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MiR-146a encapsulated liposomes reduce vascular inflammatory responses through decrease of ICAM-1 expression, macrophage activation, and foam cell formation.
Publication Type: Academic Journal
Source(s): Nanoscale [Nanoscale] 2023 Feb 16; Vol. 15 (7), pp. 3461-3474. Date of Electronic Publication: 2023 Feb 16.
Abstract: Vascular insults can create an inflammatory cascade involving endothelial cell, smooth muscle cell, and macrophage activation which can eventually lead to vascular disease such as atherosclerosis. Several studies have identified microRNA 146a's (miR-14...
Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPARγ/LXRα/ABCA1 Pathway.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jan 20; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 20.
Abstract: Cholesterol accumulation in macrophages leads to the formation of foam cells and increases the risk of developing atherosclerosis. We have verified whether hydroxytyrosol (HT), a phenolic compound with anti-inflammatory and antioxidant properties, can ...
Ractopamine at legal residue dosage accelerates atherosclerosis by inducing endothelial dysfunction and promoting macrophage foam cell formation.
Publication Type: Academic Journal
Source(s): Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2022 Nov 15; Vol. 313, pp. 120080. Date of Electronic Publication: 2022 Aug 31.
Abstract: Ractopamine, a synthetic β-adrenoreceptor agonist, is used as an animal feed additive to increase food conversion efficiency and accelerate lean mass accretion in farmed animals. The U.S. Food and Drug Administration claimed that ingesting products con...
Diaporisoindole B Reduces Lipid Accumulation in THP-1 Macrophage Cells via MAPKs and PPARγ-LXRα Pathways and Promotes the Reverse Cholesterol Transport by Upregulating SR-B1 and LDLR in HepG2 Cells.
Publication Type: Academic Journal
Source(s): Journal of natural products [J Nat Prod] 2022 Dec 23; Vol. 85 (12), pp. 2769-2778. Date of Electronic Publication: 2022 Nov 18.
Abstract: Diaporisoindole B (DPB), an isoprenylisoindole alkaloid isolated from the mangrove endophytic fungus Diaporthe sp. SYSU-HQ3, has been proved to have a good anti-inflammatory activity in macrophage cells. In this study, we found that DPB was able to red...
Cyclophilin A accelerates SiO 2 -induced macrophage foaming.
Publication Type: Academic Journal
Source(s): Cellular signalling [Cell Signal] 2023 Mar; Vol. 103, pp. 110562. Date of Electronic Publication: 2022 Dec 16.
Abstract: Silicosis is a common occupational disease characterized by lung inflammation, fibrosis and pulmonary dysfunction caused by long-term inhalation of free SiO 2 . Cell foaming and the change of CyPA have been observed in SiO 2 -induced macrophages, but t...
Expression of SR-BI and LXR α in Macrophage Origin Foam Cells of Mouse RAW264.7 Up-regulated by Astragalus Polysaccharide.
Publication Type: Academic Journal
Source(s): Contrast media & molecular imaging [Contrast Media Mol Imaging] 2022 Sep 27; Vol. 2022, pp. 3920584. Date of Electronic Publication: 2022 Sep 27 (Print Publication: 2022).
Abstract: Objective: To investigate the influences of Astragalus polysaccharides (APS) on the expressions of SR-BI(Scavenger receptor-BI) and LXR α in RAW264.7 macrophage origin foam cells.Methods: Mouse RAW264.7 cells were induced in foam cells and identificati...
Differential Expression of Inflammarafts in Macrophage Foam Cells and in Nonfoamy Macrophages in Atherosclerotic Lesions-Brief Report.
Publication Type: Academic Journal
Source(s): Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2023 Feb; Vol. 43 (2), pp. 323-329. Date of Electronic Publication: 2022 Dec 01.
Abstract: Background: Reprogramming of monocytes and macrophage manifests in hyperinflammatory responses and chronification of inflammation in atherosclerosis. Recent studies focused on epigenetic, transcriptional, and metabolic alterations that characterize tra...
Long noncoding RNA THRIL promotes foam cell formation and inflammation in macrophages.
Publication Type: Academic Journal
Source(s): Cell biology international [Cell Biol Int] 2023 Jan; Vol. 47 (1), pp. 156-166. Date of Electronic Publication: 2022 Oct 13.
Abstract: Tumor necrosis factor-α (TNF-α) and heterogenous nuclear ribonucleoprotein L (hnRNPL)-related immunoregulatory lincRNA (THRIL) is a long noncoding RNA (lncRNA) involved in various inflammatory diseases. However, its role in atherosclerosis is not known...
Benzotriazole ultraviolet stabilizer UV-234 promotes foam cell formation in RAW264.7 macrophages.
Publication Type: Academic Journal
Source(s): Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2023 Jan 01; Vol. 316 (Pt 1), pp. 120560. Date of Electronic Publication: 2022 Oct 31.
Abstract: Benzotriazole ultraviolet stabilizers (BUVSs) have been reported to induce inflammatory responses which may promote cholesterol accumulation and to downregulate the expression of genes involved in cholesterol biosynthesis; hence, we speculated whether ...
Rutin Inhibits Ox-LDL-Mediated Macrophage Inflammation and Foam Cell Formation by Inducing Autophagy and Modulating PI3K/ATK Signaling.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2022 Jun 29; Vol. 27 (13). Date of Electronic Publication: 2022 Jun 29.
Abstract: Atherosclerosis (AS) is one of the leading causes of death among the elderly, and is primarily caused by foam cell generation and macrophage inflammation. Rutin is an anti-inflammatory, anti-oxidant, anti-allergic, and antiviral flavonoid molecule, kno...