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Lactobacillaceae improve cognitive dysfunction via regulating gut microbiota and suppressing Aβ deposits and neuroinflammation in APP/PS1 mice.
Publication Type: Academic Journal
Source(s): Archives of microbiology [Arch Microbiol] 2023 Mar 16; Vol. 205 (4), pp. 118. Date of Electronic Publication: 2023 Mar 16.
Abstract: Alzheimer's disease (AD), the most prevalent neurodegenerative disease, has a significant relationship with alteration of the gut microbiota (GM), and the GM-gut-brain axis has been explored to find novel therapeutic approaches for AD. The present stud...
Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington's disease.
Publication Type: Academic Journal
Source(s): Neurobiology of disease [Neurobiol Dis] 2023 Feb; Vol. 177, pp. 106004. Date of Electronic Publication: 2023 Jan 17.
Abstract: Huntington's disease (HD) is an autosomal dominant neurodegenerative disease, characterized by motor dysfunction and abnormal energy metabolism. Equilibrative nucleoside transporter 1 (ENT1) and ENT2 are the major nucleoside transporters in cellular pl...
Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer's disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathway.
Publication Type: Academic Journal
Source(s): Journal of neuroinflammation [J Neuroinflammation] 2023 Jan 30; Vol. 20 (1), pp. 19. Date of Electronic Publication: 2023 Jan 30.
Abstract: Background: Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by progressive cognitive dysfunctions and behavioral impairments. Patchouli alcohol (PA), isolated from Pogostemonis Herba, exhibits multiple pharmacological prop...
Trends in gastrointestinal disease hospitalizations and outcomes during the first year of the coronavirus pandemic.
Publication Type: Academic Journal
Source(s): World journal of gastroenterology [World J Gastroenterol] 2023 Jan 28; Vol. 29 (4), pp. 744-757.
Abstract: Background: The impact of the coronavirus on hospitalizations for gastrointestinal (GI) disease, particularly at a population level is understudied.Aim: To investigate trends in hospitalizations, inpatient endoscopy resource utilization, and outcomes d...
Dopamine D2 receptor agonist Bromocriptine ameliorates Aβ 1-42 -induced memory deficits and neuroinflammation in mice.
Publication Type: Academic Journal
Source(s): European journal of pharmacology [Eur J Pharmacol] 2023 Jan 05; Vol. 938, pp. 175443. Date of Electronic Publication: 2022 Dec 02.
Abstract: Alzheimer's Disease (AD) is the most common neurodegenerative disease, which lacks disease-modifying therapeutics so far. Studies have shown that the dysfunction of the dopaminergic system is related to a variety of pathophysiology of AD, and the expre...
Blood Markers of Inflammation, Neurodegeneration, and Cardiovascular Risk in Early Parkinson's Disease.
Publication Type: Academic Journal
Source(s): Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2023 Jan; Vol. 38 (1), pp. 68-81. Date of Electronic Publication: 2022 Oct 20.
Abstract: Background: Recent studies point toward a significant impact of cardiovascular processes and inflammation on Parkinson's disease (PD) progression.Objective: The aim of this study was to assess established markers of neuronal function, inflammation, and...
Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson's disease.
Publication Type: Academic Journal
Source(s): Journal of neuroinflammation [J Neuroinflammation] 2023 Mar 21; Vol. 20 (1), pp. 79. Date of Electronic Publication: 2023 Mar 21.
Abstract: Neuroinflammation has been suggested as a pathogenetic mechanism contributing to Parkinson's disease (PD). However, anti-inflammatory treatment strategies have not yet been established as a therapeutic option for PD patients. We have used a human α-syn...
New Onset or Deterioration of Thyroid Eye Disease After mRNA SARS-CoV-2 Vaccines: Report of 2 Cases and Literature Review.
Publication Type: Academic Journal
Source(s): The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2023 Mar 10; Vol. 108 (4), pp. 979-985.
Abstract: Context: Occurrence of Graves' disease (GD) has been reported following SARS-CoV-2 vaccine administration, but little is known about thyroid eye disease (TED) after SARS-CoV-2 vaccination.Objective: We describe 2 cases of TED activation following mRNA ...
The global burden of metabolic disease: Data from 2000 to 2019.
Publication Type: Academic Journal
Source(s): Cell metabolism [Cell Metab] 2023 Mar 07; Vol. 35 (3), pp. 414-428.e3.
Abstract: Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for metabolic diseases (type 2 diabetes mellitus [T2DM], hypertension, and non-al...
Pathogenic role of Th17 cells in autoimmune thyroid disease and their underlying mechanisms.
Publication Type: Academic Journal
Source(s): Best practice & research. Clinical endocrinology & metabolism [Best Pract Res Clin Endocrinol Metab] 2023 Mar; Vol. 37 (2), pp. 101743. Date of Electronic Publication: 2023 Feb 08.
Abstract: Autoimmune thyroid disease, encompassing Graves' disease and Hashimoto's thyroiditis, has a very complex etiology. Pathogenesis of the disease involves both genetic susceptibility and environmental triggers. Traditionally, imbalance of T helper cell 1 ...