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Advanced Search Results For "COMETS"

1 - 10 of 21,778 results for
 "COMETS"
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Short- and long-term reproducibility of the COMET assay for measuring DNA damage biomarkers in frozen blood samples of the EPIC-Heidelberg cohort.

Publication Type:Academic Journal

Source(s):Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2022 Feb-Mar; Vol. 874-875, pp. 503442. Date of Electronic Publication: 2022 Jan 12.

Abstract:The comet assay is widely used for quantification of genomic damage in humans. Peripheral blood derived mononuclear cells (PBMCs) are the most often used cell type for this purpose. Since the comet assay can be performed in an enhanced throughput forma...

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Comet Assay for the Detection of Single and Double-Strand DNA Breaks.

Publication Type:Academic Journal

Source(s):Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2422, pp. 263-269.

Abstract:DNA damage is a common event that occurs during the life span of the majority of cells, as a result of aberrant energy metabolism, exposure to radiation, DNA damaging chemicals, and viral infections. Rapid, sensitive, and economical methods for the det...

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Niosome-carvedilol protects DNA damage of supraphysiologic concentrations of insulin using comet assay: An in vitro study.

Publication Type:Academic Journal

Source(s):Human & experimental toxicology [Hum Exp Toxicol] 2021 Dec; Vol. 40 (12_suppl), pp. S150-S157. Date of Electronic Publication: 2021 Jul 31.

Abstract:Introduction: Hyperinsulinemia occurs in type 2 diabetic patients with insulin resistance. This increase in insulin levels in the blood increases reactive oxygen species production and oxidative stress, resulting in DNA damage. Carvedilol (CRV) is a no...

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Cell survival after DNA damage in the comet assay.

Publication Type:Academic Journal

Source(s):Archives of toxicology [Arch Toxicol] 2021 Dec; Vol. 95 (12), pp. 3803-3813. Date of Electronic Publication: 2021 Oct 05.

Abstract:The comet assay is widely used in basic research, genotoxicity testing, and human biomonitoring. However, interpretation of the comet assay data might benefit from a better understanding of the future fate of a cell with DNA damage. DNA damage is in pr...

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Lack of mutagenicity of TiO 2 nanoparticles in vitro despite cellular and nuclear uptake.

Publication Type:Academic Journal

Source(s):Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2022 Oct; Vol. 882, pp. 503545. Date of Electronic Publication: 2022 Sep 05.

Abstract:The potential genotoxicity of titanium dioxide (TiO 2 ) nanoparticles (NPs) is a conflictive topic because both positive and negative findings have been reported. To add clarity, we have carried out a study with two cell lines (V79-4 and A549) to evalu...

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Comparison of the genotoxicity of two commercial pesticides by their micro and nano size capsules.

Publication Type:Academic Journal

Source(s):Toxicology and industrial health [Toxicol Ind Health] 2022 Oct; Vol. 38 (10), pp. 675-686. Date of Electronic Publication: 2022 Aug 31.

Abstract:The use of nanotechnology in the agrochemical industry has become increasingly popular over the past decade, raising the question of whether these products may represent a risk or benefit compared to their conventional presentations. In this study, we ...

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In vitro evaluation of zearalenone toxicity by comet assay.

Publication Type:Academic Journal

Source(s):Polish journal of veterinary sciences [Pol J Vet Sci] 2022 Sep; Vol. 25 (3), pp. 475-477.

Abstract:The aim of this study was to reveal the potentially genotoxic effect of zearalenone on bovine lymphocytes by comet assay in vitro. The bovine lymphocytes were exposed to various zearalenone concetrations (50; 10; 2; 0.4 and 0.08 ppm). The viability and...

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Protective effect of chrysin, a flavonoid, on the genotoxic activity of carboplatin in mice.

Publication Type:Academic Journal

Source(s):Drug and chemical toxicology [Drug Chem Toxicol] 2022 Sep; Vol. 45 (5), pp. 2146-2152. Date of Electronic Publication: 2021 Apr 08.

Abstract:Carboplatin is amongst the most commonly used anticancer drugs for the management of several human malignancies. However, it has displayed genotoxic properties against normal cells. Evaluation of natural products for their protective effects against ch...

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Evaluating nanobiomaterial-induced DNA strand breaks using the alkaline comet assay.

Publication Type:Academic Journal

Source(s):Drug delivery and translational research [Drug Deliv Transl Res] 2022 Sep; Vol. 12 (9), pp. 2243-2258. Date of Electronic Publication: 2022 May 25.

Abstract:Due to their unique chemical and physical properties, nanobiomaterials (NBMs) are extensively studied for applications in medicine and drug delivery. Despite these exciting properties, their small sizes also make them susceptible to toxicity. Whilst na...

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Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?

Publication Type:Academic Journal

Source(s):Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2022 Sep; Vol. 881, pp. 503520. Date of Electronic Publication: 2022 Jun 23.

Abstract:The comet assay is used to measure DNA damage induced by chemical and physical agents. High concentrations of test agents may cause cytotoxicity or cell death, which may give rise to false positive results in the comet assay. Systematic studies on geno...

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