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Information encoded in gene-frequency trajectories.
Publication Type: Academic Journal
Source(s): Bio Systems [Biosystems] 2023 Sep; Vol. 231, pp. 104982. Date of Electronic Publication: 2023 Jul 23.
Abstract: In this work we present a systematic mathematical approximation scheme that exposes the way that information, about the evolutionary forces of selection and random genetic drift, is encoded within gene-frequency trajectories. We determine approximate, ...
Beyond fitness: the nature of selection acting through the constructive steps of lifecycles.
Publication Type: Academic Journal
Source(s): Evolution; international journal of organic evolution [Evolution] 2023 Sep 01; Vol. 77 (9), pp. 1967-1986.
Abstract: We address the problem of defining selection and extracting the adaptive part of evolutionary change, originally formalized by Fisher and Price. Conventionally, selection and adaptation are defined through fitness attributed to genes or genotypes chose...
An investigation of the sex-specific genetic architecture of fitness in Drosophila melanogaster.
Publication Type: Academic Journal
Source(s): Evolution; international journal of organic evolution [Evolution] 2023 Sep 01; Vol. 77 (9), pp. 2015-2028.
Abstract: In dioecious populations, the sexes employ divergent reproductive strategies to maximize fitness and, as a result, genetic variants can affect fitness differently in males and females. Moreover, recent studies have highlighted an important role of the ...
EyeG2P: an automated variant filtering approach improves efficiency of diagnostic genomic testing for inherited ophthalmic disorders.
Publication Type: Academic Journal
Source(s): Journal of medical genetics [J Med Genet] 2023 Aug; Vol. 60 (8), pp. 810-818. Date of Electronic Publication: 2023 Jan 20.
Abstract: Background: Genomic variant prioritisation is one of the most significant bottlenecks to mainstream genomic testing in healthcare. Tools to improve precision while ensuring high recall are critical to successful mainstream clinical genomic testing, in ...
Purging and accumulation of genetic load in conservation.
Publication Type: Academic Journal
Source(s): Trends in ecology & evolution [Trends Ecol Evol] 2023 Oct; Vol. 38 (10), pp. 961-969. Date of Electronic Publication: 2023 Jun 19.
Abstract: Our ability to assess the threat posed by the genetic load to small and declining populations has been greatly improved by advances in genome sequencing and computational approaches. Yet, considerable confusion remains around the definitions of the gen...
The genetic basis of epigenetic variation and its consequences for adaptation.
Publication Type: Academic Journal
Source(s): Current opinion in plant biology [Curr Opin Plant Biol] 2023 Oct; Vol. 75, pp. 102409. Date of Electronic Publication: 2023 Jul 12.
Abstract: Recent population genomic studies in plants have shed new light on natural epigenetic variation by identifying key genetic determinants, "trans modifiers," that influence epigenetic states genome-wide and their interplay with environmental factors. Her...
Inferring landscape resistance to gene flow when genetic drift is spatially heterogeneous.
Publication Type: Academic Journal
Source(s): Molecular ecology resources [Mol Ecol Resour] 2023 Oct; Vol. 23 (7), pp. 1574-1588. Date of Electronic Publication: 2023 Jun 18.
Abstract: In connectivity models, land cover types are assigned cost values characterizing their resistance to species movements. Landscape genetic methods infer these values from the relationship between genetic differentiation and cost distances. The spatial h...
Genetic variation and population structure of a widely distributed damselfly (Ischnura senegalensis).
Publication Type: Academic Journal
Source(s): Archives of insect biochemistry and physiology [Arch Insect Biochem Physiol] 2023 Oct; Vol. 114 (2), pp. 1-14. Date of Electronic Publication: 2023 Apr 09.
Abstract: Ischnura senegalensis Rambur, 1842 is among the most widespread damselfly species in the world. Unlike dragonflies with strong migration abilities, I. senegalensis have limited dispersing abilities. Gene flow among I. senegalensis populations may be gr...
Effect of recombination on genetic diversity of Caenorhabditis elegans.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2023 Sep 30; Vol. 13 (1), pp. 16425. Date of Electronic Publication: 2023 Sep 30.
Abstract: Greater molecular divergence and genetic diversity are present in regions of high recombination in many species. Studies describing the correlation between variant abundance and recombination rate have long focused on recombination in the context of li...
Enhanced frequency of transcription pre-initiation complexes assembly after exposure to UV irradiation results in increased repair activity and reduced probabilities for mutagenesis.
Publication Type: Academic Journal
Source(s): Nucleic acids research [Nucleic Acids Res] 2023 Sep 08; Vol. 51 (16), pp. 8575-8586.
Abstract: In addition to being essential for gene expression, transcription is crucial for the maintenance of genome integrity. Here, we undertook a systematic approach, to monitor the assembly kinetics of the pre-initiating RNA Polymerase (Pol) II at promoters ...