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Optical photothermal infrared spectroscopy for nanochemical analysis of pharmaceutical dry powder aerosols.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Feb 05; Vol. 632, pp. 122563. Date of Electronic Publication: 2022 Dec 28.
Abstract: The aim of this research was to chemically analyse the distribution of drugs and excipients in pharmaceutical dry powder inhalation (DPI) aerosol particles of various sizes in solid state. The conventional wet assay of the chemical composition of parti...
Optimising nasal powder drug delivery - Characterisation of the effect of excipients on drug absorption.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Feb 25; Vol. 633, pp. 122630. Date of Electronic Publication: 2023 Jan 20.
Abstract: The nasal physiology offers great potential for drug delivery but also poses specific challenges, among which the short residence time of applied drugs is one of the most striking. Formulating the drug as powder and using functional excipients are stra...
Enhanced blend uniformity and flowability of low drug loaded fine API blends via dry coating: The effect of mixing time and excipient size.
Publication Type: Academic Journal
Source(s): International journal of pharmaceutics [Int J Pharm] 2023 Mar 25; Vol. 635, pp. 122722. Date of Electronic Publication: 2023 Feb 14.
Abstract: Although previous research demonstrated improved flowability, packing, fluidization, etc. of individual powders via nanoparticle dry coating, none considered its impact on very low drug loaded blends. Here, fine ibuprofen at 1, 3, and 5 wt% drug loadin...
Microfluidic Particle Engineering of Hydrophobic Drug with Eudragit E100─Bridging the Amorphous and Crystalline Gap.
Publication Type: Academic Journal
Source(s): Molecular pharmaceutics [Mol Pharm] 2022 Nov 07; Vol. 19 (11), pp. 4345-4356. Date of Electronic Publication: 2022 Oct 21.
Abstract: Co-processing active pharmaceutical ingredients (APIs) with excipients is a promising particle engineering technique to improve the API physical properties, which can lead to more robust downstream drug product manufacturing and improved drug product a...
Enhancement of ketoprofen dissolution rate by the liquisolid technique: optimization and in vitro and in vivo investigations.
Publication Type: Academic Journal
Source(s): Drug delivery and translational research [Drug Deliv Transl Res] 2022 Nov; Vol. 12 (11), pp. 2693-2707. Date of Electronic Publication: 2022 Feb 17.
Abstract: The objective of the current study is to evaluate the prospective of liquisolid formulation to improve the dissolution rate of ketoprofen and thereby the bioavailability. Different batches of liquisolid were prepared using polyethylene glycol 200 as a ...
Machine Learning-Enabled NIR Spectroscopy in Assessing Powder Blend Uniformity: Clear-Up Disparities and Biases Induced by Physical Artefacts.
Publication Type: Academic Journal
Source(s): AAPS PharmSciTech [AAPS PharmSciTech] 2022 Oct 13; Vol. 23 (7), pp. 277. Date of Electronic Publication: 2022 Oct 13.
Abstract: NIR spectroscopy is a non-destructive characterization tool for the blend uniformity (BU) assessment. However, NIR spectra of powder blends often contain overlapping physical and chemical information of the samples. Deconvoluting the information relate...
Pharmaceutical Product Characterization and Manufacturability of Surfactant-Enriched Oil Marbles with Abiraterone Acetate.
Publication Type: Academic Journal
Source(s): AAPS PharmSciTech [AAPS PharmSciTech] 2022 Oct 07; Vol. 23 (7), pp. 274. Date of Electronic Publication: 2022 Oct 07.
Abstract: The present study investigates the physicochemical properties and stability of a novel lipid-based formulation-surfactant-enriched oil marbles containing abiraterone acetate. While the biopharmaceutical performance of this formulation has been reported...
Excipient Taxonomy for the 21st Century.
Publication Type: Academic Journal
Source(s): Journal of pharmaceutical sciences [J Pharm Sci] 2023 Mar; Vol. 112 (3), pp. 626-633. Date of Electronic Publication: 2022 Dec 13.
Abstract: The performance of pharmaceutical dosage forms relies heavily on the characteristics of the excipients that are incorporated into the drug product during the manufacturing process. Therefore, it is imperative that formulators are able to accurately and...
Relative Humidity Cycling: Implications on the Stability of Moisture-Sensitive Drugs in Solid Pharmaceutical Products.
Publication Type: Academic Journal
Source(s): Molecular pharmaceutics [Mol Pharm] 2023 Feb 06; Vol. 20 (2), pp. 1072-1085. Date of Electronic Publication: 2022 Dec 08.
Abstract: The stability of a moisture-sensitive drug in tablet formulations depends particularly on the environment's relative humidity (RH) and the products' prior exposure to moisture. This study was designed to understand drug stability in relation to the moi...
In Vitro-In Vivo Study of the Impact of Excipient Emulsions on the Bioavailability and Antioxidant Activity of Flavonoids: Influence of the Carrier Oil Type.
Publication Type: Academic Journal
Source(s): Journal of agricultural and food chemistry [J Agric Food Chem] 2023 Jan 25; Vol. 71 (3), pp. 1488-1498. Date of Electronic Publication: 2022 Dec 29.
Abstract: The influence of the carrier oil type on the bioavailability and bioactivity of flavonoids (quercetin, kaempferol, and apigenin) was examined using in vitro digestion, in situ intestinal perfusion, and pharmacokinetic studies. Here, medium-chain trigly...