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Enhanced blend uniformity and flowability of low drug loaded fine API blends via dry coating: The effect of mixing time and excipient size.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Mar 25; Vol. 635, pp. 122722. Date of Electronic Publication: 2023 Feb 14.
Abstract: Although previous research demonstrated improved flowability, packing, fluidization, etc. of individual powders via nanoparticle dry coating, none considered its impact on very low drug loaded blends. Here, fine ibuprofen at 1, 3, and 5Â wt% drug loadin...
Increasing β-carotene bioavailability and bioactivity in spinach demonstrated using excipient nanoemulsions-especially those of long-chain triglycerides.
Publication Type: Academic Journal
Source(s): Food chemistry [Food Chem] 2023 Mar 15; Vol. 404 (Pt B), pp. 134194. Date of Electronic Publication: 2022 Sep 12.
Abstract: This study sought to improve the biological fate of β-carotene obtained from spinach, using in vitro digestion, in situ single-pass intestinal perfusion, and in vivo approaches, to investigate the effects of excipient emulsions with medium- (MCT) and l...
Excipient Taxonomy for the 21st Century.
Publication Type: Academic Journal
Source(s): Journal of pharmaceutical sciences [J Pharm Sci] 2023 Mar; Vol. 112 (3), pp. 626-633. Date of Electronic Publication: 2022 Dec 13.
Abstract: The performance of pharmaceutical dosage forms relies heavily on the characteristics of the excipients that are incorporated into the drug product during the manufacturing process. Therefore, it is imperative that formulators are able to accurately and...
Orally disintegrating drug carriers for paediatric pharmacotherapy.
Publication Type: Academic Journal
Source(s): European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2023 Mar 01; Vol. 182, pp. 106377. Date of Electronic Publication: 2023 Jan 10.
Abstract: Non-compliance, dosing inaccuracy, choking risk, flavour, and instability, are some of the issues associated with paediatric, oral dosage forms - tablets, capsules, solutions, and suspensions. Orally disintegrating drug carriers, a dosage form with gro...
Relative Humidity Cycling: Implications on the Stability of Moisture-Sensitive Drugs in Solid Pharmaceutical Products.
Publication Type: Academic Journal
Source(s): Molecular pharmaceutics [Mol Pharm] 2023 Feb 06; Vol. 20 (2), pp. 1072-1085. Date of Electronic Publication: 2022 Dec 08.
Abstract: The stability of a moisture-sensitive drug in tablet formulations depends particularly on the environment's relative humidity (RH) and the products' prior exposure to moisture. This study was designed to understand drug stability in relation to the moi...
Random Heteropolymer Excipients Improve the Colloidal Stability of a Monoclonal Antibody for Subcutaneous Administration.
Publication Type: Academic Journal
Source(s): Pharmaceutical research [Pharm Res] 2023 Feb; Vol. 40 (2), pp. 525-536. Date of Electronic Publication: 2022 Nov 15.
Abstract: Purpose: Developing stable high concentration monoclonal antibody (mAb) formulations is increasingly important to move toward subcutaneous (SC) administration for better patient experience. Challenges stemming from protein-protein interactions in these...
In Vitro-In Vivo Study of the Impact of Excipient Emulsions on the Bioavailability and Antioxidant Activity of Flavonoids: Influence of the Carrier Oil Type.
Publication Type: Academic Journal
Source(s): Journal of agricultural and food chemistry [J Agric Food Chem] 2023 Jan 25; Vol. 71 (3), pp. 1488-1498. Date of Electronic Publication: 2022 Dec 29.
Abstract: The influence of the carrier oil type on the bioavailability and bioactivity of flavonoids (quercetin, kaempferol, and apigenin) was examined using in vitro digestion, in situ intestinal perfusion, and pharmacokinetic studies. Here, medium-chain trigly...
Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Jan 05; Vol. 630, pp. 122463. Date of Electronic Publication: 2022 Nov 30.
Abstract: COVID-19 is caused by the infection of the lungs by SARS-CoV-2. Monoclonal antibodies, such as sotrovimab, showed great efficiency in neutralizing the virus before its internalization by lung epithelial cells. However, parenteral routes are still the p...
The Effect of In-Situ-Generated Moisture on Disproportionation of Pharmaceutical Salt.
Publication Type: Academic Journal
Source(s): Molecular pharmaceutics [Mol Pharm] 2023 Jan 02; Vol. 20 (1), pp. 561-571. Date of Electronic Publication: 2022 Dec 16.
Abstract: Pharmaceutical salts are ubiquitously present in the market given their benefits in optimizing the critical properties of an active pharmaceutical ingredient (API). Achieving these benefits requires careful selection and understanding of the salt form ...
Two peak elution behavior of a monoclonal antibody in cation exchange chromatography as a screening tool for excipients.
Publication Type: Academic Journal
Source(s): Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2023 Jan 01; Vol. 1214, pp. 123563. Date of Electronic Publication: 2022 Dec 07.
Abstract: Aggregation of proteins is a critical quality attribute and a major concern during the purification of therapeutic proteins, like monoclonal antibodies. In-solution experiments applying different stress scenarios, e.g., mechanical, or physical stresses...