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Advanced Search Results For "Carboxypeptidases A genetics"

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 "Carboxypeptidases A genetics"
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Novel p.G250A Mutation Associated with Chronic Pancreatitis Highlights Misfolding-Prone Region in Carboxypeptidase A1 (CPA1).

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Dec 07; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 07.

Abstract: Inborn mutations in the digestive protease carboxypeptidase A1 (CPA1) gene may be associated with hereditary and idiopathic chronic pancreatitis (CP). Pathogenic mutations, such as p.N256K, cause intracellular retention and reduced secretion of CPA1, a...

Endoplasmic stress-inducing variants in CPB1 and CPA1 and risk of pancreatic cancer: A case-control study and meta-analysis.

Publication Type: Academic Journal

Source(s): International journal of cancer [Int J Cancer] 2022 Apr 01; Vol. 150 (7), pp. 1123-1133. Date of Electronic Publication: 2021 Dec 06.

Abstract: Gene variants that encode pancreatic enzymes with impaired secretion can induce pancreatic acinar endoplasmic reticulum (ER) stress, cellular injury and pancreatitis. The role of such variants in pancreatic cancer risk has received little attention. We...

Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop.

Publication Type: Academic Journal

Source(s): Scientific reports [Sci Rep] 2022 Apr 15; Vol. 12 (1), pp. 6357. Date of Electronic Publication: 2022 Apr 15.

Abstract: Genetic mutations in pancreatic digestive enzymes may cause protein misfolding, endoplasmic reticulum (ER) stress and chronic pancreatitis. The CPA1 N256K mouse model carries the human p.N256K carboxypeptidase A1 (CPA1) mutation, a classic example of a...

Serum Carboxypeptidase Activity and Genotype-Stratified CA19-9 to Detect Early-Stage Pancreatic Cancer.

Publication Type: Academic Journal

Source(s): Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2022 Oct; Vol. 20 (10), pp. 2267-2275.e2. Date of Electronic Publication: 2021 Oct 12.

Abstract: Background and Aims: Serum diagnostic markers of early-stage pancreatic ductal adenocarcinoma (PDAC) are needed, especially for stage I disease. As tumors grow and cause pancreatic atrophy, markers derived from pancreatic parenchyma such as serum carbo...

Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism.

Publication Type: Academic Journal

Source(s): Protein science : a publication of the Protein Society [Protein Sci] 2021 Dec; Vol. 30 (12), pp. 2445-2456. Date of Electronic Publication: 2021 Nov 05.

Abstract: Metallocarboxypeptidases (MCPs) in the mosquito midgut play crucial roles in infection, as well as in mosquito dietary digestion, reproduction, and development. MCPs are also part of the digestive system of plant-feeding insects, representing key targe...

Anabaenopeptins from Nostoc edaphicum CCNP1411.

Publication Type: Academic Journal

Source(s): International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Sep 28; Vol. 19 (19). Date of Electronic Publication: 2022 Sep 28.

Abstract: Cyanobacteria of the Nostoc genus belong to the most prolific sources of bioactive metabolites. In our previous study on Nostoc edaphicum strain CCNP1411, the occurrence of cyanopeptolins and nostocyclopeptides was documented. In the current work, the ...

Four differentially expressed genes can predict prognosis and microenvironment immune infiltration in lung cancer: a study based on data from the GEO.

Publication Type: Academic Journal

Source(s): BMC cancer [BMC Cancer] 2022 Feb 21; Vol. 22 (1), pp. 193. Date of Electronic Publication: 2022 Feb 21.

Authors:

Abstract: Background: Lung cancer is among the major diseases threatening human health. Although the immune response plays an important role in tumor development, its exact mechanisms are unclear.Materials and Methods: Here, we used CIBERSORT and ESTIMATE algori...

Carboxypeptidase A6 was identified and validated as a novel potential biomarker for predicting the occurrence of active ulcerative colitis.

Publication Type: Academic Journal

Source(s): Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Aug; Vol. 24 (15), pp. 8803-8813. Date of Electronic Publication: 2020 Jun 22.

Authors:

Abstract: Ulcerative colitis (UC) is a chronic, highly heterogeneous intestinal inflammation with changes in epithelial function and tissue damage. However, the pathogenesis is still unclear between active UC and inactive UC. Herein, weighted gene co-expression ...

Predicted gene 31453 (Gm31453) and the gene encoding carboxypeptidase A5 (Cpa5) are not essential for spermatogenesis and male fertility in the mouse.

Publication Type: Academic Journal

Source(s): Reproduction, fertility, and development [Reprod Fertil Dev] 2021 Apr; Vol. 33 (6), pp. 401-409.

Abstract: Numerous long non-coding (lnc) RNAs are highly enriched or exclusively expressed in the mammalian testis, even in spermatids. Spermatid perinuclear RNA-binding protein (STRBP) can bind many RNAs, and loss of STRBP impairs male fertility. However, the f...

Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice.

Publication Type: Academic Journal

Source(s): American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2020 Apr 01; Vol. 318 (4), pp. G694-G704. Date of Electronic Publication: 2020 Mar 02.

Abstract: Alcoholic pancreatitis is a multifactorial, progressive, inflammatory disorder of the pancreas. Alcohol initiates pancreatitis and promotes its progression in the context of genetic susceptibility and/or other environmental risk factors such as smoking...

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