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Part I: Significant reduction of lyophilization process times by using novel matrix based scaffolds.
Publication Type: Academic Journal
Source(s): European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2023 Mar; Vol. 184, pp. 248-261. Date of Electronic Publication: 2022 Dec 15.
Abstract: To improve the long-term stability of drugs with limited stability (e.g., biologicals such as monoclonal antibodies, antibody drug conjugates or peptides), some pharmaceuticals endure a lengthy and cost-intensive process called lyophilization. While th...
Enhanced in-situ liquid transport investigation setup for pharmaceutical tablet disintegration analysis using terahertz radiation.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Mar 25; Vol. 635, pp. 122726. Date of Electronic Publication: 2023 Feb 21.
Abstract: The disintegration process of pharmaceutical solid dosage forms commences on contact with the dissolution medium and continues with subsequent spontaneous imbibition of the medium in the tablet matrix. Identifying the location of the liquid front in si...
Optimising nasal powder drug delivery - Characterisation of the effect of excipients on drug absorption.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Feb 25; Vol. 633, pp. 122630. Date of Electronic Publication: 2023 Jan 20.
Abstract: The nasal physiology offers great potential for drug delivery but also poses specific challenges, among which the short residence time of applied drugs is one of the most striking. Formulating the drug as powder and using functional excipients are stra...
Early detection and assessment of invisible cracks in compressed oral solid dosage forms.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Mar 25; Vol. 635, pp. 122786. Date of Electronic Publication: 2023 Feb 26.
Abstract: In the pharmaceutical manufacturing industry, real-time in situ quality monitoring for detecting defects at an early stage is a desirable ability, especially in high-rate production, to minimize downstream quality-related issues, financial losses, and ...
Elucidation of the powder flow pattern in a twin-screw LIW-feeder for various refill regimes.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Jan 25; Vol. 631, pp. 122534. Date of Electronic Publication: 2022 Dec 20.
Abstract: The importance of residence time distribution modeling is acknowledged as a tool for enabling material tracking and control within a continuous manufacturing line in order to safeguard both product quality and production efficiency. One of the first un...
Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2023 Jan 06; Vol. 28 (2). Date of Electronic Publication: 2023 Jan 06.
Abstract: Cocrystallization is currently an attractive technique for tailoring the physicochemical properties of active pharmaceutical ingredients (APIs). Flavonoids are a large class of natural products with a wide range of beneficial properties, including anti...
Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide.
Publication Type: Academic Journal
Source(s): Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Mar 16; Vol. 59 (23), pp. 3439-3442. Date of Electronic Publication: 2023 Mar 16.
Abstract: The solventless synthesis of an amide was performed in a twin-screw extruder in the presence of a coupling agent, providing a high yielding and productive method. The reaction conditions were optimized to prepare APIs, teriflunomide and moclobemide.
In-Process Vapor Composition Monitoring in Application to Lyophilization of Ammonium Salt Formulations.
Publication Type: Academic Journal
Source(s): Journal of pharmaceutical sciences [J Pharm Sci] 2023 Jan; Vol. 112 (1), pp. 264-271. Date of Electronic Publication: 2022 Oct 19.
Abstract: Quality control is of critical importance in manufacturing of lyophilized drug product, which is accomplished by monitoring the process parameters. The residual gas analyzer has emerged as a useful tool in determination of endpoint for primary and seco...
Continuous Manufacturing of Oil in Water (O/W) Emulgel by Extrusion Process.
Publication Type: Academic Journal
Source(s): AAPS PharmSciTech [AAPS PharmSciTech] 2023 Mar 10; Vol. 24 (3), pp. 76. Date of Electronic Publication: 2023 Mar 10.
Abstract: Pharmaceutical industries and drug regulatory agencies are inclining towards continuous manufacturing due to better control over the processing conditions and in view to improve product quality. In the present work, continuous manufacturing of O/W emul...
Evaluation of alternative methods to derive particle density from compression data.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Feb 05; Vol. 632, pp. 122582. Date of Electronic Publication: 2023 Jan 04.
Abstract: The determination of particle density is a critical part of material characterization regarding compression analyses. Helium pycnometry as the most commonly used method is criticized for different aspects. Most prominent is the susceptibility to errors...