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The potential causal association of systemic lupus erythematosus with congestive heart failure in the East Asian population: A two-sample mendelian randomization study.
Publication Type: Academic Journal
Source(s): Lupus [Lupus] 2023 Feb; Vol. 32 (2), pp. 295-298. Date of Electronic Publication: 2023 Jan 04.
Abstract: Objective: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that increases the risk of cardiovascular disease, but the causal relationship has remained unknown in the East Asian population. We aim to determine the causal relationship...
Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study.
Publication Type: Academic Journal
Source(s): BMC medicine [BMC Med] 2023 Apr 26; Vol. 21 (1), pp. 158. Date of Electronic Publication: 2023 Apr 26.
Abstract: Background: C-type natriuretic peptide (CNP) is a known target for promoting growth and has been implicated as a therapeutic opportunity for the prevention and treatment of cardiovascular disease (CVD). This study aimed to explore the effect of CNP on ...
Enterovirus D68 epidemic, UK, 2018, was caused by subclades B3 and D1, predominantly in children and adults, respectively, with both subclades exhibiting extensive genetic diversity.
Publication Type: Academic Journal
Source(s): Microbial genomics [Microb Genom] 2022 May; Vol. 8 (5).
Abstract: Enterovirus D68 (EV-D68) has recently been identified in biennial epidemics coinciding with diagnoses of non-polio acute flaccid paralysis/myelitis (AFP/AFM). We investigated the prevalence, genetic relatedness and associated clinical features of EV-D6...
Burden of Type 2 Diabetes and Associated Cardiometabolic Traits and Their Heritability Estimates in Endogamous Ethnic Groups of India: Findings From the INDIGENIUS Consortium.
Publication Type: Academic Journal
Source(s): Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Apr 14; Vol. 13, pp. 847692. Date of Electronic Publication: 2022 Apr 14 (Print Publication: 2022).
Abstract: To assess the burden of type 2 diabetes (T2D) and its genetic profile in endogamous populations of India given the paucity of data, we aimed to determine the prevalence of T2D and estimate its heritability using family-based cohorts from three distinct...
Genetic epidemiology of beta-thalassemia in the Maldives: 23 years of a beta-thalassemia screening program.
Publication Type: Academic Journal
Source(s): Gene [Gene] 2020 May 30; Vol. 741, pp. 144544. Date of Electronic Publication: 2020 Mar 09.
Abstract: The Maldives is an archipelago of 407,660 people according to population census of 2014, made up of 20 atolls, which has one of the highest prevalence of β-thalassemia worldwide. However, there is a dearth of studies related to β-thalassemia in the Mal...
GABA A subunit single nucleotide polymorphisms show sex-specific association to alcohol consumption and mental distress in a Norwegian population-based sample.
Publication Type: Academic Journal
Source(s): Psychiatry research [Psychiatry Res] 2022 Jan; Vol. 307, pp. 114257. Date of Electronic Publication: 2021 Nov 14.
Abstract: Little is known about genetic influences on the relationship between alcohol consumption and mental distress in the general population, where the majority report consumption and distress far below diagnostic thresholds. This study investigated single n...
Exome sequencing identifies genetic variants in anophthalmia and microphthalmia.
Publication Type: Academic Journal
Source(s): American journal of medical genetics. Part A [Am J Med Genet A] 2022 Aug; Vol. 188 (8), pp. 2376-2388. Date of Electronic Publication: 2022 Jun 18.
Abstract: Anophthalmia and microphthalmia (A/M) are rare birth defects affecting up to 2 per 10,000 live births. These conditions are manifested by the absence of an eye or reduced eye volumes within the orbit leading to vision loss. Although clinical case serie...
Multiplex MinION sequencing suggests enteric adenovirus F41 genetic diversity comparable to pre-COVID-19 era.
Publication Type: Academic Journal
Source(s): Microbial genomics [Microb Genom] 2023 Jan; Vol. 9 (1).
Abstract: Human adenovirus F41 causes acute gastroenteritis in children, and has recently been associated with an apparent increase in paediatric hepatitis of unknown aetiology in the UK, with further cases reported in multiple countries. Relatively little is kn...
Genetic Epidemiology of Complex Phenotypes.
Publication Type: Academic Journal
Source(s): Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2249, pp. 335-367.
Abstract: Genetic and environmental factors are critical elements in most common complex disease. Genetics is increasingly being recognized to play a substantive role in the susceptibility, prognosis, and treatment of common diseases. Due to recent and rapid adv...
The relative contributions of obesity, vitamin D, leptin, and adiponectin to multiple sclerosis risk: A Mendelian randomization mediation analysis.
Publication Type: Academic Journal
Source(s): Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2021 Nov; Vol. 27 (13), pp. 1994-2000. Date of Electronic Publication: 2021 Feb 19.
Abstract: Background: Obesity is associated with increased risk of multiple sclerosis (MS); however, the underlying mechanisms remain unclear.Objective: To determine the extent to which decreased vitamin D bioavailability and altered levels of adiponectin and le...