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AMG232 inhibits angiogenesis in glioma through the p53-RBM4-VEGFR2 pathway.
Publication Type: Academic Journal
Source(s): Journal of cell science [J Cell Sci] 2023 Jan 15; Vol. 136 (2). Date of Electronic Publication: 2023 Jan 27.
Abstract: AMG232 effectively inhibits cancers with wild-type p53 (also known as TP53) by reactivating p53, but whether it inhibits glioma angiogenesis remains unclear. This study confirms that AMG232 inhibits the proliferation of glioma endothelial cells (GECs) ...
A relatively low glucose promotes the proliferation of vascular endothelial cells by suppressing VEGFR2 O-GlcNAcylation and its proteasome degradation.
Publication Type: Academic Journal
Source(s): International ophthalmology [Int Ophthalmol] 2023 Mar; Vol. 43 (3), pp. 899-914. Date of Electronic Publication: 2022 Sep 12.
Abstract: Purpose: Vascular endothelial growth factor receptors (VEGFRs) have been demonstrated to play a critical role in ischemic retinal diseases, as VEGFRs mediate hypoxia-induced neovascularization. Not only hypoxia, ischemia also induces the deficiency of ...
Origin, prospective identification, and function of circulating endothelial colony-forming cells in mice and humans.
Publication Type: Academic Journal
Source(s): JCI insight [JCI Insight] 2023 Mar 08; Vol. 8 (5). Date of Electronic Publication: 2023 Mar 08.
Abstract: Most circulating endothelial cells are apoptotic, but rare circulating endothelial colony-forming cells (C-ECFCs), also known as blood outgrowth endothelial cells, with proliferative and vasculogenic activity can be cultured; however, the origin and na...
Rheum rhaponticum and Rheum rhabarbarum Extracts as Modulators of Endothelial Cell Inflammatory Response.
Publication Type: Academic Journal
Source(s): Nutrients [Nutrients] 2023 Feb 14; Vol. 15 (4). Date of Electronic Publication: 2023 Feb 14.
Abstract: Background: Inflammation, endothelial dysfunction, and alterations in blood physiology are key factors contributing to atherosclerosis and other cardiovascular disorders. Hence, modulation of endothelial function and reducing its pro-inflammatory and p...
m6A Modification Mediates Endothelial Cell Responses to Oxidative Stress in Vascular Aging Induced by Low Fluid Shear Stress.
Publication Type: Academic Journal
Source(s): Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2023 Jan 27; Vol. 2023, pp. 8134027. Date of Electronic Publication: 2023 Jan 27 (Print Publication: 2023).
Abstract: N6-methyladenosine (m6A) is one of the most prevalent, abundant, and internal transcriptional modification and plays essential roles in diverse cellular and physiological processes. Low fluid shear stress (FSS) is a key pathological factor for many car...
SYP-3343 drives abnormal vascularization in zebrafish through regulating endothelial cell behavior.
Publication Type: Academic Journal
Source(s): Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2023 Apr; Vol. 174, pp. 113671. Date of Electronic Publication: 2023 Feb 14.
Abstract: SYP-3343 is a novel strobilurin fungicide with excellent and broad-spectrum antifungal activity, and its potential toxicity raises public health concerns. However, the vascular toxicity of SYP-3343 to zebrafish embryos is still not well understood. In ...
SDF‑1α/CXCR4 signaling promotes capillary tube formation of human retinal vascular endothelial cells by activating ERK1/2 and PI3K pathways in vitro .
Publication Type: Academic Journal
Source(s): Molecular medicine reports [Mol Med Rep] 2022 Oct; Vol. 26 (4). Date of Electronic Publication: 2022 Aug 10.
Abstract: The purpose of this study is to address the effect and mechanism of stromal cell‑derived factor‑1 (SDF‑1)α/chemokine (C‑X‑C motif) receptor 4 (CXCR4) signaling on capillary tube formation of human retinal vascular endothelial cells (HRECs). The express...
Angiogenesis-Browning Interplay Mediated by Asprosin-Knockout Contributes to Weight Loss in Mice with Obesity.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Dec 18; Vol. 23 (24). Date of Electronic Publication: 2022 Dec 18.
Abstract: Asprosin (ASP) is a recently identified adipokine secreted by white adipose tissue (WAT). It plays important roles in the maintenance of glucose homeostasis in the fasting state and in the occurrence and development of obesity. However, there is no rep...
Liver receptor homolog 1 (LRH-1) regulates follicle vasculature during ovulation in mice.
Publication Type: Academic Journal
Source(s): Reproduction (Cambridge, England) [Reproduction] 2022 Nov 07; Vol. 164 (6), pp. 283-289. Date of Electronic Publication: 2022 Nov 07 (Print Publication: 2022).
Abstract: In Brief: It is well-established that liver receptor homolog 1 (LRH-1/NR5A2) regulates the ovarian function and is required for ovulation and luteinization in mice. In the present experiment, we showed that LRH-1 is required to control vascular changes...
Extracellular matrix derived from Wharton's Jelly-derived mesenchymal stem cells promotes angiogenesis via integrin αVβ3/c-Myc/P300/VEGF.
Publication Type: Academic Journal
Source(s): Stem cell research & therapy [Stem Cell Res Ther] 2022 Jul 18; Vol. 13 (1), pp. 327. Date of Electronic Publication: 2022 Jul 18.
Abstract: Background: Angiogenesis is required in many physiological conditions, including bone regeneration, wound healing, and tissue regeneration. Mesenchymal stem cells-derived extracellular matrix (MSCs-ECM) could guide intricate cellular and tissue process...