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Advanced Search Results For "EXPORTS"

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 "EXPORTS"
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Crystallization of Nuclear Export Signals or Small-Molecule Inhibitors Bound to Nuclear Exporter CRM1.

Publication Type:Academic Journal

Source(s):Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2502, pp. 285-297.

Abstract:The Karyopherin protein CRM1 or XPO1 is the major nuclear export receptor that regulates nuclear exit of thousands of macromolecules in the cell. CRM1 recognizes protein cargoes by binding to their 8-15 residue-long nuclear export signals (NESs). A ter...

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Binding Affinity Measurement of Nuclear Export Signal Peptides to Their Exporter CRM1.

Publication Type:Academic Journal

Source(s):Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2502, pp. 245-256.

Abstract:CRM1 recognizes hundreds to thousands of protein cargoes by binding to the eight to fifteen residue-long nuclear export signals (NESs) within their polypeptide chains. Various assays to measure the binding affinity of NESs for CRM1 have been developed....

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Machine Learning to Assess Relatedness: The Advantage of Using Firm-Level Data.

Publication Type:Academic Journal

Source(s):Complexity. 7/31/2022, p1-12. 12p.

Abstract:The relatedness between a country or a firm and a product is a measure of the feasibility of that economic activity. As such, it is a driver for investments at a private and institutional level. Traditionally, relatedness is measured using networks der...

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Behavior Patterns of Three Archetypal Arms Suppliers Based on Empirical Media Analysis of the First Korean Fighter Jet Program.

Publication Type:Academic Journal

Source(s):International Journal of Business. 2022, Vol. 27 Issue 3, p1-18. 18p.

Abstract:Understanding the arms suppliers' strategic intent will contribute to the recipient's agenda-setting efforts. Previous studies address the three types of patterns in their arms export policymaking regarding suppliers' policy objectives: hegemonic, indu...

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RanGTPase links nucleo-cytoplasmic transport to the recruitment of cargoes into small extracellular vesicles.

Publication Type:Academic Journal

Source(s):Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2022 Jul 02; Vol. 79 (7), pp. 392. Date of Electronic Publication: 2022 Jul 02.

Abstract:Small extracellular vesicle (sEV)-mediated intercellular communication regulates multiple aspects of growth and development in multicellular organisms. However, the mechanism underlying cargo recruitment into sEVs is currently unclear. We show that the...

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Protocol for nuclear export signal characterization of cGAS in mammalian cells.

Publication Type:Academic Journal

Source(s):STAR protocols [STAR Protoc] 2021 Jul 03; Vol. 2 (3), pp. 100649. Date of Electronic Publication: 2021 Jul 03 (Print Publication: 2021).

Abstract:The cyclic GMP-AMP synthase (cGAS) is the principal DNA sensor, which binds DNA and triggers the type I interferon production. We used ISD45 or inactivated Vaccinia Virus (VACV) to stimulate cGAS and monitored cellular localization by immunofluorescenc...

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A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.

Publication Type:Academic Journal

Source(s):Cell reports [Cell Rep] 2021 Jan 05; Vol. 34 (1), pp. 108586.

Abstract:The cyclic GMP-AMP (cGAMP) synthase (cGAS) is a key DNA sensor that initiates STING-dependent signaling to produce type I interferons through synthesizing the secondary messenger 2'3'-cGAMP. In this study, we confirm previous studies showing that cGAS ...

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