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Glyoxal fixation: An approach to solve immunohistochemical problem in neuroscience research.
Publication Type: Academic Journal
Source(s): Science advances [Sci Adv] 2023 Jul 14; Vol. 9 (28), pp. eadf7084. Date of Electronic Publication: 2023 Jul 14.
Abstract: The gold-standard fixative for immunohistochemistry is 4% formaldehyde; however, it limits antibody access to target molecules that are buried within specialized neuronal components, such as ionotropic receptors at the postsynapse and voltage-gated ion...
Comparison of Gas-Particle Partitioning of Glyoxal and Methylglyoxal in the Summertime Atmosphere at the Foot and Top of Mount Hua.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2023 Jul 07; Vol. 28 (13). Date of Electronic Publication: 2023 Jul 07.
Abstract: Glyoxal and methylglyoxal are important volatile organic compounds in the atmosphere. The gas-particle partitioning of these carbonyl compounds makes significant contributions to O 3 formation. In this study, both the gas- and particle-phase glyoxal an...
A fast and efficient method for the analysis of α-dicarbonyl compounds in aqueous solutions: Development and application.
Publication Type: Academic Journal
Source(s): Chemosphere [Chemosphere] 2023 Apr; Vol. 319, pp. 137977. Date of Electronic Publication: 2023 Feb 01.
Abstract: Among the highly oxygenated species formed in situ in the atmosphere, α-dicarbonyl compounds are the most reactive species, thus contributing to the formation of secondary organic aerosols that affect both air quality and climate. They are ubiquitous i...
Glyoxal-derived advanced glycation end-products, N ε -carboxymethyl-lysine, and glyoxal-derived lysine dimer induce apoptosis-related gene expression in hepatocytes.
Publication Type: Academic Journal
Source(s): Molecular biology reports [Mol Biol Rep] 2023 Mar; Vol. 50 (3), pp. 2511-2520. Date of Electronic Publication: 2023 Jan 06.
Abstract: Background: Advanced glycation end-products (AGEs) are proteins or lipids that have been glycated nonenzymatically by reducing sugars and their derivatives such as methylglyoxal. AGEs are known to cause inflammation, oxidative stress, and diseases in t...
Parkinsonism-Associated Protein DJ-1 Is an Antagonist, Not an Eraser, for Protein Glycation.
Publication Type: Academic Journal
Source(s): Biochemistry [Biochemistry] 2023 Mar 21; Vol. 62 (6), pp. 1181-1190. Date of Electronic Publication: 2023 Feb 23.
Abstract: Advanced glycation end-products (AGEs) are irreversible protein modifications that are strongly associated with aging and disease. Recently, the Parkinsonism-associated protein DJ-1 has been reported to exhibit deglycase activity that erases early glyc...
A freeze-substitution approach with solvent-based glyoxal fixative to prevent distortion of ocular structures.
Publication Type: Academic Journal
Source(s): Journal of histotechnology [J Histotechnol] 2022 Dec; Vol. 45 (4), pp. 172-181. Date of Electronic Publication: 2022 Sep 16.
Abstract: Investigating the function of delicate mammalian eyes often requires chemical fixation, histological sectioning, immunohistochemistry (IHC) and in situ hybridization (ISH). One of the long-standing challenges in the ocular histology field is the limite...
Experimental evidence for the elusive ketohydroperoxide pathway and the formation of glyoxal in ethylene ozonolysis.
Publication Type: Academic Journal
Source(s): Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Nov 24; Vol. 58 (94), pp. 13139-13142. Date of Electronic Publication: 2022 Nov 24.
Abstract: Despite decades of research on alkene ozonolysis, the kinetic network of the archetypal case of ethylene (CH 2 CH 2 ) with ozone (O 3 ) still lacks consensus. In this work, experimental evidence of an elusive diradical pathway is provided through the ...
Condensation of 4-Tert-butyl-2,6-dimethylbenzenesulfonamide with Glyoxal and Reaction Features: A New Process for Symmetric and Asymmetric Aromatic Sulfones.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2022 Nov 12; Vol. 27 (22). Date of Electronic Publication: 2022 Nov 12.
Abstract: The synthesis of substituted aza- and oxaazaisowurtzitanes via direct condensation is challenging. The selection of starting ammonia derivatives is very limited. The important step in developing alternative synthetic routes to these compounds is a deta...
Investigating the molecular mechanisms of glyoxal-induced cytotoxicity in human embryonic kidney cells: Insights from network toxicology and cell biology experiments.
Publication Type: Academic Journal
Source(s): Environmental toxicology [Environ Toxicol] 2022 Sep; Vol. 37 (9), pp. 2269-2280. Date of Electronic Publication: 2022 May 27.
Abstract: Glyoxal, a reactive carbonyl species, can be generated both endogenously (glucose metabolism) and exogenously (cigarette smoke and food system). Increasing evidence demonstrates that glyoxal exacerbates the development and progression of diabetic nephr...
Selected Maillard Reaction Products and Their Yeast Metabolites in Commercial Wines.
Publication Type: Academic Journal
Source(s): Journal of agricultural and food chemistry [J Agric Food Chem] 2023 Aug 16; Vol. 71 (32), pp. 12300-12310. Date of Electronic Publication: 2023 Aug 02.
Abstract: During beer and wine production, Maillard reaction products (MRPs) are formed, which have a particular influence on the taste and aroma of the fermented beverages. Compared to beer, less is known about individual Maillard compounds and especially corre...