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Rationale for combining tyrosine kinase inhibitors and T cell redirecting antibodies to mitigate cytokine release syndrome (CRS).
Publication Type: Editorial & Opinion
Source(s): Expert opinion on biological therapy [Expert Opin Biol Ther] 2023 Mar; Vol. 23 (3), pp. 223-225. Date of Electronic Publication: 2023 Jan 29.
Zymosan Particle-Induced Hemodynamic, Cytokine and Blood Cell Changes in Pigs: An Innate Immune Stimulation Model with Relevance to Cytokine Storm Syndrome and Severe COVID-19.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jan 06; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 06.
Abstract: Hemodynamic disturbance, a rise in neutrophil-to-lymphocyte ratio (NLR) and release of inflammatory cytokines into blood, is a bad prognostic indicator in severe COVID-19 and other diseases involving cytokine storm syndrome (CSS). The purpose of this s...
Huashibaidu formula attenuates sepsis-induced acute lung injury via suppressing cytokine storm: Implications for treatment of COVID-19.
Publication Type: Academic Journal
Source(s): Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2023 Jan; Vol. 109, pp. 154549. Date of Electronic Publication: 2022 Nov 19.
Abstract: Background: Acute lung injury (ALI) is a common complication of sepsis with poor effective interventions. Huashibaidu formula (HSBD) showed good therapeutic effects in treating coronavirus disease 2019 (COVID-19) patients.Purpose: This study was design...
The Role of Cytokines in the Metastasis of Solid Tumors to the Spine: Systematic Review.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Feb 14; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 14.
Abstract: Although many studies have investigated the role of cytokines in bone metastases, our knowledge of their function in spine metastasis is limited. Therefore, we performed a systematic review to map the available evidence on the involvement of cytokines ...
Risk factors of cytokine release syndrome: stress, catecholamines, and beyond.
Publication Type: Academic Journal
Source(s): Trends in immunology [Trends Immunol] 2023 Feb; Vol. 44 (2), pp. 93-100. Date of Electronic Publication: 2022 Dec 30.
Abstract: Cytokine release syndrome (CRS) is a severe clinical syndrome marked by drastic elevation of inflammatory cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF). Despite the current empirical therapeutic strategies, prediction of C...
Emerging principles of cytokine pharmacology and therapeutics.
Publication Type: Academic Journal
Source(s): Nature reviews. Drug discovery [Nat Rev Drug Discov] 2023 Jan; Vol. 22 (1), pp. 21-37. Date of Electronic Publication: 2022 Sep 21.
Abstract: Cytokines are secreted signalling proteins that play essential roles in the initiation, maintenance and resolution of immune responses. Although the unique ability of cytokines to control immune function has garnered clinical interest in the context of...
Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis.
Publication Type: Academic Journal
Source(s): Science translational medicine [Sci Transl Med] 2023 Mar 22; Vol. 15 (688), pp. eabq2395. Date of Electronic Publication: 2023 Mar 22.
Abstract: Adult mammals are incapable of multitissue regeneration, and augmentation of this potential may shift current therapeutic paradigms. We found that a common co-receptor of interleukin 6 (IL-6) cytokines, glycoprotein 130 (gp130), serves as a major nexus...
Inflammation balance in skeletal muscle damage and repair.
Publication Type: Academic Journal
Source(s): Frontiers in immunology [Front Immunol] 2023 Jan 26; Vol. 14, pp. 1133355. Date of Electronic Publication: 2023 Jan 26 (Print Publication: 2023).
Abstract: Responding to tissue injury, skeletal muscles undergo the tissue destruction and reconstruction accompanied with inflammation. The immune system recognizes the molecules released from or exposed on the damaged tissue. In the local minor tissue damage, ...
Immunophenotype and antitumor activity of cytokine-induced killer cells from patients with hepatocellular carcinoma.
Publication Type: Academic Journal
Source(s): PloS one [PLoS One] 2023 Jan 04; Vol. 18 (1), pp. e0280023. Date of Electronic Publication: 2023 Jan 04 (Print Publication: 2023).
Abstract: Background: Cytokine-induced killer (CIK) cells are heterogeneous lymphocytes from human peripheral blood mononucleated cells (PBMCs) co-cultured with several cytokines. The main purpose of this study is to evaluate the functional characteristics and a...
Cytokine Release Syndrome in the Pediatric Population and Implications for Intensive Care Management.
Publication Type: Academic Journal
Source(s): Critical care clinics [Crit Care Clin] 2023 Apr; Vol. 39 (2), pp. 277-285. Date of Electronic Publication: 2022 Nov 18.
Abstract: Cytokine release syndrome represents a spectrum of disease varying from fever alone to multiorgan system failure. Most commonly seen following treatment with chimeric antigen receptor T cell therapy, it is increasingly being described with other immuno...