scroll to top
0

EBSCO Auth Banner

Let's find your institution. Click here.

Advanced Search Results For "IMMUNOGLOBULINS"

1 - 10 of 533,602 results for
 "IMMUNOGLOBULINS"
Results per page:

Immunoglobulins genes in Neoceratodus forsteri and Protopterus annectens explain the origin of the immunoglobulins of the animals that passed ashore.

Publication Type: Academic Journal

Source(s): Molecular immunology [Mol Immunol] 2022 Dec; Vol. 152, pp. 97-105. Date of Electronic Publication: 2022 Oct 26.

Abstract: Sarcopterygian fishes are a taxon of bony fishes. They include lungfish and coelacanths (six species of lungfish and two species of coelacanths). Evolutionary adaptations arose with these fish, such as the appearance of lungs and paired lobed fins that...

View details

Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer.

Publication Type: Academic Journal

Source(s): Nature communications [Nat Commun] 2022 Oct 23; Vol. 13 (1), pp. 6314. Date of Electronic Publication: 2022 Oct 23.

Abstract: Immunoglobulin M (IgM) is the most ancient of the five isotypes of immunoglobulin (Ig) molecules and serves as the first line of defence against pathogens. Here, we use cryo-EM to image the structure of the human full-length IgM pentamer, revealing ant...

View details

XLID syndrome gene Med12 promotes Ig isotype switching through chromatin modification and enhancer RNA regulation.

Publication Type: Academic Journal

Source(s): Science advances [Sci Adv] 2022 Nov 25; Vol. 8 (47), pp. eadd1466. Date of Electronic Publication: 2022 Nov 25.

Abstract: The transcriptional coactivator Med12 regulates gene expression through its kinase module. Here, we show a kinase module-independent function of Med12 in CSR. Med12 is essential for super-enhancer activation by collaborating with p300-Jmjd6/Carm1 coact...

View details

Isotypic analysis of anti-p53 serum autoantibodies and p53 protein tissue phenotypes in colorectal cancer.

Publication Type: Academic Journal

Source(s): Human pathology [Hum Pathol] 2022 Oct; Vol. 128, pp. 1-10. Date of Electronic Publication: 2022 Jun 22.

Abstract: The presence of IgA- and IgM-specific autoantibody (AAb) isotypes and their relationship to p53 tissue expression patterns are not well understood. This study aims to investigate the clinical utility of the anti-p53 AAb isotypes and tissue positivity i...

View details

E6020, a TLR4 Agonist Adjuvant, Enhances Both Antibody Titers and Isotype Switching in Response to Immunization with Hapten-Protein Antigens and Is Diminished in Mice with TLR4 Signaling Insufficiency.

Publication Type: Academic Journal

Source(s): Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Nov 15; Vol. 209 (10), pp. 1950-1959.

Abstract: The mechanisms by which TLR4-based adjuvants enhance immunogenicity are not fully understood. We have taken advantage of a novel knock-in mouse strain that homozygously expresses two single-nucleotide polymorphisms (SNPs) that are homologous to human T...

View details

Immunoglobulin heavy constant gamma gene evolution is modulated by both the divergent and birth-and-death evolutionary models.

Publication Type: Academic Journal

Source(s): Primates; journal of primatology [Primates] 2022 Nov; Vol. 63 (6), pp. 611-625. Date of Electronic Publication: 2022 Sep 16.

Abstract: Immunoglobulin G (IgG) is one of the five antibody classes produced in mammals as part of the humoral responses accountable for protecting the organisms from infection. Its antibody heavy chain constant region is encoded by the Ig heavy-chain gamma gen...

View details

Prognostic significance of NY-ESO-1 antigen and PIGR expression in esophageal tumors of CHP-NY-ESO-1-vaccinated patients as adjuvant therapy.

Publication Type: Academic Journal

Source(s): Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2022 Nov; Vol. 71 (11), pp. 2743-2755. Date of Electronic Publication: 2022 Apr 16.

Abstract: The aim of this study was to determine the efficacy and the biomarkers of the CHP-NY-ESO-1 vaccine complexed with full-length NY-ESO-1 protein and a cholesteryl pullulan (CHP) in patients with esophageal squamous cell carcinoma (ESCC) after surgery. We...

View details

Notch effector recombination signal binding protein for immunoglobulin kappa J signaling is required for the initiation of endometrial stromal cell decidualization†.

Publication Type: Academic Journal

Source(s): Biology of reproduction [Biol Reprod] 2022 Oct 11; Vol. 107 (4), pp. 977-983.

Abstract: The Notch signaling pathway is required for reproductive success. This pathway activates its transcriptional effector, recombination signal binding protein for immunoglobulin kappa J (Rbpj), to induce transcription of its target genes. This signaling p...

View details

IgG4-related sialadenitis - a rare bilateral submandibular gland enlargement: case report.

Publication Type: Academic Journal

Source(s): Oral and maxillofacial surgery [Oral Maxillofac Surg] 2022 Dec; Vol. 26 (4), pp. 673-677. Date of Electronic Publication: 2022 Jan 14.

Abstract: Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory condition of unknown etiology. Although the salivary glands are currently considered among the most commonly affected among them, oral and maxillofacial surgeons are generally not famil...

View details

Dupilumab as an adjunct treatment for a patient with steroid-dependent immunoglobulin G4-related disease complicated by asthma: a case report.

Publication Type: Academic Journal

Source(s): The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 2022 Dec; Vol. 59 (12), pp. 2395-2401. Date of Electronic Publication: 2021 Dec 31.

Abstract: Introduction : Immunoglobulin G4-related disease (IgG4-RD) responds well to glucocorticoids but is often associated with relapses. Interleukin (IL)-4 and IL-13 are involved in the pathogenesis of IgG4-RD. We present the first case in which dupilumab wa...

View details
sponsored