Advanced Search Results For "Cyclin-Dependent Kinase Inhibitor p16 genetics"
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P16 INK4a Regulates ROS-Related Autophagy and CDK4/6-Mediated Proliferation: A New Target of Myocardial Regeneration Therapy.
Publication Type: Academic Journal
Source(s): Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2023 Feb 18; Vol. 2023, pp. 1696190. Date of Electronic Publication: 2023 Feb 18 (Print Publication: 2023).
Abstract: Neonatal mice achieve complete cardiac repair through endogenous myocardial regeneration after apical resection (AR), but this capacity is rapidly lost 7 days after birth. As an upstream inhibitor of cyclin-dependent kinase 4/6- (CDK4/6-) mediated cell...
Transcriptional regulation of CDKN2A/p16 by sirtuin 7 in senescence.
Publication Type: Academic Journal
Source(s): Molecular medicine reports [Mol Med Rep] 2022 Nov; Vol. 26 (5). Date of Electronic Publication: 2022 Sep 28.
Abstract: Cell senescence is a state of limited cell proliferation during a stress response or as part of a programmed process. When a senescent cell stops dividing, maintaining metabolic activity contributes to cellular homeostasis maintenance. In this process,...
Dissecting the influence of cellular senescence on cell mechanics and extracellular matrix formation in vitro.
Publication Type: Academic Journal
Source(s): Aging cell [Aging Cell] 2023 Mar; Vol. 22 (3), pp. e13744. Date of Electronic Publication: 2022 Dec 13.
Abstract: Tissue formation and healing both require cell proliferation and migration, but also extracellular matrix production and tensioning. In addition to restricting proliferation of damaged cells, increasing evidence suggests that cellular senescence also h...
Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity.
Publication Type: Academic Journal
Source(s): Aging cell [Aging Cell] 2022 May; Vol. 21 (5), pp. e13602. Date of Electronic Publication: 2022 Apr 01.
Abstract: Cellular senescence, which is a major cause of tissue dysfunction with aging and multiple other conditions, is known to be triggered by p16 Ink4a or p21 Cip1 , but the relative contributions of each pathway toward inducing senescence are unclear. Here,...
Cellular senescence marker p16 INK4a and NFKB1 gene polymorphisms in lower gastro-intestinal acute graft versus host disease.
Publication Type: Academic Journal
Source(s): Transplant immunology [Transpl Immunol] 2023 Feb; Vol. 76, pp. 101768. Date of Electronic Publication: 2022 Dec 02.
Abstract: Background: Lower gastrointestinal (GI) graft versus host disease (GVHD) represents a severe complication in allogeneic hematopoietic stem cell transplant (HSCT) recipients with high rates of transplant-related mortality. Deregulated innate immunity re...
Methyltransferase Inhibition Enables Tgf β Driven Induction of CDKN2A and B in Cancer Cells.
Publication Type: Academic Journal
Source(s): Molecular and cellular biology [Mol Cell Biol] 2023; Vol. 43 (3), pp. 115-129.
Abstract: CDKN2A/B deletion or silencing is common across human cancer, reinforcing the general importance of bypassing its tumor suppression in cancer formation or progression. In rhabdomyosarcoma (RMS) and neuroblastoma, two common childhood cancers, the three...
The impact of senescence on muscle wasting in chronic kidney disease.
Publication Type: Academic Journal
Source(s): Journal of cachexia, sarcopenia and muscle [J Cachexia Sarcopenia Muscle] 2023 Feb; Vol. 14 (1), pp. 126-141. Date of Electronic Publication: 2022 Nov 09.
Abstract: Background: Muscle wasting is a common complication of chronic kidney disease (CKD) that is associated with higher mortality. Although the mechanisms of myofibre loss in CKD has been widely studied, the contribution of muscle precursor cell (MPC) senes...
Correlation of MTAP immunohistochemical deficiency with CDKN2A homozygous deletion and clinicopathological features in pleomorphic xanthoastrocytoma.
Publication Type: Academic Journal
Source(s): Brain tumor pathology [Brain Tumor Pathol] 2023 Jan; Vol. 40 (1), pp. 15-25. Date of Electronic Publication: 2022 Dec 22.
Abstract: Pleomorphic xanthoastrocytoma (PXA) is a rare tumor ranging from World Health Organization (WHO) grades 2-3 and can potentially recur and metastasize throughout the central nervous system (CNS). Cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) deletio...
The "m6A writer" METTL3 and the "m6A reader" IGF2BP2 regulate cutaneous T-cell lymphomas progression via CDKN2A.
Publication Type: Academic Journal
Source(s): Hematological oncology [Hematol Oncol] 2022 Oct; Vol. 40 (4), pp. 567-576. Date of Electronic Publication: 2022 Apr 29.
Abstract: It has been established that Cutaneous T-Cell lymphomas (CTCL) are caused by the monoclonal proliferation of T lymphocytes in the skin. This heterogeneous group of diseases represents a significant source of distress to patients since the diagnosis and...
Screening of potential novel candidate genes in schwannomatosis patients.
Publication Type: Academic Journal
Source(s): Human mutation [Hum Mutat] 2022 Oct; Vol. 43 (10), pp. 1368-1376. Date of Electronic Publication: 2022 Jun 27.
Abstract: Schwannomatosis comprises a group of hereditary tumor predisposition syndromes characterized by, usually benign, multiple nerve sheath tumors, which frequently cause severe pain that does not typically respond to drug treatments. The most common schwan...