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 "Glutathione"
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The mammalian peroxisomal membrane is permeable to both GSH and GSSG - Implications for intraperoxisomal redox homeostasis.

Publication Type: Academic Journal

Source(s): Redox biology [Redox Biol] 2023 Jul; Vol. 63, pp. 102764. Date of Electronic Publication: 2023 May 25.

Abstract: Despite the large amounts of H 2 O 2 generated in mammalian peroxisomes, cysteine residues of intraperoxisomal proteins are maintained in a reduced state. The biochemistry behind this phenomenon remains unexplored, and simple questions such as "is the ...

Enzymology of reactive intermediate protection: kinetic analysis and temperature dependence of the mesophilic membrane protein catalyst MGST1.

Publication Type: Academic Journal

Source(s): The FEBS journal [FEBS J] 2023 Jul; Vol. 290 (13), pp. 3448-3460. Date of Electronic Publication: 2023 Mar 14.

Abstract: Glutathione transferases (GSTs) are a class of phase II detoxifying enzymes catalysing the conjugation of glutathione (GSH) to endogenous and exogenous electrophilic molecules, with microsomal glutathione transferase 1 (MGST1) being one of its key memb...

NO Is Not the Same as GSNO in the Regulation of Fe Deficiency Responses by Dicot Plants.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Aug 09; Vol. 24 (16). Date of Electronic Publication: 2023 Aug 09.

Abstract: Iron (Fe) is abundant in soils but with a poor availability for plants, especially in calcareous soils. To favor its acquisition, plants develop morphological and physiological responses, mainly in their roots, known as Fe deficiency responses. In dico...

A sensing platform for on-site detection of glutathione S-transferase using oxidized Pi@Ce-doped Zr-based metal-organic frameworks(MOFs).

Publication Type: Academic Journal

Source(s): Talanta [Talanta] 2023 Jul 01; Vol. 259, pp. 124537. Date of Electronic Publication: 2023 Apr 08.

Authors:

Abstract: The development of point-of-care testing (POCT) for glutathione S-transferase (GST) is an effective way to establish the mechanism of targeted monitoring of cancer chemotherapy drug metabolism. Assays for GST with high sensitivity as well as on-site sc...

Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4.

Publication Type: Academic Journal

Source(s): Redox biology [Redox Biol] 2023 Jul; Vol. 63, pp. 102719. Date of Electronic Publication: 2023 May 16.

Abstract: Selenoprotein glutathione peroxidases (GPX), like ubiquitously expressed GPX1 and the ferroptosis modulator GPX4, enact antioxidant activities by reducing hydroperoxides using glutathione. Overexpression of these enzymes is common in cancer and can be ...

Variation of the genes encoding antioxidant enzymes SOD2 (rs4880), GPX1 (rs1050450), and CAT (rs1001179) and susceptibility to male infertility: a genetic association study and in silico analysis.

Publication Type: Academic Journal

Source(s): Environmental science and pollution research international [Environ Sci Pollut Res Int] 2023 Aug; Vol. 30 (36), pp. 86412-86424. Date of Electronic Publication: 2023 Jul 05.

Abstract: Enzymatic factors including superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) are among the most important protective antioxidant systems in human semen. This study was conducted to investigate the association between the act...

Simultaneous determination of intracellular reduced and oxidized glutathiones by the König reaction.

Publication Type: Academic Journal

Source(s): Analytical methods : advancing methods and applications [Anal Methods] 2023 Jul 20; Vol. 15 (28), pp. 3426-3431. Date of Electronic Publication: 2023 Jul 20.

Abstract: The König reaction is commonly used for the detection of cyanide and its derivatives, including thiocyanate and selenocyanate. We found that this reaction can be used to quantify glutathione fluorometrically, and applied it to the simultaneous determin...

Engineered Salmonella inhibits GPX4 expression and induces ferroptosis to suppress glioma growth in vitro and in vivo.

Publication Type: Academic Journal

Source(s): Journal of neuro-oncology [J Neurooncol] 2023 Jul; Vol. 163 (3), pp. 607-622. Date of Electronic Publication: 2023 Jun 23.

Authors:

Abstract: Purpose: Glioma is a life-threatening malignancy where conventional therapies are ineffective. Bacterial cancer therapy has shown potential for glioma treatment, in particular, the facultative anaerobe Salmonella has been extensively studied. Meanwhile...

Redox perturbations in yeast cells lacking glutathione reductase.

Publication Type: Academic Journal

Source(s): Fungal genetics and biology : FG & B [Fungal Genet Biol] 2023 Jun; Vol. 167, pp. 103810. Date of Electronic Publication: 2023 May 10.

Abstract: Cellular redox homeostasis has a major effect on cell functions and its maintenance is supported by glutathione and protein thiols which serve as redox buffers in cells. The regulation of the glutathione biosynthetic pathway is a focus of a lot of scie...

Structure-Activity Relationship of Methyl 4-Aminobenzoate Derivatives as Being Drug Candidate Targeting Glutathione Related Enzymes: in Vitro and in Silico Approaches.

Publication Type: Academic Journal

Source(s): Chemistry & biodiversity [Chem Biodivers] 2023 May; Vol. 20 (5), pp. e202201220. Date of Electronic Publication: 2023 Apr 12.

Abstract: A thiol compound, glutathione, is essential for healthy cell defence against xenobiotics and oxidative stress. Glutathione reductase (GR) and glutathione S-transferase (GST) are two glutathione-related enzymes that function in the antioxidant and the d...

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