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Advanced Search Results For "DNA"

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 "DNA"
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A homogeneous fluorescence assay for rapid and sensitive quantification of the global level of abasic sites in genomic DNA.

Publication Type: Academic Journal

Source(s): DNA repair [DNA Repair (Amst)] 2023 Feb; Vol. 122, pp. 103451. Date of Electronic Publication: 2023 Jan 13.

Authors:

Abstract: The apurinic/apyrimidinic (AP) sites are frequent DNA lesions in genomic DNA (gDNA). Here we report a facile approach for rapid quantification of the AP sites in gDNA with high selectivity and sensitivity. With the assistance of T4 pyrimidine dimer gly...

Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.

Publication Type: Academic Journal

Source(s): Molecular cell [Mol Cell] 2023 Jan 19; Vol. 83 (2), pp. 167-185.e9. Date of Electronic Publication: 2022 Dec 27.

Abstract: The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at break sites. How MRN can act both as nuclease and scaffold protein is not well understood. Th...

The FANCJ helicase unfolds DNA-protein crosslinks to promote their repair.

Publication Type: Academic Journal

Source(s): Molecular cell [Mol Cell] 2023 Jan 05; Vol. 83 (1), pp. 43-56.e10.

Abstract: Endogenous and exogenous agents generate DNA-protein crosslinks (DPCs), whose replication-dependent degradation by the SPRTN protease suppresses aging and liver cancer. SPRTN is activated after the replicative CMG helicase bypasses a DPC and polymerase...

Characterization of the Escherichia coli XPD/Rad3 iron-sulfur helicase YoaA in complex with the DNA polymerase III clamp loader subunit chi (χ).

Publication Type: Academic Journal

Source(s): The Journal of biological chemistry [J Biol Chem] 2023 Jan; Vol. 299 (1), pp. 102786. Date of Electronic Publication: 2022 Dec 09.

Abstract: Escherichia coli YoaA aids in the resolution of DNA damage that halts DNA synthesis in vivo in conjunction with χ, an accessory subunit of DNA polymerase III. YoaA and χ form a discrete complex separate from the DNA polymerase III holoenzyme, but littl...

Variable DNA topology is an epigenetic generator of physiological heterogeneity in bacterial populations.

Publication Type: Academic Journal

Source(s): Molecular microbiology [Mol Microbiol] 2023 Jan; Vol. 119 (1), pp. 19-28. Date of Electronic Publication: 2022 Dec 30.

Authors:

Abstract: Transcription is a noisy and stochastic process that produces sibling-to-sibling variations in physiology across a population of genetically identical cells. This pattern of diversity reflects, in part, the burst-like nature of transcription. Transcrip...

S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair.

Publication Type: Academic Journal

Source(s): ELife [Elife] 2022 Oct 03; Vol. 11. Date of Electronic Publication: 2022 Oct 03.

Abstract: The mTORC1 substrate, S6 Kinase 1 (S6K1), is involved in the regulation of cell growth, ribosome biogenesis, glucose homeostasis, and adipogenesis. Accumulating evidence has suggested a role for mTORC1 signaling in the DNA damage response. This is most...

Pol32, an accessory subunit of DNA polymerase delta, plays an essential role in genome stability and pathogenesis of Candida albicans .

Publication Type: Academic Journal

Source(s): Gut microbes [Gut Microbes] 2023 Jan-Dec; Vol. 15 (1), pp. 2163840.

Abstract: Candida albicans is a pathobiont that inflicts serious bloodstream fungal infections in individuals with compromised immunity and gut dysbiosis. Genomic diversity in the form of copy number alteration, ploidy variation, and loss of heterozygosity as an...

Kinetics of DNA strand transfer between polymerase and proofreading exonuclease active sites regulates error correction during high-fidelity replication.

Publication Type: Academic Journal

Source(s): The Journal of biological chemistry [J Biol Chem] 2023 Jan; Vol. 299 (1), pp. 102744. Date of Electronic Publication: 2022 Nov 24.

Abstract: We show that T7 DNA polymerase (pol) and exonuclease (exo) domains contribute to selective error correction during DNA replication by regulating bidirectional strand transfer between the two active sites. To explore the kinetic basis for selective remo...

Defective DNA polymerase beta invoke a cytosolic DNA mediated inflammatory response.

Publication Type: Academic Journal

Source(s): Frontiers in immunology [Front Immunol] 2022 Dec 23; Vol. 13, pp. 1039009. Date of Electronic Publication: 2022 Dec 23 (Print Publication: 2022).

Abstract: Base excision repair (BER) has evolved to maintain the genomic integrity of DNA following endogenous and exogenous agent induced DNA base damage. In contrast, aberrant BER induces genomic instability, promotes malignant transformation and can even trig...

The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining.

Publication Type: Academic Journal

Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Dec 06; Vol. 119 (49), pp. e2208904119. Date of Electronic Publication: 2022 Nov 29.

Abstract: The protooncoprotein N-Myc, which is overexpressed in approximately 25% of neuroblastomas as the consequence of MYCN gene amplification, has long been postulated to regulate DNA double-strand break (DSB) repair in neuroblastoma cells, but experimental ...

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