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Aspergillus Niger thermostable Cytosine deaminase-dextran conjugates with enhanced structure stability, proteolytic resistance, and Antiproliferative activity.
Publication Type: Academic Journal
Source(s): BMC microbiology [BMC Microbiol] 2023 Jan 10; Vol. 23 (1), pp. 9. Date of Electronic Publication: 2023 Jan 10.
Abstract: Cytosine deaminase (CDA) is a prodrug mediating enzyme converting 5-flurocytosine into 5-flurouracil with profound broad-range anticancer activity towards various cell lines. Availability, molecular stability, and catalytic efficiency are the main limi...
In situ sequence-specific visualization of single methylated cytosine on tissue sections using ICON probe and rolling-circle amplification.
Publication Type: Academic Journal
Source(s): Histochemistry and cell biology [Histochem Cell Biol] 2023 Mar; Vol. 159 (3), pp. 263-273. Date of Electronic Publication: 2022 Nov 23.
Abstract: Since epigenetic modifications differ from cell to cell, detecting the DNA methylation status of individual cells is requisite. Therefore, it is important to conduct "morphology-based epigenetics research", in which the sequence-specific DNA methylatio...
TadA orthologs enable both cytosine and adenine editing of base editors.
Publication Type: Academic Journal
Source(s): Nature communications [Nat Commun] 2023 Jan 26; Vol. 14 (1), pp. 414. Date of Electronic Publication: 2023 Jan 26.
Abstract: Cytidine and adenosine deaminases are required for cytosine and adenine editing of base editors respectively, and no single deaminase could enable concurrent and comparable cytosine and adenine editing. Additionally, distinct properties of cytidine and...
Poly cytosine (C)/poly adenine (A) modified probe for signal "on-off-on" assay of single-base mismatched dsDNA by a competitive mechanism.
Publication Type: Academic Journal
Source(s): Analytica chimica acta [Anal Chim Acta] 2023 Jan 25; Vol. 1239, pp. 340705. Date of Electronic Publication: 2022 Dec 07.
Abstract: Direct discrimination of single-base mismatched dsDNA by a simple method or strategy would provide enormous opportunities for applications in the fields of life sciences and disease diagnosis. Herein, the peroxidase-mimicking activity of a metal-organi...
Efficient CRISPR-Cas9 based cytosine base editors for phytopathogenic bacteria.
Publication Type: Academic Journal
Source(s): Communications biology [Commun Biol] 2023 Jan 17; Vol. 6 (1), pp. 56. Date of Electronic Publication: 2023 Jan 17.
Abstract: Phytopathogenic bacteria play important roles in plant productivity, and developments in gene editing have potential for enhancing the genetic tools for the identification of critical genes in the pathogenesis process. CRISPR-based genome editing varia...
Development of QM/MM (ABEEM polarizable force field) method to simulate the excision reaction mechanism of damaged cytosine.
Publication Type: Academic Journal
Source(s): Journal of computational chemistry [J Comput Chem] 2022 Dec 15; Vol. 43 (32), pp. 2139-2153. Date of Electronic Publication: 2022 Sep 24.
Abstract: DNA damages are regarded as having harmful effects on cell. The base excision repair mechanism combats these effects by removing damaged bases. The deglycosylation mechanism of excising damaged bases by DNA glycosylase and the state of the leaving base...
5-Formylcytosine weakens the G-C pair and imparts local conformational fluctuations to DNA duplexes.
Publication Type: Academic Journal
Source(s): Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2022 Dec 21; Vol. 25 (1), pp. 241-254. Date of Electronic Publication: 2022 Dec 21.
Abstract: DNA epigenetic modifications such as 5-methyl ( 5m C), 5-hydroxymethyl ( 5hm C), 5-formyl ( 5f C) and 5-carboxyl ( 5ca C) cytosine have unique and specific biological roles. Crystallographic studies of 5m C containing duplexes were conducted in the A-,...
Generalized Energy-Based Fragmentation Approach for the Electronic Emission Spectra of Large Systems.
Publication Type: Academic Journal
Source(s): Journal of chemical theory and computation [J Chem Theory Comput] 2022 Dec 13; Vol. 18 (12), pp. 7630-7638. Date of Electronic Publication: 2022 Nov 18.
Abstract: The excited-state (ES) geometry optimization and electronic emission (fluorescence and phosphorescence) spectra and the ES vibrational spectra of large systems are great challenges in quantum chemistry. In this work, we develop a generalized energy-bas...
An insight into embryogenesis interruption by carbon nitride dots: can they be nucleobase analogs?
Publication Type: Academic Journal
Source(s): Nanoscale [Nanoscale] 2022 Dec 08; Vol. 14 (47), pp. 17607-17624. Date of Electronic Publication: 2022 Dec 08.
Abstract: The carbon nitride dot (CND) is an emerging carbon-based nanomaterial. It possesses rich surface functional moieties and a carbon nitride core. Spectroscopic data have demonstrated the analogy between CNDs and cytosine/uracil. Recently, it was found th...
Quantum mechanics/molecular mechanics studies on excited state decay pathways of 5-azacytosine in aqueous solution.
Publication Type: Academic Journal
Source(s): Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2022 Nov 23; Vol. 24 (45), pp. 27793-27803. Date of Electronic Publication: 2022 Nov 23.
Abstract: In this work, we have used the QM(CASPT2//CASSCF)/MM approach to study the photophysical properties and relaxation mechanism of 5-azacytosine (5-AC) in aqueous solution. Based on the relevant minimum-energy structures and intersection structures, and e...