Advanced Search Results For "Carboxypeptidase B genetics"
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Endoplasmic stress-inducing variants in CPB1 and CPA1 and risk of pancreatic cancer: A case-control study and meta-analysis.
Publication Type: Academic Journal
Source(s): International journal of cancer [Int J Cancer] 2022 Apr 01; Vol. 150 (7), pp. 1123-1133. Date of Electronic Publication: 2021 Dec 06.
Abstract: Gene variants that encode pancreatic enzymes with impaired secretion can induce pancreatic acinar endoplasmic reticulum (ER) stress, cellular injury and pancreatitis. The role of such variants in pancreatic cancer risk has received little attention. We...
Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism.
Publication Type: Academic Journal
Source(s): Protein science : a publication of the Protein Society [Protein Sci] 2021 Dec; Vol. 30 (12), pp. 2445-2456. Date of Electronic Publication: 2021 Nov 05.
Abstract: Metallocarboxypeptidases (MCPs) in the mosquito midgut play crucial roles in infection, as well as in mosquito dietary digestion, reproduction, and development. MCPs are also part of the digestive system of plant-feeding insects, representing key targe...
Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 May 01; Vol. 115 (18), pp. 4767-4772. Date of Electronic Publication: 2018 Apr 18.
Abstract: To evaluate whether germline variants in genes encoding pancreatic secretory enzymes contribute to pancreatic cancer susceptibility, we sequenced the coding regions of CPB1 and other genes encoding pancreatic secretory enzymes and known pancreatitis su...
Malaria Box Compounds against Anopheles gambiae (Diptera: Culicidae) Carboxypeptidase B Activity to Block Malaria Transmission.
Publication Type: Academic Journal
Source(s): Journal of medical entomology [J Med Entomol] 2022 Jul 13; Vol. 59 (4), pp. 1355-1362.
Abstract: Carboxypeptidase B (CPB) plays an important role in blood digestion in mosquitos, aiding the release of free amino acids. Anopheles CPB is a target to block malaria transmission because it facilitates Plasmodium invasion of the mosquito midgut. Our stu...
Limited proteolysis by a prostatic endopeptidase, the sperm-activating factor initiatorin, regulates the activation of pro-carboxypeptidase B in the seminal fluid of the silkworm, Bombyx mori.
Publication Type: Academic Journal
Source(s): Insect biochemistry and molecular biology [Insect Biochem Mol Biol] 2022 Sep; Vol. 148, pp. 103819. Date of Electronic Publication: 2022 Aug 11.
Abstract: A prostate trypsin-like serine endopeptidase called initiatorin (BmIni) is an essential factor in triggering the sperm maturation response of the silkworm, Bombyx mori. BmIni has been predicted to specifically cleave the carboxyl side of two consecutiv...
Structure of Aedes aegypti procarboxypeptidase B1 and its binding with Dengue virus for controlling infection.
Publication Type: Academic Journal
Source(s): Life science alliance [Life Sci Alliance] 2021 Nov 08; Vol. 5 (1). Date of Electronic Publication: 2021 Nov 08 (Print Publication: 2022).
Abstract: Metallocarboxypeptidases play critical roles in the development of mosquitoes and influence pathogen/parasite infection of the mosquito midgut. Here, we report the crystal structure of Aedes aegypti procarboxypeptidase B1 (PCPBAe1), characterized its s...
Molecular characterization of carboxypeptidase B-like (CPB) in Scylla paramamosain and its role in white spot syndrome virus and Vibrio alginolyticus infection.
Publication Type: Academic Journal
Source(s): Fish & shellfish immunology [Fish Shellfish Immunol] 2019 Nov; Vol. 94, pp. 434-446. Date of Electronic Publication: 2019 Sep 16.
Abstract: Carboxypeptidase plays an important physiological role in the tissues and organs of animals. In this study, we cloned an entire 2316 bp carboxypeptidase B-like (CPB) sequence with a 1302 bp open reading frame encoding a 434 amino acid peptide from Scyl...
Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.
Publication Type: Academic Journal
Source(s): American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2015 Oct 15; Vol. 309 (8), pp. G688-94. Date of Electronic Publication: 2015 Aug 27.
Abstract: Genetic alterations in the carboxypeptidase A1 gene (CPA1) are associated with early onset chronic pancreatitis (CP). Besides CPA1, there are two other human pancreatic carboxypeptidases (CPA2 and CPB1). Here we examined whether CPA2 and CPB1 alteratio...
Crystal structure of mutant carboxypeptidase T from Thermoactinomyces vulgaris with an implanted S1' subsite from pancreatic carboxypeptidase B.
Publication Type: Academic Journal
Source(s): Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2018 Oct 01; Vol. 74 (Pt 10), pp. 638-643. Date of Electronic Publication: 2018 Sep 19.
Abstract: A site-directed mutagenesis method has been used to obtain the G215S/A251G/T257A/D260G/T262D mutant of carboxypeptidase T from Thermoactinomyces vulgaris (CPT), in which the amino-acid residues of the S1' subsite are substituted by the corresponding re...
Peroxisome proliferator-activated receptor-alpha agonists repress expression of thrombin-activatable fibrinolysis inhibitor by decreasing transcript stability.
Publication Type: Academic Journal
Source(s): Thrombosis and haemostasis [Thromb Haemost] 2012 Jul; Vol. 108 (1), pp. 74-85. Date of Electronic Publication: 2012 Apr 26.
Abstract: Thrombin-activatable fibrinolysis inhibitor (TAFI) (carboxypeptidase B2) is a plasma zymogen that is biosynthesised in the liver and released into the circulation. Activated TAFI is a prothrombotic factor which inhibits fibrin clot lysis. Cultured huma...