provide references for improving the quality of acupuncture clinical trials.Methods: A qualitative study based on semi-structu...