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Advanced Search Results For "COLONIES"

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 "COLONIES"
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Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis.

Publication Type:Academic Journal

Source(s):Journal for immunotherapy of cancer [J Immunother Cancer] 2022 Sep; Vol. 10 (9).

Abstract:Background: Immune checkpoint inhibitor (ICI)-related pneumonitis is the most frequent fatal immune-related adverse event associated with programmed cell death protein-1/programmed death ligand-1 blockade. The pathophysiology however remains largely un...

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G-CSF/GM-CSF-induced hematopoietic dysregulation in the progression of solid tumors.

Publication Type:Academic Journal

Source(s):FEBS open bio [FEBS Open Bio] 2022 Jul; Vol. 12 (7), pp. 1268-1285. Date of Electronic Publication: 2022 Jun 09.

Abstract:There are two types of abnormal hematopoiesis in solid tumor occurrence and treatment: pathological hematopoiesis, and myelosuppression induced by radiotherapy and chemotherapy. In this review we primarily focus on the abnormal pathological hematopoiet...

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[ 11 C]NCGG401, a novel PET ligand for imaging of colony stimulating factor 1 receptors.

Publication Type:Academic Journal

Source(s):Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Jun 01; Vol. 65, pp. 128704. Date of Electronic Publication: 2022 Mar 26.

Abstract:Colony-stimulating factor 1 receptors (CSF1R) are expressed exclusively on microglia in the central nervous system. The receptors regulate immune responses by controlling the survival and activity of microglia and are intricately involved in the pathop...

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Targeting IL-34/MCSF-1R Axis in Colon Cancer.

Publication Type:Academic Journal

Source(s):Frontiers in immunology [Front Immunol] 2022 Jun 28; Vol. 13, pp. 917955. Date of Electronic Publication: 2022 Jun 28 (Print Publication: 2022).

Abstract:Colorectal carcinoma (CRC) is one of the most common neoplasias in the Western world and it is still one of the most deadly cancers worldwide mainly due to the fact that metastatic CRC is not responsive to current pharmacologic treatment. Identificatio...

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Evaluating serum level of granulocyte, macrophage and granulocyte-macrophage colony-stimulating factors in patients with breast tumor.

Publication Type:Academic Journal

Source(s):Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 2022 May 31; Vol. 68 (5), pp. 146-152. Date of Electronic Publication: 2022 May 31.

Abstract:Colony-stimulating factors (CSFs) are glycoproteins that stimulate the proliferation and differentiation of hematopoietic progenitor cells in the bone marrow. But numerous studies have shown that these factors can stimulate the proliferation of non-hem...

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GM-CSF: A Double-Edged Sword in Cancer Immunotherapy.

Publication Type:Academic Journal

Source(s):Frontiers in immunology [Front Immunol] 2022 Jul 05; Vol. 13, pp. 901277. Date of Electronic Publication: 2022 Jul 05 (Print Publication: 2022).

Abstract:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that drives the generation of myeloid cell subsets including neutrophils, monocytes, macrophages, and dendritic cells in response to stress, infections, and cancers. By modulating ...

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The Role of Zinc in GM-CSF-Induced Signaling in Human Polymorphonuclear Leukocytes.

Publication Type:Academic Journal

Source(s):Molecular nutrition & food research [Mol Nutr Food Res] 2022 Jul; Vol. 66 (14), pp. e2101106. Date of Electronic Publication: 2022 May 31.

Abstract:Scope: Zinc is suggested to be necessary for functional signaling induced by certain growth factors. The granulocyte-macrophage colony-stimulating factor (GM-CSF) is a key factor for differentiation and activation of myeloid cells. This report analyses...

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CSF1/CSF1R signaling mediates malignant pleural effusion formation.

Publication Type:Academic Journal

Source(s):JCI insight [JCI Insight] 2022 Mar 22; Vol. 7 (6). Date of Electronic Publication: 2022 Mar 22.

Abstract:Malignant pleural effusion (MPE) is an incurable common manifestation of many malignancies. Its formation is orchestrated by complex interactions among tumor cells, inflammatory cells, and the vasculature. Tumor-associated macrophages present the domin...

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CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation.

Publication Type:Academic Journal

Source(s):Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Apr 05; Vol. 119 (14), pp. e2111804119. Date of Electronic Publication: 2022 Mar 30.

Abstract:The receptor for colony stimulating factor 1 (CSF-1R) is important for the survival and function of myeloid cells that mediate pathology during experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). CSF-1 and IL-34...

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Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids.

Publication Type:Academic Journal

Source(s):Cartilage [Cartilage] 2022 Jan-Mar; Vol. 13 (1), pp. 19476035221081469.

Abstract:Objective: Folate receptor beta (FR-β) has been used as a clinical marker and target in multiple inflammatory diseases, including osteoarthritis (OA) and rheumatoid arthritis (RA). However, the conditions under which FR-β + macrophages arise remain unc...

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