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A Click Chemistry-Based Artificial Metallo-Nuclease.
Publication Type: Academic Journal
Source(s): Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Sep 18; Vol. 62 (38), pp. e202305759. Date of Electronic Publication: 2023 Jul 04.
Abstract: Artificial metallo-nucleases (AMNs) are promising DNA damaging drug candidates. Here, we demonstrate how the 1,2,3-triazole linker produced by the Cu-catalysed azide-alkyne cycloaddition (CuAAC) reaction can be directed to build Cu-binding AMN scaffold...
Sulfur-fluoride exchange (SuFEx)-enabled lead discovery of AChE inhibitors by fragment linking strategies.
Publication Type: Academic Journal
Source(s): European journal of medicinal chemistry [Eur J Med Chem] 2023 Sep 05; Vol. 257, pp. 115502. Date of Electronic Publication: 2023 May 18.
Abstract: SuFEx click chemistry has been a method for the rapid synthesis of functional molecules with desirable properties. Here, we demonstrated a workflow that allows for in situ synthesis of sulfonamide inhibitors based on SuFEx reaction for high-throughput ...
Intelligent gold nanoparticles for malignant tumor treatment via spontaneous copper manipulation and on-demand photothermal therapy based on copper induced click chemistry.
Publication Type: Academic Journal
Source(s): Acta biomaterialia [Acta Biomater] 2023 Aug; Vol. 166, pp. 485-495. Date of Electronic Publication: 2023 Apr 29.
Abstract: The excessive copper in tumor cells is crucial for the growth and metastasis of malignant tumor. Herein, we fabricated a nanohybrid to capture, convert and utilize the overexpressed copper in tumor cells, which was expected to achieve copper dependent ...
Optimization of microwave-assisted extraction of antioxidant compounds from spring onion leaves using Box-Behnken design.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2023 Sep 10; Vol. 13 (1), pp. 14923. Date of Electronic Publication: 2023 Sep 10.
Abstract: Many studies have explored the extraction of bioactive compounds from different onion solid wastes, such as bulb, skin, and peel. However, onion leaves have received limited attention despite their potential as a valuable source of nutraceutical compou...
Medicinal Chemistry Perspectives on Recent Advances in Src Kinase Inhibitors as a Potential Target for the Development of Anticancer Agents: Biological Profile, Selectivity, Structure-Activity Relationship.
Publication Type: Academic Journal
Source(s): Chemistry & biodiversity [Chem Biodivers] 2023 Sep; Vol. 20 (9), pp. e202300515. Date of Electronic Publication: 2023 Sep 01.
Abstract: The physiological Src proto-oncogene is a protein tyrosine kinase receptor that served as the essential signaling pathway in different types of cancer. Src kinase receptor is divided into different domains: a unique domain, an SH3 domain, an SH2 domain...
A 3D paper microfluidic device for enzyme-linked assays: Application to DNA analysis.
Publication Type: Academic Journal
Source(s): Biotechnology journal [Biotechnol J] 2023 Sep; Vol. 18 (9), pp. e2300143. Date of Electronic Publication: 2023 Jun 01.
Abstract: A paper microfluidic device capable of conducting enzyme-linked assays is presented: a microfluidic enzyme-linked paper analytical device (μEL-PAD). The system exploits a wash-free sandwich coupling to form beads/analyte/enzyme complexes, which are sub...
Design of mirtazapine solid dispersion with different carriers' systems: optimization, in vitro evaluation, and bioavailability assessment.
Publication Type: Academic Journal
Source(s): Drug delivery and translational research [Drug Deliv Transl Res] 2023 Sep; Vol. 13 (9), pp. 2340-2352. Date of Electronic Publication: 2023 Mar 20.
Abstract: The solid dispersion technique is the most effective and widely used approach for increasing the solubility and release of drugs that have low water solubility. Mirtazapine (MRT) is an atypical antidepressant used to treat severe depression. MRT has a ...
Bacterial nitric oxide reductase (NorBC) models employing click chemistry.
Publication Type: Academic Journal
Source(s): Journal of inorganic biochemistry [J Inorg Biochem] 2023 Sep; Vol. 246, pp. 112280. Date of Electronic Publication: 2023 Jun 08.
Abstract: Bacterial NO Reductase (NorBC or cNOR) is a membrane-bound enzyme found in denitrifying bacteria that catalyzes the two-electron reduction of NO to N 2 O and water. The mechanism by which NorBC operates is highly debated, due to the fact that this enzy...
A critical review on the biosynthesis, properties, applications and future outlook of green MnO 2 nanoparticles.
Publication Type: Academic Journal
Source(s): Environmental research [Environ Res] 2023 Aug 15; Vol. 231 (Pt 2), pp. 116262. Date of Electronic Publication: 2023 May 27.
Abstract: MnO 2 nanoparticles have played a vital role in biomedical, catalysis, electrochemical and energy storage fields, but requiring toxic chemicals in the fabrication intercepts their applications. There is an increasing demand for biosynthesis of MnO 2 na...
Green synthesised AuNps using Ajuga Bracteosa extract and AuNps-Free supernatant exhibited equivalent antibacterial and anticancerous efficacies.
Publication Type: Academic Journal
Source(s): PloS one [PLoS One] 2023 Aug 07; Vol. 18 (8), pp. e0282485. Date of Electronic Publication: 2023 Aug 07 (Print Publication: 2023).
Abstract: The current study is designed to synthesize gold nanoparticles using Ajuga bracteosa extract, which is a highly known medicinal herb found in the northern Himalayas. The synthesized gold nanoparticles were initially characterized by UV-Vis spectrophoto...