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Advanced Search Results For "HETEROGENEITY"

1 - 10 of 58,348 results for
 "HETEROGENEITY"
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Individual Genetic Heterogeneity.

Publication Type:Academic Journal

Source(s):Genes [Genes (Basel)] 2022 Sep 10; Vol. 13 (9). Date of Electronic Publication: 2022 Sep 10.

Abstract:Genetic variation has been widely covered in literature, however, not from the perspective of an individual in any species. Here, a synthesis of genetic concepts and variations relevant for individual genetic constitution is provided. All the different...

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Intratumor Heterogeneity and Antitumor Immunity Shape One Another Bidirectionally.

Publication Type:Academic Journal

Source(s):Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2022 Jul 15; Vol. 28 (14), pp. 2994-3001.

Abstract:Over the last decade, it has become clear that the genomic landscapes of tumors profoundly impact their immunogenicity and how tumor cells interact with immune cells. Whereas past discoveries mainly focused on the interplay between tumor immunogenicity...

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Comparative Genomics Revealed Wide Intra-Species Genetic Heterogeneity and Lineage-Specific Genes of Akkermansia muciniphila .

Publication Type:Academic Journal

Source(s):Microbiology spectrum [Microbiol Spectr] 2022 Jun 29; Vol. 10 (3), pp. e0243921. Date of Electronic Publication: 2022 May 10.

Abstract:Akkermansia muciniphila has potential as a next-generation probiotic, but few previous studies attempted to analyze its intraspecies population diversity. In this study, we performed a comparative genomic analysis of 112 filtered genomes from the NCBI ...

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DEPTH2: an mRNA-based algorithm to evaluate intratumor heterogeneity without reference to normal controls.

Publication Type:Academic Journal

Source(s):Journal of translational medicine [J Transl Med] 2022 Apr 01; Vol. 20 (1), pp. 150. Date of Electronic Publication: 2022 Apr 01.

Abstract:Background: Intratumor heterogeneity (ITH) is associated with tumor progression, unfavorable prognosis, immunosuppression, genomic instability, and therapeutic resistance. Thus, evaluation of ITH levels is valuable in cancer diagnosis and treatment.Met...

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A conditional autoregressive model for genetic association analysis accounting for genetic heterogeneity.

Publication Type:Academic Journal

Source(s):Statistics in medicine [Stat Med] 2022 Feb 10; Vol. 41 (3), pp. 517-542. Date of Electronic Publication: 2021 Nov 22.

Abstract:Converging evidence from genetic studies and population genetics theory suggest that complex diseases are characterized by remarkable genetic heterogeneity, and individual rare mutations with different effects could collectively play an important role ...

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Revealing the transcriptional heterogeneity of organ-specific metastasis in human gastric cancer using single-cell RNA Sequencing.

Publication Type:Academic Journal

Source(s):Clinical and translational medicine [Clin Transl Med] 2022 Feb; Vol. 12 (2), pp. e730.

Abstract:Background: Deciphering intra- and inter-tumoural heterogeneity is essential for understanding the biology of gastric cancer (GC) and its metastasis and identifying effective therapeutic targets. However, the characteristics of different organ-tropism ...

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Beyond Home Bias: International Portfolio Holdings and Information Heterogeneity.

Publication Type:Academic Journal

Source(s):Review of Financial Studies. Sep2022, Vol. 35 Issue 9, p4387-4422. 36p.

Abstract:We show that international portfolios reflect the underlying heterogeneity in investors' beliefs. Using data on the foreign sovereign debt holdings of European banks matched with their forecasts on future bond yields, we find that expecting higher retu...

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Widespread genetic heterogeneity of human ribosomal RNA genes.

Publication Type:Academic Journal

Source(s):RNA (New York, N.Y.) [RNA] 2022 Apr; Vol. 28 (4), pp. 478-492. Date of Electronic Publication: 2022 Feb 02.

Abstract:Polymorphism drives survival under stress and provides adaptability. Genetic polymorphism of ribosomal RNA (rRNA) genes derives from internal repeat variation of this multicopy gene, and from interindividual variation. A considerable amount of rRNA seq...

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Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression.

Publication Type:Academic Journal

Source(s):Oncogene [Oncogene] 2022 Mar; Vol. 41 (13), pp. 1835-1850. Date of Electronic Publication: 2022 Feb 10.

Abstract:Analyzing different tumor regions by next generation sequencing allows the assessment of intratumor genetic heterogeneity (ITGH), a phenomenon that has been studied widely in some tumor types but has been less well explored in endometrial carcinoma (EC...

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Clinical and genetic heterogeneity of HNF4A/HNF1A mutations in a multicentre paediatric cohort with hyperinsulinaemic hypoglycaemia.

Publication Type:Academic Journal

Source(s):European journal of endocrinology [Eur J Endocrinol] 2022 Feb 22; Vol. 186 (4), pp. 417-427. Date of Electronic Publication: 2022 Feb 22.

Abstract:Objective: The phenotype mediated by HNF4A/HNF1A mutations is variable and includes diazoxide-responsive hyperinsulinaemic hypoglycaemia (HH) and maturity-onset diabetes of the young (MODY).Design: We characterised an international multicentre paediatr...

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