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Advanced Search Results For "FIBROBLASTS"

1 - 10 of 249,490 results for
 "FIBROBLASTS"
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Inhibition of FGFR Signaling by Targeting FGF/FGFR Extracellular Interactions: Towards the Comprehension of the Molecular Mechanism through NMR Approaches.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Sep 17; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 17.

Abstract: NMR-based approaches play a pivotal role in providing insight into molecular recognition mechanisms, affording the required atomic-level description and enabling the identification of promising inhibitors of protein-protein interactions. The aberrant a...

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Senescent Fibroblasts Generate a CAF Phenotype through the Stat3 Pathway.

Publication Type: Academic Journal

Source(s): Genes [Genes (Basel)] 2022 Sep 02; Vol. 13 (9). Date of Electronic Publication: 2022 Sep 02.

Authors:

Abstract: Aging has been recently reported to promote lung cancer initiation and progression. Senescent fibroblasts gain a cancer-associated fibroblast (CAF) phenotype, and exert a powerful influence on cancer behavior, such as tumor cell growth and metastasis. ...

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Type 2 Diabetes Mellitus Promotes the Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells into Cancer-Associated Fibroblasts, Induced by Breast Cancer Cells.

Publication Type: Academic Journal

Source(s): Stem cells and development [Stem Cells Dev] 2022 Nov; Vol. 31 (21-22), pp. 659-671. Date of Electronic Publication: 2022 Jul 30.

Abstract: Triple-negative breast cancer (TNBC) is a highly aggressive and invasive type of breast cancer. In addition, type 2 diabetes mellitus (T2DM) is recognized as a risk factor for cancer metastasis, which is associated with mortality in patients with breas...

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CD36 + Fibroblasts Secrete Protein Ligands That Growth-Suppress Triple-Negative Breast Cancer Cells While Elevating Adipogenic Markers for a Model of Cancer-Associated Fibroblast.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Oct 22; Vol. 23 (21). Date of Electronic Publication: 2022 Oct 22.

Abstract: Tumor and stroma coevolve to facilitate tumor growth. Hence, effective tumor therapeutics would not only induce growth suppression of tumor cells but also revert pro-tumor stroma into anti-tumoral type. Previously, we showed that coculturing triple-neg...

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Autocrine FGF1 signaling promotes glucose uptake in adipocytes.

Publication Type: Academic Journal

Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Oct 04; Vol. 119 (40), pp. e2122382119. Date of Electronic Publication: 2022 Sep 26.

Abstract: Fibroblast growth factor 1 (FGF1) is an autocrine growth factor released from adipose tissue during over-nutrition or fasting to feeding transition. While local actions underlie the majority of FGF1's anti-diabetic functions, the molecular mechanisms d...

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Cancer-associated fibroblasts: Vital suppressors of the immune response in the tumor microenvironment.

Publication Type: Academic Journal

Source(s): Cytokine & growth factor reviews [Cytokine Growth Factor Rev] 2022 Oct; Vol. 67, pp. 35-48. Date of Electronic Publication: 2022 Jul 22.

Abstract: Since the "seed and soil" hypothesis was proposed, the biological functions of the tumor microenvironment (TME), especially its stromal components, have received increasing attention. Cancer-associated fibroblasts (CAFs) are the major components of the...

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Cancer-associated fibroblasts in nonsmall cell lung cancer: From molecular mechanisms to clinical implications.

Publication Type: Academic Journal

Source(s): International journal of cancer [Int J Cancer] 2022 Oct 15; Vol. 151 (8), pp. 1195-1215. Date of Electronic Publication: 2022 Jun 08.

Abstract: Lung cancer is the common and leading cause of cancer death worldwide. The tumor microenvironment has been recognized to be instrumental in tumorigenesis. To have a deep understanding of the molecular mechanism of nonsmall cell lung carcinoma (NSCLC), ...

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Effects of urinary extracellular vesicles from prostate cancer patients on the transcriptomes of cancer-associated and normal fibroblasts.

Publication Type: Academic Journal

Source(s): BMC cancer [BMC Cancer] 2022 Oct 12; Vol. 22 (1), pp. 1055. Date of Electronic Publication: 2022 Oct 12.

Abstract: Background: Increasing evidence suggests that cancer-derived extracellular vesicles (EVs) alter the phenotype and functions of fibroblasts and trigger the reprogramming of normal fibroblasts into cancer-associated fibroblasts (CAFs). Here, we for the f...

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Cancer-associated fibroblast-like fibroblasts in vocal fold leukoplakia suppress CD8 + T cell functions by inducing IL-6 autocrine loop and interacting with Th17 cells.

Publication Type: Academic Journal

Source(s): Cancer letters [Cancer Lett] 2022 Oct 10; Vol. 546, pp. 215839. Date of Electronic Publication: 2022 Aug 10.

Authors:

Abstract: The characteristics of fibroblast cells in head and neck precancerous lesion and its ability to secrete inflammatory cytokines and affect CD8 + T cell functions remain unclear. Herein, we reported the existence of fibroblasts in human-derived vocal fol...

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FGF15 promotes hepatic NPC1L1 degradation in lithogenic diet-fed mice.

Publication Type: Academic Journal

Source(s): Lipids in health and disease [Lipids Health Dis] 2022 Oct 08; Vol. 21 (1), pp. 97. Date of Electronic Publication: 2022 Oct 08.

Authors:

Abstract: Background: Cholesterol gallstone disease (CGD) is accompanied by biliary cholesterol supersaturation. Hepatic Niemann-Pick C1-like 1 (NPC1L1), which is present in humans but not in wild-type (WT) mice, promotes hepatocyte cholesterol uptake and decrea...

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