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Advanced Search Results For "EXCHANGE"

1 - 10 of 983,855 results for
 "EXCHANGE"
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Influence of ligand density variations on the two peak elution behavior of a monoclonal antibody in cation exchange chromatography.

Publication Type:Academic Journal

Source(s):Journal of chromatography. A [J Chromatogr A] 2022 Sep 13; Vol. 1680, pp. 463410. Date of Electronic Publication: 2022 Aug 09.

Abstract:Cation exchange chromatography, as part of the monoclonal antibody purification train, is known as a mild polishing technique. However, in the last couple of years, more and more publications have shown unusual elution behavior, resulting from e.g. on-...

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Boron recovery from desalination seawater brines by selective ion exchange resins.

Publication Type:Academic Journal

Source(s):Journal of environmental management [J Environ Manage] 2022 Jul 15; Vol. 314, pp. 114984. Date of Electronic Publication: 2022 Apr 14.

Abstract:The European Union (EU) depends on third markets to supply many important raw materials. Increasing the circularity of critical raw materials within the EU is important not only from an environmental perspective, but also as a competitive advantage for...

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A multifaceted strategy to improve recombinant expression and structural characterisation of a Trypanosoma invariant surface protein.

Publication Type:Academic Journal

Source(s):Scientific reports [Sci Rep] 2022 Jul 26; Vol. 12 (1), pp. 12706. Date of Electronic Publication: 2022 Jul 26.

Abstract:Identification of a protein minimal fragment amenable to crystallisation can be time- and labour intensive especially if large amounts are required and the protein has a complex fold and functionally important post-translational modifications. In addit...

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Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude.

Publication Type:Academic Journal

Source(s):Cell reports [Cell Rep] 2022 Jul 12; Vol. 40 (2), pp. 111080.

Abstract:How protein signaling networks respond to different input strengths is an important but poorly understood problem in cell biology. For example, RhoA can promote focal adhesion (FA) growth or disassembly, but how RhoA activity mediates these opposite ou...

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Characterization and computational simulation of human Syx, a RhoGEF implicated in glioblastoma.

Publication Type:Academic Journal

Source(s):FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2022 Jul; Vol. 36 (7), pp. e22378.

Abstract:Structural discovery of guanine nucleotide exchange factor (GEF) protein complexes is likely to become increasingly relevant with the development of new therapeutics targeting small GTPases and development of new classes of small molecules that inhibit...

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Screening of six cation exchange resins for high binding capacity, monomer purity and step yield: A case study.

Publication Type:Academic Journal

Source(s):Protein expression and purification [Protein Expr Purif] 2022 Nov; Vol. 199, pp. 106155. Date of Electronic Publication: 2022 Aug 12.

Abstract:Cation exchange (CEX) chromatography has been widely used as a polishing step in downstream processing of therapeutic monoclonal antibodies (mAbs). It has been well documented that the performance of a particular CEX resin heavily relies on buffer type...

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Dissociation events during processing of monoclonal antibodies on strong cation exchange resins.

Publication Type:Academic Journal

Source(s):Journal of chromatography. A [J Chromatogr A] 2022 May 10; Vol. 1670, pp. 462969. Date of Electronic Publication: 2022 Mar 20.

Abstract:The phenomenon of pH excursion was demonstrated for pH gradient elution of monoclonal antibodies (mAbs) on strong cation exchange resins under high overloading conditions. The mAbs differed in molecular structure and isoelectric point, and the resins i...

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Cation exchange as a single polishing step for conjugated peptides.

Publication Type:Academic Journal

Source(s):Biotechnology progress [Biotechnol Prog] 2022 May; Vol. 38 (3), pp. e3238. Date of Electronic Publication: 2022 Feb 04.

Abstract:Purification of peptides typically includes expensive reverse phase (RP) processes, which utilize high pressure and large volumes of solvent. For two conjugated peptides, chromatography process development targeted a low-pressure aqueous process that c...

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Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics under Physiological Conditions.

Publication Type:Academic Journal

Source(s):Journal of visualized experiments : JoVE [J Vis Exp] 2022 Jun 23 (184). Date of Electronic Publication: 2022 Jun 23.

Abstract:Alpha-synuclein (aSyn) is an intrinsically disordered protein whose fibrillar aggregates are abundant in Lewy bodies and neurites, which are the hallmarks of Parkinson's disease. Yet, much of its biological activity, as well as its aggregation, central...

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Gas-Free Continuously Regenerated Impurity Removal Device for Ion Chromatography.

Publication Type:Academic Journal

Source(s):Analytical chemistry [Anal Chem] 2022 May 17; Vol. 94 (19), pp. 6924-6929. Date of Electronic Publication: 2022 May 03.

Abstract:A gas-free continuously regenerated-anion impurity removal device (CR-ARD) is described for ion chromatography (IC). It is a sandwiched configuration consisting of three channels. The central eluent channel is isolated from two outer regenerant channel...

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