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Advanced Search Results For "Class"

1 - 10 of 353,150 results for
 "Class"
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Targeting Lysine-Specific Demethylase 1 Rescues Major Histocompatibility Complex Class I Antigen Presentation and Overcomes Programmed Death-Ligand 1 Blockade Resistance in SCLC.

Publication Type:Academic Journal

Source(s):Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2022 Aug; Vol. 17 (8), pp. 1014-1031. Date of Electronic Publication: 2022 Jun 09.

Abstract:Introduction: SCLC is a highly aggressive neuroendocrine tumor that is characterized by early acquired therapeutic resistance and modest benefit from immune checkpoint blockade (ICB). Repression of the major histocompatibility complex class I (MHC-I) r...

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Intrinsic Folding Properties of the HLA-B27 Heavy Chain Revealed by Single Chain Trimer Versions of Peptide-Loaded Class I Major Histocompatibility Complex Molecules.

Publication Type:Academic Journal

Source(s):Frontiers in immunology [Front Immunol] 2022 Jul 25; Vol. 13, pp. 902135. Date of Electronic Publication: 2022 Jul 25 (Print Publication: 2022).

Abstract:Peptide-loaded Major Histocompatibility Complex (pMHC) class I molecules can be expressed in a single chain trimeric (SCT) format, composed of a specific peptide fused to the light chain beta-2 microglobulin (β2m) and MHC class I heavy chain (HC) by fl...

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Genomic landscape of lymphatic malformations: a case series and response to the PI3Kα inhibitor alpelisib in an N -of-1 clinical trial.

Publication Type:Academic Journal

Source(s):ELife [Elife] 2022 Jul 05; Vol. 11. Date of Electronic Publication: 2022 Jul 05.

Abstract:Background: Lymphatic malformations (LMs) often pose treatment challenges due to a large size or a critical location that could lead to disfigurement, and there are no standardized treatment approaches for either refractory or unresectable cases.Method...

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Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome.

Publication Type:Academic Journal

Source(s):Frontiers in immunology [Front Immunol] 2022 May 16; Vol. 13, pp. 878271. Date of Electronic Publication: 2022 May 16 (Print Publication: 2022).

Abstract:In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented pe...

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3pHLA-score improves structure-based peptide-HLA binding affinity prediction.

Publication Type:Academic Journal

Source(s):Scientific reports [Sci Rep] 2022 Jun 24; Vol. 12 (1), pp. 10749. Date of Electronic Publication: 2022 Jun 24.

Abstract:Binding of peptides to Human Leukocyte Antigen (HLA) receptors is a prerequisite for triggering immune response. Estimating peptide-HLA (pHLA) binding is crucial for peptide vaccine target identification and epitope discovery pipelines. Computational m...

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Substrate-specific presentation of MHC class I-restricted antigens via autophagy pathway.

Publication Type:Academic Journal

Source(s):Cellular immunology [Cell Immunol] 2022 Apr; Vol. 374, pp. 104484. Date of Electronic Publication: 2022 Feb 17.

Abstract:The accumulation of protein aggregates is toxic and linked to different diseases such as neurodegenerative disorders, but the role of the immune system to target and destroy aggregate-carrying cells is still relatively unknown. Here we show a substrate...

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Unsupervised Mining of HLA-I Peptidomes Reveals New Binding Motifs and Potential False Positives in the Community Database.

Publication Type:Academic Journal

Source(s):Frontiers in immunology [Front Immunol] 2022 Mar 21; Vol. 13, pp. 847756. Date of Electronic Publication: 2022 Mar 21 (Print Publication: 2022).

Abstract:Modern vaccine designs and studies of human leukocyte antigen (HLA)-mediated immune responses rely heavily on the knowledge of HLA allele-specific binding motifs and computational prediction of HLA-peptide binding affinity. Breakthroughs in HLA peptido...

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Socioeconomic Classes among Oldest-Old Women in South Korea: A Latent Class Analysis.

Publication Type:Academic Journal

Source(s):International journal of environmental research and public health [Int J Environ Res Public Health] 2021 Dec 14; Vol. 18 (24). Date of Electronic Publication: 2021 Dec 14.

Abstract:Oldest-old women are known to live at the intersection of multiple socioeconomic disadvantages in South Korean society. This study classified oldest-old Korean women into several socioeconomically homogeneous classes based on various socioeconomic stat...

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Using Latent Class Analysis to Explore Complex Associations Between Socioeconomic Status and Adolescent Health and Well-Being.

Publication Type:Academic Journal

Source(s):The Journal of adolescent health : official publication of the Society for Adolescent Medicine [J Adolesc Health] 2021 Nov; Vol. 69 (5), pp. 774-781. Date of Electronic Publication: 2021 Jul 15.

Abstract:Purpose: Research demonstrates a strong socioeconomic gradient in health and well-being. However, many studies rely on unidimensional measures of socioeconomic status (SES) (e.g. educational qualifications, household income), and there is often a more ...

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Know thy immune self and non-self: Proteomics informs on the expanse of self and non-self, and how and where they arise.

Publication Type:Academic Journal

Source(s):Proteomics [Proteomics] 2021 Dec; Vol. 21 (23-24), pp. e2000143. Date of Electronic Publication: 2021 Aug 09.

Abstract:T cells play an important role in the adaptive immune response to a variety of infections and cancers. Initiation of a T cell mediated immune response requires antigen recognition in a process termed MHC (major histocompatibility complex) restri ction....

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