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The exocyst complex is required for the trafficking and delivery of KCa3.1 to the basolateral membrane of polarized epithelia.
Publication Type: Academic Journal
Source(s): American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2023 Jun 01; Vol. 324 (6), pp. C1249-C1262. Date of Electronic Publication: 2023 May 01.
Abstract: Control of the movement of ions and water across epithelia is essential for homeostasis. Changing the number or activity of ion channels at the plasma membrane is a significant regulator of epithelial transport. In polarized epithelia, the intermediate...
Multiple plasma membrane reporters discern LHFPL5 region that blocks trafficking to the plasma membrane.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2023 Feb 13; Vol. 13 (1), pp. 2528. Date of Electronic Publication: 2023 Feb 13.
Abstract: The mechano-electrical transduction (MET) channel of the inner ear receptor cells, termed hair cells, is a protein complex that enables our senses of hearing and balance. Hair cell MET requires an elaborate interplay of multiple proteins that form the ...
Dynamic localization of the Na+-HCO3- co-transporter NBCn1 to the plasma membrane, centrosomes, spindle and primary cilia.
Publication Type: Academic Journal
Source(s): Journal of cell science [J Cell Sci] 2023 Apr 01; Vol. 136 (7). Date of Electronic Publication: 2023 Apr 11.
Abstract: Finely tuned regulation of transport protein localization is vital for epithelial function. The Na+-HCO3- co-transporter NBCn1 (also known as SLC4A7) is a key contributor to epithelial pH homeostasis, yet the regulation of its subcellular localization ...
The trajectory patterns of single HIV-1 virus-like particle in live CD4 cells: A real time three-dimensional multi-resolution microscopy study using encapsulated nonblinking giant quantum dot.
Publication Type: Academic Journal
Source(s): Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [J Microbiol Immunol Infect] 2023 Apr; Vol. 56 (2), pp. 257-266. Date of Electronic Publication: 2022 Aug 28.
Abstract: Background: The exploration of virology knowledge was limited by the optical technology for the observation of virus. Previously, a three-dimensional multi-resolution real-time microscope system (3D-MRM) was developed to observe the uptake of HIV-1-tat...
Glycolipid transfer protein knockout disrupts vesicle trafficking to the plasma membrane.
Publication Type: Academic Journal
Source(s): The Journal of biological chemistry [J Biol Chem] 2023 Apr; Vol. 299 (4), pp. 104607. Date of Electronic Publication: 2023 Mar 15.
Abstract: The glycolipid transfer protein (GLTP) has been linked to many cellular processes aside from its best-known in vitro function as a lipid transport protein. It has been proposed to act as a sensor and regulator of glycosphingolipid homeostasis in cells....
Recruitment of clathrin to intracellular membranes is sufficient for vesicle formation.
Publication Type: Academic Journal
Source(s): ELife [Elife] 2022 Jul 19; Vol. 11. Date of Electronic Publication: 2022 Jul 19.
Abstract: The formation of a clathrin-coated vesicle (CCV) is a major membrane remodeling process that is crucial for membrane traffic in cells. Besides clathrin, these vesicles contain at least 100 different proteins although it is unclear how many are essentia...
DeepContact: High-throughput quantification of membrane contact sites based on electron microscopy imaging.
Publication Type: Academic Journal
Source(s): The Journal of cell biology [J Cell Biol] 2022 Sep 05; Vol. 221 (9). Date of Electronic Publication: 2022 Aug 05.
Abstract: Membrane contact site (MCS)-mediated organelle interactions play essential roles in the cell. Quantitative analysis of MCSs reveals vital clues for cellular responses under various physiological and pathological conditions. However, an efficient tool i...
Linked Chemotype Cellular Uptake Is Facilitated by IFITMs.
Publication Type: Academic Journal
Source(s): Cancer discovery [Cancer Discov] 2023 Feb 06; Vol. 13 (2), pp. 259.
Abstract: Interferon-induced transmembrane proteins (IFITM) modulate cell permeability of diverse linked chemotypes. (©2023 American Association for Cancer Research.)
Orientation of the Dysferlin C2A Domain is Responsive to the Composition of Lipid Membranes.
Publication Type: Academic Journal
Source(s): The journal of physical chemistry. B [J Phys Chem B] 2023 Jan 19; Vol. 127 (2), pp. 577-589. Date of Electronic Publication: 2023 Jan 06.
Abstract: Dysferlin is a 230 kD protein that plays a critical function in the active resealing of micron-sized injuries to the muscle sarcolemma by recruiting vesicles to patch the injured site via vesicle fusion. Muscular dystrophy is observed in humans when mu...
Endoplasmic reticulum membrane contact sites: cross-talk between membrane-bound organelles in plant cells.
Publication Type: Academic Journal
Source(s): Journal of experimental botany [J Exp Bot] 2023 May 19; Vol. 74 (10), pp. 2956-2967.
Abstract: Eukaryotic cells contain organelles surrounded by monolayer or bilayer membranes. Organelles take part in highly dynamic and organized interactions at membrane contact sites, which play vital roles during development and response to stress. The endopla...