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P16 INK4a Regulates ROS-Related Autophagy and CDK4/6-Mediated Proliferation: A New Target of Myocardial Regeneration Therapy.
Publication Type: Academic Journal
Source(s): Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2023 Feb 18; Vol. 2023, pp. 1696190. Date of Electronic Publication: 2023 Feb 18 (Print Publication: 2023).
Abstract: Neonatal mice achieve complete cardiac repair through endogenous myocardial regeneration after apical resection (AR), but this capacity is rapidly lost 7 days after birth. As an upstream inhibitor of cyclin-dependent kinase 4/6- (CDK4/6-) mediated cell...
Senolytic effect of high intensity interval exercise on human skeletal muscle.
Publication Type: Academic Journal
Source(s): Aging [Aging (Albany NY)] 2023 Feb 08; Vol. 15 (3), pp. 765-776. Date of Electronic Publication: 2023 Feb 08.
Abstract: p16 INK4a expression is a robust biomarker of senescence for stem cells in human tissues. Here we examined the effect of exercise intensity on in vivo senescence in skeletal muscle, using a randomized counter-balanced crossover design. Biopsied vastus ...
P16 and P21 are involved in the pathogenesis of endometrial thinning: A cross-sectional study.
Publication Type: Academic Journal
Source(s): Medicine [Medicine (Baltimore)] 2022 Oct 07; Vol. 101 (40), pp. e30987.
Abstract: P16 plays a role in the negative regulation of cell proliferation, regulating cell apoptosis to control the growth of tumor cells. P21 is a nuclear protein that suppresses DNA synthesis and inhibits cell division. This study aimed to examine the expres...
Transcriptional regulation of CDKN2A/p16 by sirtuin 7 in senescence.
Publication Type: Academic Journal
Source(s): Molecular medicine reports [Mol Med Rep] 2022 Nov; Vol. 26 (5). Date of Electronic Publication: 2022 Sep 28.
Abstract: Cell senescence is a state of limited cell proliferation during a stress response or as part of a programmed process. When a senescent cell stops dividing, maintaining metabolic activity contributes to cellular homeostasis maintenance. In this process,...
Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity.
Publication Type: Academic Journal
Source(s): Aging cell [Aging Cell] 2022 May; Vol. 21 (5), pp. e13602. Date of Electronic Publication: 2022 Apr 01.
Abstract: Cellular senescence, which is a major cause of tissue dysfunction with aging and multiple other conditions, is known to be triggered by p16 Ink4a or p21 Cip1 , but the relative contributions of each pathway toward inducing senescence are unclear. Here,...
Presentation and management of diverse cutaneous reactions after cyclin-dependent kinase 4/6 inhibitor use.
Publication Type: Academic Journal
Source(s): Journal of the American Academy of Dermatology [J Am Acad Dermatol] 2022 Jun; Vol. 86 (6), pp. 1346-1348. Date of Electronic Publication: 2021 May 05.
Abstract: Competing Interests: Conflicts of interest None disclosed.
The impact of senescence on muscle wasting in chronic kidney disease.
Publication Type: Academic Journal
Source(s): Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2023 Feb; Vol. 14 (1), pp. 126-141. Date of Electronic Publication: 2022 Nov 09.
Abstract: Background: Muscle wasting is a common complication of chronic kidney disease (CKD) that is associated with higher mortality. Although the mechanisms of myofibre loss in CKD has been widely studied, the contribution of muscle precursor cell (MPC) senes...
Cellular senescence marker p16 INK4a and NFKB1 gene polymorphisms in lower gastro-intestinal acute graft versus host disease.
Publication Type: Academic Journal
Source(s): Transplant immunology [Transpl Immunol] 2023 Feb; Vol. 76, pp. 101768. Date of Electronic Publication: 2022 Dec 02.
Abstract: Background: Lower gastrointestinal (GI) graft versus host disease (GVHD) represents a severe complication in allogeneic hematopoietic stem cell transplant (HSCT) recipients with high rates of transplant-related mortality. Deregulated innate immunity re...
Immortalized murine tenocyte cells: a novel and innovative tool for tendon research.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2023 Jan 28; Vol. 13 (1), pp. 1566. Date of Electronic Publication: 2023 Jan 28.
Abstract: Primary tenocytes rapidly undergo senescence and a phenotypic drift upon in vitro monolayer culture, which limits tendon research. The Ink4a/Arf locus encodes the proteins p16 Ink4a/Arf and p14 ARF (p19 ARF in mice) that regulate cell cycle progression...
Higher Oxidative Stress in Endometriotic Lesions Upregulates Senescence-Associated p16 ink4a and β-Galactosidase in Stromal Cells.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jan 04; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 04.
Abstract: Endometriosis affects a significant proportion of women worldwide; however, no definitive cure for this disease has been discovered to date. Oxidative stress promotes endometriotic lesion maintenance in the peritoneal cavity in women. Furthermore, ther...