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Advanced Search Results For "EPITHELIAL cells"

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 "EPITHELIAL cells"
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Effect of Baricitinib on the epithelial-mesenchymal transition of alveolar epithelial cells induced by IL-6.

Publication Type: Academic Journal

Source(s): International immunopharmacology [Int Immunopharmacol] 2022 Sep; Vol. 110, pp. 109044. Date of Electronic Publication: 2022 Jul 15.

Authors:

Abstract: Objective: Interstitial lung disease (ILD) is one of the common complications of Connective tissue disease (CTD). Epithelial-mesenchymal transition (EMT) is one of the main pathological mechanisms of ILD. IL-6 may induce ILD through the JAK/STAT pathwa...

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IL-17A promotes lung fibrosis through impairing mitochondrial homeostasis in type II alveolar epithelial cells.

Publication Type: Academic Journal

Source(s): Journal of cellular and molecular medicine [J Cell Mol Med] 2022 Nov; Vol. 26 (22), pp. 5728-5741. Date of Electronic Publication: 2022 Oct 29.

Authors:

Abstract: The dysfunction of type II alveolar epithelial cells (AECIIs), mainly manifested by apoptosis, has emerged as a major component of idiopathic pulmonary fibrosis (IPF) pathophysiology. A pivotal mechanism leading to AECIIs apoptosis is mitochondrial dys...

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Wnt5a Promotes AT1 and Represses AT2 Lineage-Specific Gene Expression in a Cell-Context-Dependent Manner.

Publication Type: Academic Journal

Source(s): Stem cells (Dayton, Ohio) [Stem Cells] 2022 Jul 27; Vol. 40 (7), pp. 691-703.

Abstract: Lung maturation is not limited to proper structural development but also includes differentiation and functionality of various highly specialized alveolar cell types. Alveolar type 1 (AT1s) cells occupy nearly 95% of the alveolar surface and are critic...

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Alveolar Basal Cells Differentiate towards Secretory Epithelial- and Aberrant Basaloid-like Cells In Vitro.

Publication Type: Academic Journal

Source(s): Cells [Cells] 2022 Jun 02; Vol. 11 (11). Date of Electronic Publication: 2022 Jun 02.

Abstract: In idiopathic pulmonary fibrosis (IPF), keratin (KRT)17+/KRT5+ basal and KRT17+/KRT5- aberrant basaloid cells are atypically present within the alveolar space. We previously described the fibrosis-enriched outgrowth of alveolar basal cells from periphe...

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[Establishment of a three-dimensional organoid culture system for mouse type 2 alveolar epithelial cells].

Publication Type: Academic Journal

Source(s): Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2022 Aug 25; Vol. 74 (4), pp. 585-595.

Authors:

Abstract: The purpose of this study was to establish a three-dimensional (3D) organoid culture system for type 2 alveolar epithelial (AT2) cells in mice. AT2 cells were isolated from ICR mouse lung and purified by enzymatic digestion and MicroBeads sorting. The ...

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CD90 Marks a Mesenchymal Program in Human Thymic Epithelial Cells In Vitro and In Vivo .

Publication Type: Academic Journal

Source(s): Frontiers in immunology [Front Immunol] 2022 Mar 16; Vol. 13, pp. 846281. Date of Electronic Publication: 2022 Mar 16 (Print Publication: 2022).

Authors:

Abstract: Thymic epithelium is critical for the structural integrity of the thymus and for T cell development. Within the fully formed thymus, large numbers of hematopoietic cells shape the thymic epithelium into a scaffold-like structure which bears little simi...

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Unveiling the Toxicity of Fine and Nano-Sized Airborne Particles Generated from Industrial Thermal Spraying Processes in Human Alveolar Epithelial Cells.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Apr 13; Vol. 23 (8). Date of Electronic Publication: 2022 Apr 13.

Abstract: High-energy industrial processes have been associated with particle release into workplace air that can adversely affect workers' health. The present study assessed the toxicity of incidental fine (PGFP) and nanoparticles (PGNP) emitted from atmospheri...

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Organoid-based expansion of patient-derived primary alveolar type 2 cells for establishment of alveolus epithelial Lung-Chip cultures.

Publication Type: Academic Journal

Source(s): American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2022 Apr 01; Vol. 322 (4), pp. L526-L538. Date of Electronic Publication: 2022 Feb 09.

Abstract: Development of effective treatment strategies for lung tissue destruction as seen in emphysema would greatly benefit from representative human in vitro models of the alveolar compartment. Studying how cellular cross talk and/or (altered) biomechanical ...

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Alveolar cells in the mammary gland: lineage commitment and cell death.

Publication Type: Academic Journal

Source(s): The Biochemical journal [Biochem J] 2022 May 13; Vol. 479 (9), pp. 995-1006.

Authors:

Abstract: The mammary gland provides a spectacular example of physiological cell death whereby the cells that produce milk during lactation are removed swiftly, efficiently, and without inducing inflammation upon the cessation of lactation. The milk-producing ce...

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Lung Extracellular Matrix Hydrogels Enhance Preservation of Type II Phenotype in Primary Alveolar Epithelial Cells.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Apr 28; Vol. 23 (9). Date of Electronic Publication: 2022 Apr 28.

Abstract: One of the main limitations of in vitro studies on lung diseases is the difficulty of maintaining the type II phenotype of alveolar epithelial cells in culture. This fact has previously been related to the translocation of the mechanosensing Yes-associ...

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