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Advanced Search Results For "Carboxypeptidases A metabolism"

1 - 10 of 1,336 results for
 "Carboxypeptidases A metabolism"
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Anabaenopeptins from Nostoc edaphicum CCNP1411.

Publication Type: Academic Journal

Source(s): International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Sep 28; Vol. 19 (19). Date of Electronic Publication: 2022 Sep 28.

Abstract: Cyanobacteria of the Nostoc genus belong to the most prolific sources of bioactive metabolites. In our previous study on Nostoc edaphicum strain CCNP1411, the occurrence of cyanopeptolins and nostocyclopeptides was documented. In the current work, the ...

RNA-Seq unveiled section-specific host response to lack of gut microbiota in mouse intestine.

Publication Type: Academic Journal

Source(s): Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2021 Dec 15; Vol. 433, pp. 115775. Date of Electronic Publication: 2021 Oct 26.

Abstract: To identify host responses induced by commensal microbiota in intestine, transcriptomes of four sections of the intestine were compared between germ-free (GF) mice and conventional (CV) controls using RNA-Seq. Cuffdiff revealed that jejunum had the hig...

Plasma biomarkers TAP, CPA1, and CPA2 for the detection of pancreatic injury in rat: the development of a novel multiplex IA-LC-MS/MS assay and biomarker performance evaluation.

Publication Type: Academic Journal

Source(s): Archives of toxicology [Arch Toxicol] 2023 Mar; Vol. 97 (3), pp. 769-785. Date of Electronic Publication: 2022 Dec 08.

Abstract: Drug-induced pancreatic injury (DIPI) is an issue seen in drug development both in nonclinical and clinical contexts. DIPI is typically monitored by measurement of lipase and/or amylase, however, both enzymes lack sensitivity and specificity. Although ...

Enhanced carboxypeptidase efficacies and differentiation of peptide epimers.

Publication Type: Academic Journal

Source(s): Analytical biochemistry [Anal Biochem] 2022 Apr 01; Vol. 642, pp. 114451. Date of Electronic Publication: 2021 Nov 11.


Abstract: Carboxypeptidases enzymatically cleave the peptide bond of C-terminal amino acids. In humans, it is involved in enzymatic synthesis and maturation of proteins and peptides. Carboxypeptidases A and Y have difficulty hydrolyzing the peptide bond of dipep...

Misfolding-induced chronic pancreatitis in CPA1 N256K mutant mice is unaffected by global deletion of Ddit3/Chop.

Publication Type: Academic Journal

Source(s): Scientific reports [Sci Rep] 2022 Apr 15; Vol. 12 (1), pp. 6357. Date of Electronic Publication: 2022 Apr 15.

Abstract: Genetic mutations in pancreatic digestive enzymes may cause protein misfolding, endoplasmic reticulum (ER) stress and chronic pancreatitis. The CPA1 N256K mouse model carries the human p.N256K carboxypeptidase A1 (CPA1) mutation, a classic example of a...

Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism.

Publication Type: Academic Journal

Source(s): Protein science : a publication of the Protein Society [Protein Sci] 2021 Dec; Vol. 30 (12), pp. 2445-2456. Date of Electronic Publication: 2021 Nov 05.

Abstract: Metallocarboxypeptidases (MCPs) in the mosquito midgut play crucial roles in infection, as well as in mosquito dietary digestion, reproduction, and development. MCPs are also part of the digestive system of plant-feeding insects, representing key targe...

Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate.

Publication Type: Academic Journal

Source(s): Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2019 Oct 22; Vol. 518 (4), pp. 651-656. Date of Electronic Publication: 2019 Aug 26.

Abstract: Angiotensin processing peptidases (carboxypeptidase A (CPA) and chymase) are stored in cardiac mast cell (MC) secretory granules in large quantity and are co-released into the extracellular environment after activation/degranulation. In the human heart...

Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin.

Publication Type: Academic Journal

Source(s): Journal of leukocyte biology [J Leukoc Biol] 2021 Sep; Vol. 110 (3), pp. 425-431. Date of Electronic Publication: 2021 May 31.

Abstract: The immune response plays a critical role in the pathophysiology of SARS-CoV-2 infection ranging from protection to tissue damage and all occur in the development of acute respiratory distress syndrome (ARDS). ARDS patients display elevated levels of i...

Carboxypeptidase A4 negatively correlates with p53 expression and regulates the stemness of breast cancer cells.

Publication Type: Academic Journal

Source(s): International journal of medical sciences [Int J Med Sci] 2021 Feb 18; Vol. 18 (8), pp. 1753-1759. Date of Electronic Publication: 2021 Feb 18 (Print Publication: 2021).


Abstract: Background: Triple-negative breast cancer (TNBC) is an aggressive cancer subtype lacking effective treatment options, and p53 is the most frequently mutated or deleted gene. Carboxypeptidase A4 (CPA4) is an extracellular metallocarboxypeptidase, which ...

Predicted gene 31453 (Gm31453) and the gene encoding carboxypeptidase A5 (Cpa5) are not essential for spermatogenesis and male fertility in the mouse.

Publication Type: Academic Journal

Source(s): Reproduction, fertility, and development [Reprod Fertil Dev] 2021 Apr; Vol. 33 (6), pp. 401-409.

Abstract: Numerous long non-coding (lnc) RNAs are highly enriched or exclusively expressed in the mammalian testis, even in spermatids. Spermatid perinuclear RNA-binding protein (STRBP) can bind many RNAs, and loss of STRBP impairs male fertility. However, the f...