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Gene Expression Profiling in Coeliac Disease Confirmed the Key Role of the Immune System and Revealed a Molecular Overlap with Non-Celiac Gluten Sensitivity.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Apr 24; Vol. 24 (9). Date of Electronic Publication: 2023 Apr 24.
Abstract: Coeliac disease (CeD) is an immune-mediated disorder triggered by the ingestion of gluten and an as yet unidentified environmental factor in genetically predisposed individuals. The disease involves a major autoimmune component that primarily damages t...
Opportunities for Treg cell therapy for the treatment of human disease.
Publication Type: Academic Journal
Source(s): Frontiers in immunology [Front Immunol] 2023 Apr 19; Vol. 14, pp. 1166135. Date of Electronic Publication: 2023 Apr 19 (Print Publication: 2023).
Abstract: Regulatory T (Treg) cells are essential for maintaining peripheral tolerance, preventing autoimmunity, and limiting chronic inflammatory diseases. This small CD4+ T cell population can develop in the thymus and in the peripheral tissues of the immune s...
Transforming the understanding of brain immunity.
Publication Type: Academic Journal
Source(s): Science (New York, N.Y.) [Science] 2023 Apr 07; Vol. 380 (6640), pp. eabo7649. Date of Electronic Publication: 2023 Apr 07.
Abstract: Contemporary studies have completely changed the view of brain immunity from envisioning the brain as isolated and inaccessible to peripheral immune cells to an organ in close physical and functional communication with the immune system for its mainten...
Selenium metabolism and regulation of immune cells in immune-associated diseases.
Publication Type: Academic Journal
Source(s): Journal of cellular physiology [J Cell Physiol] 2022 Sep; Vol. 237 (9), pp. 3449-3464. Date of Electronic Publication: 2022 Jul 05.
Abstract: Selenium, as one of the essential microelements, plays an irreplaceable role in metabolism regulation and cell survival. Selenium metabolism and regulation have great effects on physiological systems especially the immune system. Therefore, selenium is...
Do peripheral neuropathies differ among immune checkpoint inhibitors? Reports from the European post-marketing surveillance database in the past 10 years.
Publication Type: Academic Journal
Source(s): Frontiers in immunology [Front Immunol] 2023 Mar 16; Vol. 14, pp. 1134436. Date of Electronic Publication: 2023 Mar 16 (Print Publication: 2023).
Abstract: Although the immunotherapy advent has revolutionized cancer treatment, it, unfortunately, does not spare cancer patients from possible immune-related adverse events (irAEs), which can also involve the peripheral nervous system. Immune checkpoint inhibi...
Autoantibody profiles in patients with immune checkpoint inhibitor-induced neurological immune related adverse events.
Publication Type: Academic Journal
Source(s): Frontiers in immunology [Front Immunol] 2023 Feb 08; Vol. 14, pp. 1108116. Date of Electronic Publication: 2023 Feb 08 (Print Publication: 2023).
Abstract: Background: Neurological immune-related adverse events (irAE-n) are severe and potentially fatal toxicities of immune checkpoint inhibitors (ICI). To date, the clinical significance of neuronal autoantibodies in irAE-n is poorly understood. Here, we ch...
Immune-mediated diseases involving central and peripheral nervous systems.
Publication Type: Academic Journal
Source(s): European journal of neurology [Eur J Neurol] 2023 Feb; Vol. 30 (2), pp. 490-500. Date of Electronic Publication: 2022 Nov 27.
Abstract: Background and Purpose: In addition to combined central and peripheral demyelination, other immune diseases could involve both the central nervous system (CNS) and peripheral nervous system (PNS).Methods: To identify immune-mediated diseases responsibl...
Blood cell counts can predict adverse events of immune checkpoint inhibitors: A systematic review and meta-analysis.
Publication Type: Report
Source(s): Frontiers in immunology [Front Immunol] 2023 Mar 07; Vol. 14, pp. 1117447. Date of Electronic Publication: 2023 Mar 07 (Print Publication: 2023).
Abstract: Background: Cancer is concerning owing to its high mortality rate. Consequently, methods of prolonging the life of patients with cancer have become the primary focus of attention research. In recent years, immune checkpoint inhibitors (ICIs) have achie...
Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors.
Publication Type: Academic Journal
Source(s): Med (New York, N.Y.) [Med] 2023 Feb 10; Vol. 4 (2), pp. 113-129.e7. Date of Electronic Publication: 2023 Jan 23.
Abstract: Background: Immune checkpoint inhibitors (ICIs) are among the most promising treatment options for melanoma and non-small cell lung cancer (NSCLC). While ICIs can induce effective anti-tumor responses, they may also drive serious immune-related adverse...
LNCing RNA to immunity.
Publication Type: Academic Journal
Source(s): Trends in immunology [Trends Immunol] 2022 Jun; Vol. 43 (6), pp. 478-495. Date of Electronic Publication: 2022 Apr 29.
Abstract: Despite an ever-increasing appreciation of how protein-coding genes shape immune responses, the molecular underpinnings of immune regulation remain incompletely understood. This incomplete picture impedes the development of more precise therapeutics an...