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Advanced Search Results For "DEAD"

1 - 10 of 103,756 results for
 "DEAD"
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RIG-I-like Receptor Regulation of Immune Cell Function and Therapeutic Implications.

Publication Type:Academic Journal

Source(s):Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Sep 01; Vol. 209 (5), pp. 845-854.

Abstract:Retinoic acid-inducible gene I-like receptors (RLRs) are cytosolic RNA sensors critical for initiation of antiviral immunity. Activation of RLRs following RNA recognition leads to production of antiviral genes and IFNs for induction of broad antiviral ...

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The intrinsically disordered CARDs-Helicase linker in RIG-I is a molecular gate for RNA proofreading.

Publication Type:Academic Journal

Source(s):The EMBO journal [EMBO J] 2022 May 16; Vol. 41 (10), pp. e109782. Date of Electronic Publication: 2022 Apr 19.

Abstract:The innate immune receptor RIG-I provides a first line of defense against viral infections. Viral RNAs are recognized by RIG-I's C-terminal domain (CTD), but the RNA must engage the helicase domain to release the signaling CARD (Caspase Activation and ...

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Genetic Variation in DEAD-Box Helicase 20 as a Putative Marker of Recurrence in Propensity-Matched Colon Cancer Patients.

Publication Type:Academic Journal

Source(s):Genes [Genes (Basel)] 2022 Aug 07; Vol. 13 (8). Date of Electronic Publication: 2022 Aug 07.

Abstract:Variants of the DEAD-Box Helicase 20 (DDX20), one of the microRNAs (miRNAs) machinery genes, can modulate miRNA/target gene expressions and, hence, influence cancer susceptibility and prognosis. Here, we aimed to unravel the association of DDX20 rs1974...

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DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection.

Publication Type:Academic Journal

Source(s):Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2021 Aug 13; Vol. 11, pp. 725392. Date of Electronic Publication: 2021 Aug 13 (Print Publication: 2021).

Abstract:Previous studies have shown that DEAD (Glu-Asp-Ala-Glu)-box RNA helicases play important roles in viral infection, either as cytosolic sensors of pathogenic molecules or as essential host factors against viral infection. In the current study, we found ...

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The X-Linked Helicase DDX3X Is Required for Lymphoid Differentiation and MYC-Driven Lymphomagenesis.

Publication Type:Academic Journal

Source(s):Cancer research [Cancer Res] 2022 Sep 02; Vol. 82 (17), pp. 3172-3186.

Abstract:The X-linked gene DDX3X encodes an RNA helicase that is mutated at high frequencies in several types of human B-cell lymphoma. Females have two active DDX3X alleles and males carry a DDX3Y homolog on the Y chromosome. We show here that pan-hematopoieti...

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RNA Helicase DDX24 Stabilizes LAMB1 to Promote Hepatocellular Carcinoma Progression.

Publication Type:Academic Journal

Source(s):Cancer research [Cancer Res] 2022 Sep 02; Vol. 82 (17), pp. 3074-3087.

Abstract:Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies. Elucidating the underlying mechanisms of this disease could provide new therapeutic strategies for treating HCC. Here, we identified a novel role of DEAD-box helicase 24 (DDX24)...

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Dead space washout by intentional leakage flow during conventional ventilation of premature infants-an experimental study.

Publication Type:Academic Journal

Source(s):Pediatric pulmonology [Pediatr Pulmonol] 2022 Sep; Vol. 57 (9), pp. 1998-2002. Date of Electronic Publication: 2022 Jun 20.

Abstract:Objective: Invasive mechanical ventilation poses a strong risk factor for the development of chronic lung disease in preterm infants. A reduction of the dead space as part of the total breathing volume would reduce the ventilation effort and thereby lo...

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The RNA helicase DDX5 cooperates with EHMT2 to sustain alveolar rhabdomyosarcoma growth.

Publication Type:Academic Journal

Source(s):Cell reports [Cell Rep] 2022 Aug 30; Vol. 40 (9), pp. 111267.

Abstract:Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood characterized by the inability to exit the proliferative myoblast-like stage. The alveolar fusion positive subtype (FP-RMS) is the most aggressive and is mainly caused by the ex...

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DDX3X alleviates doxorubicin-induced cardiotoxicity by regulating Wnt/β-catenin signaling pathway in an in vitro model.

Publication Type:Academic Journal

Source(s):Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2022 Aug; Vol. 36 (8), pp. e23077. Date of Electronic Publication: 2022 Apr 25.

Abstract:The life-threatening adverse effects of doxorubicin (Dox) caused by its cardiotoxic properties limit its clinical application. DDX3X has been shown to participate in a variety of physiological processes, and it acts as a regulator of Wnt/β-catenin sign...

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DEAD box 1 (DDX1) protein binds to and protects cytoplasmic stress response mRNAs in cells exposed to oxidative stress.

Publication Type:Academic Journal

Source(s):The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102180. Date of Electronic Publication: 2022 Jun 23.

Abstract:The integrated stress response is a network of highly orchestrated pathways activated when cells are exposed to environmental stressors. While global repression of translation is a well-recognized hallmark of the integrated stress response, less is kno...

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