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Gold Nanoparticles Functionalized with Au-Se-Bonded Peptides Used as Gatekeepers for the Off-Target Release of Resveratrol in the Treatment of Triple-Negative Breast Cancer.
Publication Type: Academic Journal
Source(s): ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2023 Jan 18; Vol. 15 (2), pp. 2529-2537. Date of Electronic Publication: 2023 Jan 03.
Abstract: Resveratrol has been garnering considerable attention as a promising chemopreventive and chemotherapeutic drug against metastatic tumors such as triple-negative breast cancer (TNBC). However, the potential in vivo application of resveratrol has been hi...
Achievements and Bottlenecks of PEGylation in Nano-delivery Systems.
Publication Type: Academic Journal
Source(s): Current medicinal chemistry [Curr Med Chem] 2023; Vol. 30 (12), pp. 1386-1405.
Abstract: Poly(ethylene glycol) (PEG) has been widely applied in the biomedical field as a gold standard. The conjugation of PEG to proteins, peptides, oligonucleotides (DNA, small interfering RNA (siRNA), microRNA (miRNA)) and nanoparticles, also known as PEGyl...
Enhanced oral bioavailability from food protein nanoparticles: A mini review.
Publication Type: Academic Journal
Source(s): Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2023 Feb; Vol. 354, pp. 146-154. Date of Electronic Publication: 2023 Jan 06.
Abstract: The oral route is the most desirable drug administration path. The oral bioavailability is always compromised from the poor physicochemical and/or biopharmaceutical properties of the active pharmaceutical ingredients. Food protein nanoparticles show pr...
Implementation of Quality by Design in the Formulation and Development of Nanocarrier-Based Drug Delivery Systems.
Publication Type: Academic Journal
Source(s): Critical reviews in therapeutic drug carrier systems [Crit Rev Ther Drug Carrier Syst] 2023; Vol. 40 (3), pp. 1-46.
Abstract: Quality by design (QbD) has recently fascinated researchers for utilizing it in various arenas of pharma trends. By overcoming the conventional process, QbD prevents the risk of errors caused by the 'guess and by god approach'. This framework fosters p...
Formulation and Statistical Evaluation of Tablets Containing Pitavastatin- Self Nano Emulsifying Drug Delivery Systems.
Publication Type: Academic Journal
Source(s): Current drug delivery [Curr Drug Deliv] 2023; Vol. 20 (4), pp. 414-432.
Abstract: Purpose: To formulate and characterize tablets containing Pitavastatin that have been loaded with a self-nano emulsifying drug delivery system (SNEDDS).Methods: Pitavastatin SNEDDS were prepared with a variety of oils, surfactants, co-surfactants, and ...
Rolling Circle Amplification-Based DNA Nano-Assembly for Targeted Drug Delivery and Gene Therapy.
Publication Type: Academic Journal
Source(s): Biomacromolecules [Biomacromolecules] 2023 Jan 09; Vol. 24 (1), pp. 439-448. Date of Electronic Publication: 2022 Dec 06.
Abstract: Combining the killing ability of chemotherapy drugs on tumor cells with the inhibiting ability of genetic drugs on tumor cell growth, a dual drug delivery system loaded with therapy drugs and siRNA has gradually received more and more research and exte...
Nano drug delivery systems for antisense oligonucleotides (ASO) therapeutics.
Publication Type: Academic Journal
Source(s): Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2022 Dec; Vol. 352, pp. 861-878. Date of Electronic Publication: 2022 Nov 14.
Abstract: Cancer, infectious diseases, and metabolic and hereditary genetic disorders are a global health burden affecting millions of people, with contemporary treatments offering limited relief. Antisense technology treats diseases by targeting their causal ag...
Effect of Lipophilic Chains on the Antitumor Effect of a Dendritic Nano Drug Delivery System.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2022 Dec 21; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 21.
Abstract: Oligoethylene glycol dendron (G2) has been used in drug delivery due to its unique dendritic structure and excellent properties. In order to investigate the effects of lipophilic chains on drug delivery, the amphiphilic hybrid compound G2-C18 is synthe...
Nano-enabled plant-based colloidal delivery systems for bioactive agents in foods: Design, formulation, and application.
Publication Type: Academic Journal
Source(s): Advances in colloid and interface science [Adv Colloid Interface Sci] 2022 Jul; Vol. 305, pp. 102709. Date of Electronic Publication: 2022 May 26.
Abstract: Consumers are becoming increasingly aware of the impact of their dietary choices on the environment, animal welfare, and health, which is causing many of them to adopt more plant-based diets. For this reason, many sectors of the food industry are refor...
Lymphatic targeting for therapeutic application using nanoparticulate systems.
Publication Type: Academic Journal
Source(s): Journal of drug targeting [J Drug Target] 2022 Dec; Vol. 30 (10), pp. 1017-1033. Date of Electronic Publication: 2022 Jul 04.
Abstract: The lymphatic system has grasped attention of researchers to a greater extent. The conventional methods of lymphatic delivery are now being modified to include nanotechnology to enhance the targeting of the drug at the specific pathological site. Scien...