Advanced Search Results For "IMMUNOLOGY"
Your filters
HIV-1 DNA and Immune Activation Levels Differ for Long-Lived T-Cells in Lymph Nodes, Compared with Peripheral Blood, during Antiretroviral Therapy.
Publication Type: Academic Journal
Source(s): Journal of virology [J Virol] 2023 Apr 27; Vol. 97 (4), pp. e0167022. Date of Electronic Publication: 2023 Mar 27.
Abstract: Elucidating the mechanisms underlying the persistence and location of the HIV reservoir is critical for developing cure interventions. While it has been shown that levels of T-cell activation and the size of the HIV reservoir are greater in rectal tiss...
Linker histone H1 modulates defense priming and immunity in plants.
Publication Type: Academic Journal
Source(s): Nucleic acids research [Nucleic Acids Res] 2023 May 22; Vol. 51 (9), pp. 4252-4265.
Abstract: Linker H1 histones play an important role in animal and human pathogenesis, but their function in plant immunity is poorly understood. Here, we analyzed mutants of the three canonical variants of Arabidopsis H1 histones, namely H1.1, H1.2 and H1.3. We ...
Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma.
Publication Type: Academic Journal
Source(s): Nature [Nature] 2023 May; Vol. 617 (7962), pp. 807-817. Date of Electronic Publication: 2023 May 17.
Abstract: Microbial organisms have key roles in numerous physiological processes in the human body and have recently been shown to modify the response to immune checkpoint inhibitors 1,2 . Here we aim to address the role of microbial organisms and their potentia...
Endothelial Rap1B mediates T-cell exclusion to promote tumor growth: a novel mechanism underlying vascular immunosuppression.
Publication Type: Academic Journal
Source(s): Angiogenesis [Angiogenesis] 2023 May; Vol. 26 (2), pp. 265-278. Date of Electronic Publication: 2022 Nov 20.
Abstract: Overcoming vascular immunosuppression: lack of endothelial cell (EC) responsiveness to inflammatory stimuli in the proangiogenic environment of tumors, is essential for successful cancer immunotherapy. The mechanisms through which Vascular Endothelial ...
SARS-CoV-2 Omicron boosting induces de novo B cell response in humans.
Publication Type: Academic Journal
Source(s): Nature [Nature] 2023 May; Vol. 617 (7961), pp. 592-598. Date of Electronic Publication: 2023 Apr 03.
Abstract: The primary two-dose SARS-CoV-2 mRNA vaccine series are strongly immunogenic in humans, but the emergence of highly infectious variants necessitated additional doses and the development of vaccines aimed at the new variants 1-4 . SARS-CoV-2 booster imm...
Genomic investigations of unexplained acute hepatitis in children.
Publication Type: Academic Journal
Source(s): Nature [Nature] 2023 May; Vol. 617 (7961), pp. 564-573. Date of Electronic Publication: 2023 Mar 30.
Abstract: Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK 1 . Here we report an investigation of 38 cases, 66 age-matched immunocompetent con...
The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination.
Publication Type: Academic Journal
Source(s): British journal of cancer [Br J Cancer] 2023 May; Vol. 128 (9), pp. 1777-1787. Date of Electronic Publication: 2023 Feb 23.
Abstract: Background: The immune peptidome of OPSCC has not previously been studied. Cancer-antigen specific vaccination may improve clinical outcome and efficacy of immune checkpoint inhibitors such as PD1/PD-L1 antibodies.Methods: Mapping of the OPSCC HLA liga...
Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy.
Publication Type: Academic Journal
Source(s): Angiogenesis [Angiogenesis] 2023 May; Vol. 26 (2), pp. 279-293. Date of Electronic Publication: 2022 Dec 02.
Abstract: Purpose: Ongoing angiogenesis renders the tumor endothelium unresponsive to inflammatory cytokines and interferes with adhesion of leukocytes, resulting in escape from immunity. This process is referred to as tumor endothelial cell anergy. We aimed to ...
Characterization of the Impact of Merkel Cell Polyomavirus-Induced Interferon Signaling on Viral Infection.
Publication Type: Academic Journal
Source(s): Journal of virology [J Virol] 2023 Apr 27; Vol. 97 (4), pp. e0190722. Date of Electronic Publication: 2023 Mar 22.
Abstract: Merkel cell polyomavirus (MCPyV) has been associated with approximately 80% of Merkel cell carcinoma (MCC), an aggressive and increasingly incident skin cancer. The link between host innate immunity, viral load control, and carcinogenesis has been esta...
PSMB4 Degrades the Porcine Reproductive and Respiratory Syndrome Virus Nsp1α Protein via the Autolysosome Pathway and Induces the Production of Type I Interferon.
Publication Type: Academic Journal
Source(s): Journal of virology [J Virol] 2023 Apr 27; Vol. 97 (4), pp. e0026423. Date of Electronic Publication: 2023 Mar 21.
Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) causes respiratory disease in pigs of all ages and reproductive failure in sows, resulting in great economic losses to the swine industry. In this work, we identified the interaction between P...