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New Insights into the Diverse Functions of the NR2F Nuclear Orphan Receptor Family.
Publication Type: Academic Journal
Source(s): Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2023 Jan 17; Vol. 28 (1), pp. 13.
Abstract: Following gene expansion during evolution, today's phylogenetic tree of the NR2F family of nuclear orphan receptors in mammals is represented by three different isoforms: NR2F1, NR2F2, and NR2F6. Structural analysis of the NR2F family members has revea...
Tungsten toxicity and carcinogenesis.
Publication Type: Academic Journal
Source(s): Advances in pharmacology (San Diego, Calif.) [Adv Pharmacol] 2023; Vol. 96, pp. 119-150. Date of Electronic Publication: 2022 Dec 20.
Abstract: Tungsten is an emerging contaminant in the environment. Research has demonstrated that humans are exposed to high levels of tungsten in certain settings, primarily due to increased use of tungsten in industrial applications. However, our understanding ...
Identification of specific susceptibility loci for the early-onset colorectal cancer.
Publication Type: Academic Journal
Source(s): Genome medicine [Genome Med] 2023 Mar 03; Vol. 15 (1), pp. 13. Date of Electronic Publication: 2023 Mar 03.
Abstract: Background: The incidence of early-onset colorectal cancer (EOCRC; patients < 50 years old) has been rising rapidly, whereas the EOCRC genetic susceptibility remains incompletely investigated. Here, we aimed to systematically identify specific suscepti...
Hidden tricks in MATH: Hypermorphic mutations in SPOP tumor suppressor explained by cryo-EM.
Publication Type: Academic Journal
Source(s): Molecular cell [Mol Cell] 2023 Mar 02; Vol. 83 (5), pp. 655-656.
Abstract: Loss-of-function mutations in SPOP E3 ubiquitin ligase drive multiple cancers. However, carcinogenic gain-of-function SPOP mutations have been a major puzzle. In this issue of Molecular Cell, Cuneo et al. 1 show that several mutations map to SPOP oligo...
Maestros of malignancy: Microbes as the conductors of carcinogenesis.
Publication Type: Report
Source(s): Neoplasia (New York, N.Y.) [Neoplasia] 2023 Mar; Vol. 37, pp. 100887. Date of Electronic Publication: 2023 Feb 14.
Abstract: Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper entitled: “Maestros of Mali...
Sag/Rbx2 Partial Inactivation Sensitizes Mice to Radiation and Radiation-Induced Tumorigenesis1.
Publication Type: Academic Journal
Source(s): Radiation research [Radiat Res] 2023 Mar 01; Vol. 199 (3), pp. 273-282.
Abstract: SAG (sensitive to apoptosis gene)/RBX2 (RING box-2), is the second family member of RING component of cullin-RING ligase (CRL) complex required for its enzymatic activity. Using total or conditional Sag knockout mouse models, we previously showed that ...
Modeling cancer's ecological and evolutionary dynamics.
Publication Type: Academic Journal
Source(s): Medical oncology (Northwood, London, England) [Med Oncol] 2023 Feb 28; Vol. 40 (4), pp. 109. Date of Electronic Publication: 2023 Feb 28.
Abstract: In this didactic paper, we present a theoretical modeling framework, called the G-function, that integrates both the ecology and evolution of cancer to understand oncogenesis. The G-function has been used in evolutionary ecology, but has not been widel...
The molecular link between obesity and genomic instability in cancer development.
Publication Type: Academic Journal
Source(s): Cancer letters [Cancer Lett] 2023 Feb 28; Vol. 555, pp. 216035. Date of Electronic Publication: 2022 Dec 09.
Abstract: Obesity has been known to be a major risk factor for various types of cancers for several decades. More recently, the relationship between dysregulated adipokines and cancer development has been the focus of much research. Adipose tissue is an importan...
Uncoupling Metastasis from Tumorigenesis.
Publication Type: Academic Journal
Source(s): The New England journal of medicine [N Engl J Med] 2023 Feb 16; Vol. 388 (7), pp. 657-659.
Multiple characteristic alterations and available therapeutic strategies of cellular senescence.
Publication Type: Academic Journal
Source(s): Journal of Zhejiang University. Science. B [J Zhejiang Univ Sci B] 2023 Feb 15; Vol. 24 (2), pp. 101-114.
Abstract: Given its state of stable proliferative inhibition, cellular senescence is primarily depicted as a critical mechanism by which organisms delay the progression of carcinogenesis. Cells undergoing senescence are often associated with the alteration of a ...