Advanced Search Results For "Carboxypeptidase B metabolism"
Your filters
Limited proteolysis by a prostatic endopeptidase, the sperm-activating factor initiatorin, regulates the activation of pro-carboxypeptidase B in the seminal fluid of the silkworm, Bombyx mori.
Publication Type: Academic Journal
Source(s): Insect biochemistry and molecular biology [Insect Biochem Mol Biol] 2022 Sep; Vol. 148, pp. 103819. Date of Electronic Publication: 2022 Aug 11.
Abstract: A prostate trypsin-like serine endopeptidase called initiatorin (BmIni) is an essential factor in triggering the sperm maturation response of the silkworm, Bombyx mori. BmIni has been predicted to specifically cleave the carboxyl side of two consecutiv...
Antibody charge variant modulation by in vitro enzymatic treatment in different Chinese hamster ovary cell cultures.
Publication Type: Academic Journal
Source(s): Biotechnology progress [Biotechnol Prog] 2022 Sep; Vol. 38 (5), pp. e3268. Date of Electronic Publication: 2022 May 24.
Abstract: Charge variants represent a critical quality attribute that must be controlled during the development and manufacturing of monoclonal antibodies (mAb). Previously, we reported the development of a cost-effective enzymatic treatment capable of removing ...
Structure of Aedes aegypti procarboxypeptidase B1 and its binding with Dengue virus for controlling infection.
Publication Type: Academic Journal
Source(s): Life science alliance [Life Sci Alliance] 2021 Nov 08; Vol. 5 (1). Date of Electronic Publication: 2021 Nov 08 (Print Publication: 2022).
Abstract: Metallocarboxypeptidases play critical roles in the development of mosquitoes and influence pathogen/parasite infection of the mosquito midgut. Here, we report the crystal structure of Aedes aegypti procarboxypeptidase B1 (PCPBAe1), characterized its s...
Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism.
Publication Type: Academic Journal
Source(s): Protein science : a publication of the Protein Society [Protein Sci] 2021 Dec; Vol. 30 (12), pp. 2445-2456. Date of Electronic Publication: 2021 Nov 05.
Abstract: Metallocarboxypeptidases (MCPs) in the mosquito midgut play crucial roles in infection, as well as in mosquito dietary digestion, reproduction, and development. MCPs are also part of the digestive system of plant-feeding insects, representing key targe...
Malaria Box Compounds against Anopheles gambiae (Diptera: Culicidae) Carboxypeptidase B Activity to Block Malaria Transmission.
Publication Type: Academic Journal
Source(s): Journal of medical entomology [J Med Entomol] 2022 Jul 13; Vol. 59 (4), pp. 1355-1362.
Abstract: Carboxypeptidase B (CPB) plays an important role in blood digestion in mosquitos, aiding the release of free amino acids. Anopheles CPB is a target to block malaria transmission because it facilitates Plasmodium invasion of the mosquito midgut. Our stu...
Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 May 01; Vol. 115 (18), pp. 4767-4772. Date of Electronic Publication: 2018 Apr 18.
Abstract: To evaluate whether germline variants in genes encoding pancreatic secretory enzymes contribute to pancreatic cancer susceptibility, we sequenced the coding regions of CPB1 and other genes encoding pancreatic secretory enzymes and known pancreatitis su...
Pancreatic Tissue Proteomics Unveils Key Proteins, Pathways, and Networks Associated with Type 1 Diabetes.
Publication Type: Academic Journal
Source(s): Proteomics. Clinical applications [Proteomics Clin Appl] 2020 Nov; Vol. 14 (6), pp. e2000053. Date of Electronic Publication: 2020 Oct 14.
Abstract: Purpose: Type 1 diabetes (T1D) is characterized by autoimmune mediated self-destruction of the pancreatic islet beta cells and the resultant insulin deficiency. However, little is known about the underlying molecular pathogenesis at the pancreatic tiss...
Phosphorylation of carboxypeptidase B1 protein regulates β-cell proliferation.
Publication Type: Academic Journal
Source(s): International journal of molecular medicine [Int J Mol Med] 2017 Nov; Vol. 40 (5), pp. 1397-1404. Date of Electronic Publication: 2017 Sep 19.
Abstract: A reduction in pancreatic islet β-cells leads to the onset of diabetes. Hence, the identification of the mechanisms inducing β-cell proliferation is important for developing a treatment course against the disease. It has been well established that post...
Carboxypeptidase B-Assisted Charge-Based Fractional Diagonal Chromatography for Deep Screening of C-Terminome.
Publication Type: Academic Journal
Source(s): Analytical chemistry [Anal Chem] 2020 Jun 16; Vol. 92 (12), pp. 8005-8009. Date of Electronic Publication: 2020 May 28.
Abstract: The determination of protein C-termini is of great significance for protein function annotation and proteolysis research. However, the progress of C-terminomics is still far behind its counterpart, N-terminomics, because of the low reactivity of the ca...
Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients.
Publication Type: Academic Journal
Source(s): Critical care (London, England) [Crit Care] 2021 Feb 08; Vol. 25 (1), pp. 51. Date of Electronic Publication: 2021 Feb 08.
Abstract: Background: Thrombosis and coagulopathy are highly prevalent in critically ill patients with COVID-19 and increase the risk of death. Immunothrombosis has recently been demonstrated to contribute to the thrombotic events in COVID-19 patients with coagu...