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Optimising nasal powder drug delivery - Characterisation of the effect of excipients on drug absorption.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Feb 25; Vol. 633, pp. 122630. Date of Electronic Publication: 2023 Jan 20.
Abstract: The nasal physiology offers great potential for drug delivery but also poses specific challenges, among which the short residence time of applied drugs is one of the most striking. Formulating the drug as powder and using functional excipients are stra...
Part I: Significant reduction of lyophilization process times by using novel matrix based scaffolds.
Publication Type: Academic Journal
Source(s): European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2023 Mar; Vol. 184, pp. 248-261. Date of Electronic Publication: 2022 Dec 15.
Abstract: To improve the long-term stability of drugs with limited stability (e.g., biologicals such as monoclonal antibodies, antibody drug conjugates or peptides), some pharmaceuticals endure a lengthy and cost-intensive process called lyophilization. While th...
Elucidation of the effect of added fines on the performance of dry powder inhalation formulations.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2022 Dec 15; Vol. 629, pp. 122359. Date of Electronic Publication: 2022 Nov 01.
Abstract: Dry powder inhalers (DPIs) are regularly used to treat respiratory diseases. Adding extrinsic fine excipient particles to the blend of active pharmaceutical ingredient (API) and carrier is an established strategy to improve aerosolization efficiency du...
Trends in small molecule drug properties: A developability molecule assessment perspective.
Publication Type: Academic Journal
Source(s): Drug discovery today [Drug Discov Today] 2022 Dec; Vol. 27 (12), pp. 103366. Date of Electronic Publication: 2022 Sep 17.
Abstract: Developability molecule assessment is a key interfacial capability across the biopharmaceutical industry, screening and staging molecules discovered by medicinal chemists for successful chemistry manufacturing controls (CMC) development and launch. The...
Sulfur(VI) fluorides as tools in biomolecular and medicinal chemistry.
Publication Type: Academic Journal
Source(s): Organic & biomolecular chemistry [Org Biomol Chem] 2023 Feb 15; Vol. 21 (7), pp. 1356-1372. Date of Electronic Publication: 2023 Feb 15.
Abstract: Recent advances in the synthesis of sulfur(VI)-fluorides has enabled incredible growth in their application in biomolecular chemistry. This review aims to serve as a primer highlighting synthetic strategies toward a diversity of S(VI) fluorides and the...
Elucidation of the powder flow pattern in a twin-screw LIW-feeder for various refill regimes.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Jan 25; Vol. 631, pp. 122534. Date of Electronic Publication: 2022 Dec 20.
Abstract: The importance of residence time distribution modeling is acknowledged as a tool for enabling material tracking and control within a continuous manufacturing line in order to safeguard both product quality and production efficiency. One of the first un...
Enhanced in-situ liquid transport investigation setup for pharmaceutical tablet disintegration analysis using terahertz radiation.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Mar 25; Vol. 635, pp. 122726. Date of Electronic Publication: 2023 Feb 21.
Abstract: The disintegration process of pharmaceutical solid dosage forms commences on contact with the dissolution medium and continues with subsequent spontaneous imbibition of the medium in the tablet matrix. Identifying the location of the liquid front in si...
Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2023 Jan 06; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 06.
Abstract: Cocrystallization is currently an attractive technique for tailoring the physicochemical properties of active pharmaceutical ingredients (APIs). Flavonoids are a large class of natural products with a wide range of beneficial properties, including anti...
Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide.
Publication Type: Academic Journal
Source(s): Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Mar 16; Vol. 59 (23), pp. 3439-3442. Date of Electronic Publication: 2023 Mar 16.
Abstract: The solventless synthesis of an amide was performed in a twin-screw extruder in the presence of a coupling agent, providing a high yielding and productive method. The reaction conditions were optimized to prepare APIs, teriflunomide and moclobemide.
Mitigating Drug Stability Challenges Through Cocrystallization.
Publication Type: Academic Journal
Source(s): AAPS PharmSciTech [AAPS PharmSciTech] 2023 Feb 09; Vol. 24 (2), pp. 62. Date of Electronic Publication: 2023 Feb 09.
Abstract: Drug stability plays a significant role in the pharmaceutical industry from early-phase drug discovery to product registration as well as the entire life cycle of a product. Various formulation approaches have been employed to overcome drug stability i...