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Advanced Search Results For "HIV-1"

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 "HIV-1"
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Enhanced Transcriptional Strength of HIV-1 Subtype C Minimizes Gene Expression Noise and Confers Stability to the Viral Latent State.

Publication Type: Academic Journal

Source(s): Journal of virology [J Virol] 2023 Jan 31; Vol. 97 (1), pp. e0137622. Date of Electronic Publication: 2022 Dec 19.

Abstract: Stochastic fluctuations in gene expression emanating from the HIV-1 long terminal repeat (LTR), amplified by the Tat positive feedback circuit, determine the choice between viral infection fates: active transcription (ON) or transcriptional silence (OF...

Structural Insights into the Mechanism of HIV-1 Tat Secretion from the Plasma Membrane.

Publication Type: Academic Journal

Source(s): Journal of molecular biology [J Mol Biol] 2023 Jan 30; Vol. 435 (2), pp. 167880. Date of Electronic Publication: 2022 Nov 10.

Abstract: Human immunodeficiency virus type 1 (HIV-1) trans-activator of transcription (Tat) is a small, intrinsically disordered basic protein that plays diverse roles in the HIV-1 replication cycle, including promotion of efficient viral RNA transcription. Tat...

New antiretroviral inhibitors and HIV-1 drug resistance: more focus on 90% HIV-1 isolates?

Publication Type: Academic Journal

Source(s): FEMS microbiology reviews [FEMS Microbiol Rev] 2023 Jan 16; Vol. 47 (1).

Abstract: Combined HIV antiretroviral therapy (cART) has been effective except if drug resistance emerges. As cART has been rolled out in low-income countries, drug resistance has emerged at higher rates than observed in high income countries due to factors incl...

Identification of 5' upstream sequence involved in HSPBP1 gene transcription and its downregulation during HIV-1 infection.

Publication Type: Academic Journal

Source(s): Virus research [Virus Res] 2023 Jan 15; Vol. 324, pp. 199034. Date of Electronic Publication: 2022 Dec 26.

Abstract: The Human Immunodeficiency Virus-1 (HIV-1) is known to modulate the host environment for successful replication and propagation like other viruses. The virus utilises its proteins to interact with or modulate host factors and host signalling pathways t...

Association of human cytomegalovirus in urine with end-organ diseases in stage 2/3 HIV-1-infected individuals.

Publication Type: Academic Journal

Source(s): Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2023 Jan; Vol. 158, pp. 105351. Date of Electronic Publication: 2022 Dec 11.

Authors:

Abstract: Background: Human cytomegalovirus (HCMV) is prevalent in human immunodeficiency virus type 1 (HIV-1)-infected individuals but is suppressed by the host immune system bolstered by antiretroviral therapy. During stage 4 of HIV-1 infection, HCMV becomes a...

New insights into transcription elongation control of HIV-1 latency and rebound.

Publication Type: Academic Journal

Source(s): Trends in immunology [Trends Immunol] 2023 Jan; Vol. 44 (1), pp. 60-71. Date of Electronic Publication: 2022 Dec 08.

Abstract: Antiretroviral therapy reduces circulating HIV-1 to undetectable amounts but does not eliminate the virus due to the persistence of a stable reservoir of latently infected cells. The reservoir is maintained both by proliferation of latently infected ce...

HIV-1 gp120-CXCR4 recognition probed with synthetic nanomolar affinity D-peptides containing fragments of gp120 V3 loop.

Publication Type: Academic Journal

Source(s): European journal of medicinal chemistry [Eur J Med Chem] 2022 Dec 15; Vol. 244, pp. 114797. Date of Electronic Publication: 2022 Sep 28.

Authors:

Abstract: The human immunodeficiency virus type 1 (HIV-1) recognizes one of its principal coreceptors, the CXC chemokine receptor 4 (CXCR4) on the host cell via the third variable loop (V3 loop) of HIV-1 envelope glycoprotein gp120 during the viral entry process...

Different dendritic cells-based vaccine constructs influence HIV-1 antigen-specific immunological responses and cytokine generation in virion-exposed splenocytes.

Publication Type: Academic Journal

Source(s): International immunopharmacology [Int Immunopharmacol] 2022 Dec; Vol. 113 (Pt A), pp. 109406. Date of Electronic Publication: 2022 Nov 08.

Abstract: In recent years, dendritic cells (DCs)-based vaccines have been developed to combat HIV-1 infection in preclinical and clinical trials. In this study, mice bone marrow cells-derived DCs were pulsed with the recombinant Nef, heat shock protein 27 (Hsp27...

Characterization of a novel HIV-1 circulating recombinant form, CRF91_cpx, comprising CRF02_AG, G, J, and U, mostly among men who have sex with men.

Publication Type: Academic Journal

Source(s): Virulence [Virulence] 2022 Dec; Vol. 13 (1), pp. 1331-1348.

Abstract: Prospective molecular studies of HIV-1 pol region (2253-5250 in HXB2 genome) sequences from sequenced samples of 269 HIV-1-infected patients in Cyprus (2017-2021) revealed a transmission cluster of 14 unknown HIV-1 recombinants that were not classified...

Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4 + T cells.

Publication Type: Academic Journal

Source(s): Emerging microbes & infections [Emerg Microbes Infect] 2022 Dec; Vol. 11 (1), pp. 391-405.

Authors:

Abstract: ABSTRACT HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the "Shock and Kill" strategy to mobilize the latently infected cells to be susceptible for clearance b...

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