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An engineered recombinant protein containing three structural domains in SARS-CoV-2 S2 protein has potential to act as a pan-human coronavirus entry inhibitor or vaccine antigen.
Publication Type: Academic Journal
Source(s): Emerging microbes & infections [Emerg Microbes Infect] 2023 Dec; Vol. 12 (2), pp. 2244084.
Abstract: The threat to global health caused by three highly pathogenic human coronaviruses (HCoV), SARS-CoV-2, MERS-CoV and SARS-CoV, calls for the development of pan-HCoV therapeutics and vaccines. This study reports the design and engineering of a recombinant...
Evolution of the coronavirus spike protein in the full-length genome and defective viral genome under diverse selection pressures.
Publication Type: Academic Journal
Source(s): The Journal of general virology [J Gen Virol] 2023 Nov; Vol. 104 (11).
Abstract: How coronaviruses evolve by altering the structures of their full-length genome and defective viral genome (DVG) under dynamic selection pressures has not been studied. In this study, we aimed to experimentally identify the dynamic evolutionary pattern...
Codon usage bias analysis of the spike protein of human coronavirus 229E and its host adaptability.
Publication Type: Academic Journal
Source(s): International journal of biological macromolecules [Int J Biol Macromol] 2023 Dec 31; Vol. 253 (Pt 6), pp. 127319. Date of Electronic Publication: 2023 Oct 09.
Abstract: Human coronavirus 229E (HCoV-229E) represents one of the known coronaviruses capable of infecting humans and causes mild respiratory symptoms. It is also considered to have a zoonotic source, originating from animals and being transmitted the humans. I...
Revealing Novel-Strain-Specific and Shared Epitopes of Infectious Bronchitis Virus Spike Glycoprotein Using Chemical Linkage of Peptides onto Scaffolds Precision Epitope Mapping.
Publication Type: Academic Journal
Source(s): Viruses [Viruses] 2023 Nov 20; Vol. 15 (11). Date of Electronic Publication: 2023 Nov 20.
Abstract: The avian coronavirus, infectious bronchitis virus (IBV), is an economically important infectious disease affecting chickens, with a diverse range of serotypes found globally. The major surface protein, spike (S), has high diversity between serotypes, ...
Designing peptides predicted to bind to the omicron variant better than ACE2 via computational protein design and molecular dynamics.
Publication Type: Academic Journal
Source(s): PloS one [PLoS One] 2023 Oct 10; Vol. 18 (10), pp. e0292589. Date of Electronic Publication: 2023 Oct 10 (Print Publication: 2023).
Abstract: Brought about by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease (COVID-19) pandemic has resulted in large numbers of worldwide deaths and cases. Several SARS-CoV-2 variants have evolved, and Omicron (B.1.1.529) was on...
MERS-CoV and SARS-CoV-2 membrane proteins are modified with polylactosamine chains.
Publication Type: Academic Journal
Source(s): The Journal of general virology [J Gen Virol] 2023 Oct; Vol. 104 (10).
Abstract: Coronaviruses are positive-stranded RNA enveloped viruses. The helical nucleocapsid is surrounded by a lipid bilayer in which are anchored three viral proteins: the spike (S), membrane (M) and envelope (E) proteins. The M protein is the major component...
Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddings.
Publication Type: Academic Journal
Source(s): Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 24-35.
Abstract: Ligand-based drug design methods are thought to require large experimental datasets to become useful for virtual screening. In this work, we propose a computational strategy to design novel inhibitors of coronavirus main protease, M pro . The pipeline ...
Spike Gene Analysis and Prevalence of Porcine Epidemic Diarrhea Virus from Pigs in South Korea: 2013-2022.
Publication Type: Academic Journal
Source(s): Viruses [Viruses] 2023 Oct 28; Vol. 15 (11). Date of Electronic Publication: 2023 Oct 28.
Abstract: From late 2013-2022, 1131 cases of porcine epidemic diarrhea (PED) were reported to the Korean Animal Health Integrated System (KAHIS). There were four major outbreaks from winter to spring (2013-2014, 2017-2018, 2018-2019, and 2021-2022), with the mai...
Unraveling DPP4 Receptor Interactions with SARS-CoV-2 Variants and MERS-CoV: Insights into Pulmonary Disorders via Immunoinformatics and Molecular Dynamics.
Publication Type: Academic Journal
Source(s): Viruses [Viruses] 2023 Oct 06; Vol. 15 (10). Date of Electronic Publication: 2023 Oct 06.
Abstract: Human coronaviruses like MERS CoV are known to utilize dipeptidyl peptidase 4 (DPP4), apart from angiotensin-converting enzyme 2(ACE2) as a potential co-receptor for viral cell entry. DPP4, the ubiquitous membrane-bound aminopeptidase, is closely assoc...
Potent immunogenicity and broad-spectrum protection potential of microneedle array patch-based COVID-19 DNA vaccine candidates encoding dimeric RBD chimera of SARS-CoV and SARS-CoV-2 variants.
Publication Type: Academic Journal
Source(s): Emerging microbes & infections [Emerg Microbes Infect] 2023 Dec; Vol. 12 (1), pp. 2202269.
Abstract: Breakthrough infections by SARS-CoV-2 variants pose a global challenge to COVID-19 pandemic control, and the development of more effective vaccines of broad-spectrum protection is needed. In this study, we constructed pVAX1-based plasmids encoding rece...