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CCNE1 Amplification as a Therapeutic Target.
Publication Type: Academic Journal
Source(s): Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2023 Mar 20; Vol. 41 (9), pp. 1770-1773. Date of Electronic Publication: 2023 Feb 02.
E2F3 gene expression is a potential negative prognostic marker for localised and MYCN not-amplified neuroblastoma: Results of in silico analysis of 786 samples.
Publication Type: Academic Journal
Source(s): Pediatric blood & cancer [Pediatr Blood Cancer] 2022 Oct; Vol. 69 (10), pp. e29800. Date of Electronic Publication: 2022 Jun 02.
Abstract: Background: Neuroblastoma (NB) is an enigmatic childhood malignancy characterised by a wide range of clinical behaviour. Many potential oncogenes for NB have recently been identified. Among them, E2 transcription factor 3 (E2F3) expression was associat...
Superficial GLI1-amplified mesenchymal neoplasms: Expanding the spectrum of an emerging entity which reaches the realm of dermatopathology.
Publication Type: Report
Source(s): Journal of cutaneous pathology [J Cutan Pathol] 2023 Jun; Vol. 50 (6), pp. 487-499. Date of Electronic Publication: 2022 Nov 23.
Abstract: Mesenchymal neoplasms with GLI1 alterations (rearrangements and/or amplification) have been reported recently in several anatomic locations, which include head and neck, soft tissue, and gastrointestinal tract. Herein, to the best of our knowledge, we ...
A rare radiotherapy-sensitive primitive neuroectodermal tumor with APC gene amplification in an adult: a case report and literature review.
Publication Type: Academic Journal
Source(s): The Journal of international medical research [J Int Med Res] 2022 Aug; Vol. 50 (8), pp. 3000605221118704.
Abstract: Primitive neuroectodermal tumor (PNET) of the lung is rare in adults, and treatment options vary. We herein describe the disease course and follow-up of PNET in an adult. A 27-year-old man was admitted to our hospital because of cough and headache, and...
Genome-Wide Analysis of Palindrome Formation with Next-Generation Sequencing (GAPF-Seq) and a Bioinformatics Pipeline for Assessing De Novo Palindromes in Cancer Genomes.
Publication Type: Academic Journal
Source(s): Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2660, pp. 13-22.
Abstract: DNA palindromes are a type of chromosomal aberration that appears frequently during tumorigenesis. They are characterized by sequences of nucleotides that are identical to their reverse complements and often arise due to illegitimate repair of DNA doub...
Prognostic significance of CDK6 amplification in esophageal squamous cell carcinoma.
Publication Type: Academic Journal
Source(s): Cancer treatment and research communications [Cancer Treat Res Commun] 2023; Vol. 35, pp. 100698. Date of Electronic Publication: 2023 Mar 16.
Abstract: Dysregulation of CDK6 plays crucial roles in the carcinogenesis of many kinds of human malignancies. However, the role of CDK6 in esophageal squamous cell carcinoma (ESCC) is not well known. We investigated the frequency and prognostic value of CDK6 am...
Prominent Staining of MYCN Immunohistochemistry Predicts a Poor Prognosis in MYCN Non-Amplified Neuroblastoma.
Publication Type: Academic Journal
Source(s): Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society [Pediatr Dev Pathol] 2023 Mar-Apr; Vol. 26 (2), pp. 124-132. Date of Electronic Publication: 2023 Feb 12.
Abstract: Background: MYCN gene amplification is a powerful indicator of poor prognosis of neuroblastoma patients. However, MYCN non-amplified patients still showed heterogeneity in survival outcome. This study aimed to investigate the prognostic role of MYCN im...
Patterns of genomic change in residual disease after neoadjuvant chemotherapy for estrogen receptor-positive and HER2-negative breast cancer.
Publication Type: Academic Journal
Source(s): British journal of cancer [Br J Cancer] 2021 Nov; Vol. 125 (10), pp. 1356-1364. Date of Electronic Publication: 2021 Sep 03.
Abstract: Background: Treatment of patients with residual disease after neoadjuvant chemotherapy for breast cancer is an unmet clinical need. We hypothesised that tumour subclones showing expansion in residual disease after chemotherapy would contain mutations c...
RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Jan 02; Vol. 23 (1). Date of Electronic Publication: 2022 Jan 02.
Abstract: The RNA exosome is a multi-subunit ribonuclease complex that is evolutionally conserved and the major cellular machinery for the surveillance, processing, degradation, and turnover of diverse RNAs essential for cell viability. Here we performed integra...
MDM2 Gene Amplification and Expression of MDM2 and CDK4 are Rare in Ossifying Fibroma of Craniofacial Bones.
Publication Type: Academic Journal
Source(s): Head and neck pathology [Head Neck Pathol] 2022 Dec; Vol. 16 (4), pp. 991-997. Date of Electronic Publication: 2022 May 11.
Abstract: Ossifying fibroma of the craniofacial bones is a fibro-osseous lesion characterized by varied patterns of bone formation in a fibroblastic stroma. Ossifying fibroma is a putatively benign lesion with no reports of malignant transformation or metastasis...