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[Advances in heparin structural analysis by chromatography technologies].
Publication Type: Academic Journal
Source(s): Se pu = Chinese journal of chromatography [Se Pu] 2023 Feb; Vol. 41 (2), pp. 107-121.
Abstract: Heparin （Hp） is the most widely used anticoagulant drug in the clinics， with an annual global output of over 10 billion dollars. Hp， a member of the glycosaminoglycans （GAGs）， is prepared from porcine intestinal mucosa via extraction， separation， and p...
Anticoagulation Regimens in Pregnancy.
Publication Type: Academic Journal
Source(s): Obstetrics and gynecology clinics of North America [Obstet Gynecol Clin North Am] 2023 Mar; Vol. 50 (1), pp. 241-249.
Abstract: This article explores current recommendations for anticoagulation therapy in pregnancy, including antepartum, intrapartum, and postpartum guidelines. The authors review various screening strategies used to assess whether a patient is an appropriate can...
Potency Adjusted Blended Heparin of Bovine, Ovine, and Porcine Heparin Exhibit Comparable Biologic Effects to Referenced Single-Sourced Porcine Heparin.
Publication Type: Academic Journal
Source(s): Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis [Clin Appl Thromb Hemost] 2023 Jan-Dec; Vol. 29, pp. 10760296231163251.
Abstract: Introduction: Bovine and ovine mucosa represent alternate anticoagulants to porcine mucosa for production of unfractionated heparin (UFH). Standardized heparins from various sources can be blended and potency adjusted, blended heparins exhibit comparab...
Pharmacology of Heparin and Related Drugs: An Update.
Publication Type: Academic Journal
Source(s): Pharmacological reviews [Pharmacol Rev] 2023 Mar; Vol. 75 (2), pp. 328-379. Date of Electronic Publication: 2023 Feb 15.
Abstract: Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100 years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence, which potentiates the inhibitory action of antithrombin, a major inhibito...
Enzymatic Sequencing of Heparin Oligosaccharides Using Exolyase.
Publication Type: Academic Journal
Source(s): Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2619, pp. 249-256.
Abstract: Heparin/heparan sulfate (HP/HS) is a class of acidic polysaccharides with many potential medical applications, especially HP, and its derivatives, low molecular weight heparins (LMWHs), have been widely used as anticoagulants to treat thrombosis for de...
Application of anti-Xa assay in monitoring unfractionated heparin therapy in contemporary antithrombotic management.
Publication Type: Academic Journal
Source(s): Expert review of hematology [Expert Rev Hematol] 2023 Jan; Vol. 16 (1), pp. 1-8. Date of Electronic Publication: 2023 Jan 31.
Abstract: Introduction: Unfractionated heparin remains the most widely used agent in the prevention and acute treatment of thrombosis. Pharmacological complexities of this intriguing agent mandate frequent monitoring of its anticoagulant properties to maintain s...
Low Molecular Weight Heparin, Anti-inflammatory/Immunoregulatory and Antiviral Effects, a Short Update.
Publication Type: Academic Journal
Source(s): Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2023 Apr; Vol. 37 (2), pp. 277-281. Date of Electronic Publication: 2021 Aug 30.
Abstract: Low molecular weight heparin (LMWH) is a glycosaminoglycan long known for its anticoagulant properties. In recent times, recent evidence has associated this drug with extra pleiotropic anticoagulant effects that have also proven useful in the managemen...
Heparin Rebound: An In-Depth Review.
Publication Type: Academic Journal
Source(s): Journal of cardiothoracic and vascular anesthesia [J Cardiothorac Vasc Anesth] 2023 Apr; Vol. 37 (4), pp. 601-612. Date of Electronic Publication: 2022 Dec 24.
Abstract: The common conception of "heparin rebound" invokes heparin returning to circulation in the postoperative period after apparently adequate intraoperative reversal with protamine. This is believed to portend increased postoperative bleeding and provides ...