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The trajectory patterns of single HIV-1 virus-like particle in live CD4 cells: A real time three-dimensional multi-resolution microscopy study using encapsulated nonblinking giant quantum dot.
Publication Type: Academic Journal
Source(s): Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [J Microbiol Immunol Infect] 2023 Apr; Vol. 56 (2), pp. 257-266. Date of Electronic Publication: 2022 Aug 28.
Abstract: Background: The exploration of virology knowledge was limited by the optical technology for the observation of virus. Previously, a three-dimensional multi-resolution real-time microscope system (3D-MRM) was developed to observe the uptake of HIV-1-tat...
4D Force Detection of Cell Adhesion and Contractility.
Publication Type: Academic Journal
Source(s): Nano letters [Nano Lett] 2023 Apr 12; Vol. 23 (7), pp. 2467-2475. Date of Electronic Publication: 2023 Mar 28.
Abstract: Mechanical signals establish two-way communication between mammalian cells and their environment. Cells contacting a surface exert forces via contractility and transmit them at the areas of focal adhesions. External stimuli, such as compressive and pul...
Regulated rapid round trips: Endocytotic cycling of the dopamine transporter shapes motor learning.
Publication Type: Academic Journal
Source(s): The Journal of biological chemistry [J Biol Chem] 2023 Apr; Vol. 299 (4), pp. 104618. Date of Electronic Publication: 2023 Mar 17.
Abstract: The level of dopamine transporters (DATs) in the neuronal plasma membrane shapes learning and motor coordination in mice. Mechanisms underlying the regulated internalization of DAT and its return to the cell surface have been intensively studied in het...
The dynamic nature of exocytosis from large secretory vesicles. A view from electrochemistry and imaging.
Publication Type: Academic Journal
Source(s): Cell calcium [Cell Calcium] 2023 Mar; Vol. 110, pp. 102699. Date of Electronic Publication: 2023 Jan 21.
Abstract: In this brief review, we discuss the factors that modulate the quantum size and the kinetics of exocytosis. We also discuss the determinants which motivate the type of exocytosis from the so-called kiss-and-run to full fusion and along the intermediate...
Recruitment of the SNX17-Retriever recycling pathway regulates synaptic function and plasticity.
Publication Type: Academic Journal
Source(s): The Journal of cell biology [J Cell Biol] 2023 Jul 03; Vol. 222 (7). Date of Electronic Publication: 2023 May 04.
Abstract: Trafficking of cell-surface proteins from endosomes to the plasma membrane is a key mechanism to regulate synaptic function. In non-neuronal cells, proteins recycle to the plasma membrane either via the SNX27-Retromer-WASH pathway or via the recently d...
Linked Chemotype Cellular Uptake Is Facilitated by IFITMs.
Publication Type: Academic Journal
Source(s): Cancer discovery [Cancer Discov] 2023 Feb 06; Vol. 13 (2), pp. 259.
Abstract: Interferon-induced transmembrane proteins (IFITM) modulate cell permeability of diverse linked chemotypes. (©2023 American Association for Cancer Research.)
The EphA1 and EphA2 Signaling Modulates the Epithelial Permeability in Human Sinonasal Epithelial Cells and the Rhinovirus Infection Induces Epithelial Barrier Dysfunction via EphA2 Receptor Signaling.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Feb 11; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 11.
Abstract: Deficiencies in epithelial barrier integrity are involved in the pathogenesis of chronic rhinosinusitis (CRS). This study aimed to investigate the role of ephrinA1/ephA2 signaling on sinonasal epithelial permeability and rhinovirus-induced epithelial p...
Endoplasmic Reticulum-Plasma Membrane Junctions as Sites of Depolarization-Induced Ca 2+ Signaling in Excitable Cells.
Publication Type: Academic Journal
Source(s): Annual review of physiology [Annu Rev Physiol] 2023 Feb 10; Vol. 85, pp. 217-243. Date of Electronic Publication: 2022 Oct 06.
Abstract: Membrane contact sites between endoplasmic reticulum (ER) and plasma membrane (PM), or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles in organizing diverse forms of Ca 2+ signaling as triggered by membrane...
Cell surface protein aggregation triggers endocytosis to maintain plasma membrane proteostasis.
Publication Type: Academic Journal
Source(s): Nature communications [Nat Commun] 2023 Feb 28; Vol. 14 (1), pp. 947. Date of Electronic Publication: 2023 Feb 28.
Abstract: The ability of cells to manage consequences of exogenous proteotoxicity is key to cellular homeostasis. While a plethora of well-characterised machinery aids intracellular proteostasis, mechanisms involved in the response to denaturation of extracellul...
Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification.
Publication Type: Academic Journal
Source(s): The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2023 Apr 05; Vol. 43 (14), pp. 2460-2468. Date of Electronic Publication: 2023 Mar 03.
Abstract: Charged moieties in the outer hair cell (OHC) membrane motor protein, prestin, are driven by transmembrane voltage to power OHC electromotility (eM) and cochlear amplification (CA), an enhancement of mammalian hearing. Consequently, the speed of presti...