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Newly identified variability of the antigen binding site coding sequences of the equine major histocompatibility complex class I and class II genes.
Publication Type: Academic Journal
Source(s): HLA [HLA] 2023 Oct; Vol. 102 (4), pp. 489-500. Date of Electronic Publication: 2023 Apr 27.
Abstract: The major histocompatibility complex (MHC) with its class I and II genes plays a crucial role in the immune response to pathogens by presenting oligopeptide antigens to various immune response effector cells. In order to counteract the vast variability...
Possible impact of HLA class I and class II on malignancies driven by a single germ-line BRCA1 mutation.
Publication Type: Academic Journal
Source(s): International journal of immunogenetics [Int J Immunogenet] 2023 Oct; Vol. 50 (5), pp. 243-248. Date of Electronic Publication: 2023 Jul 28.
Abstract: This study provides the first immunogenetic preliminary evidence that specific human leucocyte antigen (HLA) class I and class II alleles and haplotypes may be relevant for BRCA1 c.5263_5264insC driven oncogenesis. Observed HLA associations might h...
Stem-cell-like CD4 + T cells prey on MHC class II-negative tumors.
Publication Type: Academic Journal
Source(s): Nature immunology [Nat Immunol] 2023 Aug; Vol. 24 (8), pp. 1212-1214.
Antigen presentation in vertebrates: Structural and functional aspects.
Publication Type: Academic Journal
Source(s): Developmental and comparative immunology [Dev Comp Immunol] 2023 Jul; Vol. 144, pp. 104702. Date of Electronic Publication: 2023 Apr 26.
Abstract: Antigen presentation is a key process of the immune system and is responsible for the activation of T cells. The main characters are the major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules, and accessory proteins that act a...
SAPrIm, a semi-automated protocol for mid-throughput immunopeptidomics.
Publication Type: Academic Journal
Source(s): Frontiers in immunology [Front Immunol] 2023 Jun 02; Vol. 14, pp. 1107576. Date of Electronic Publication: 2023 Jun 02 (Print Publication: 2023).
Abstract: Human leukocyte antigen (HLA) molecules play a crucial role in directing adaptive immune responses based on the nature of their peptide ligands, collectively coined the immunopeptidome. As such, the study of HLA molecules has been of major interest in ...
Human leukocyte antigen and tumor immunotherapy (Review).
Publication Type: Academic Journal
Source(s): International journal of oncology [Int J Oncol] 2023 Jun; Vol. 62 (6). Date of Electronic Publication: 2023 Apr 28.
Abstract: Malignant tumors seriously endanger human health and life, and restrict economic development. Human leukocyte antigen (HLA) is the expression product of the human major histocompatibility complex, which, at present, is the most complex known polymorphi...
A latent class analysis of the socio-demographic factors and associations with mental and behavioral disorders among Australian children and adolescents.
Publication Type: Academic Journal
Source(s): PloS one [PLoS One] 2023 May 18; Vol. 18 (5), pp. e0285940. Date of Electronic Publication: 2023 May 18 (Print Publication: 2023).
Abstract: Background: Previous studies have shown a relationship between socio-demographic variables and the mental health of children and adolescents. However, no research has been found on a model-based cluster analysis of socio-demographic characteristics wit...
Major histocompatibility class I antigenic peptides derived from translation of pre-mRNAs generate immune tolerance.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Feb 14; Vol. 120 (7), pp. e2208509120. Date of Electronic Publication: 2023 Feb 06.
Abstract: Antigenic peptides derived from introns are presented on major histocompatibility (MHC) class I molecules, but how these peptides are produced is poorly understood. Here, we show that an MHC class I epitope (SL8) sequence inserted in the second intron ...
Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes.
Publication Type: Academic Journal
Source(s): ELife [Elife] 2023 Feb 01; Vol. 12. Date of Electronic Publication: 2023 Feb 01.
Abstract: The extreme polymorphisms of human leukocyte antigen class I (HLA class I) proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes. The canonical endoplasmic reticulum (ER) HLA class I assembly pathway enables presentation of cy...
Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins.
Publication Type: Academic Journal
Source(s): Frontiers in immunology [Front Immunol] 2023 Mar 29; Vol. 14, pp. 1107266. Date of Electronic Publication: 2023 Mar 29 (Print Publication: 2023).
Abstract: The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA reg...