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Advanced Search Results For "IMPORTS"

1 - 10 of 148,631 results for
 "IMPORTS"
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Towards a molecular mechanism underlying mitochondrial protein import through the TOM and TIM23 complexes.

Publication Type:Academic Journal

Source(s):ELife [Elife] 2022 Jun 08; Vol. 11. Date of Electronic Publication: 2022 Jun 08.

Abstract:Nearly all mitochondrial proteins need to be targeted for import from the cytosol. For the majority, the first port of call is the translocase of the outer membrane (TOM complex), followed by a procession of alternative molecular machines, conducting t...

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Stress Responses Elicited by Misfolded Proteins Targeted to Mitochondria.

Publication Type:Academic Journal

Source(s):Journal of molecular biology [J Mol Biol] 2022 Jun 30; Vol. 434 (12), pp. 167618. Date of Electronic Publication: 2022 Apr 30.

Abstract:The double-membrane-bound architecture of mitochondria, essential for ATP production, sub-divides the organelle into inter-membrane space (IMS) and matrix. IMS and matrix possess contrasting oxido-reductive environments and discrete protein quality con...

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Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors.

Publication Type:Academic Journal

Source(s):Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jun 28; Vol. 119 (26), pp. e2200158119. Date of Electronic Publication: 2022 Jun 22.

Abstract:Mitochondrial preproteins synthesized in cytosol are imported into mitochondria by a multisubunit translocase of the outer membrane (TOM) complex. Functioned as the receptor, the TOM complex components, Tom 20, Tom22, and Tom70, recognize the presequen...

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Coupling to Pam16 differentially controls the dual role of Pam18 in protein import and respiratory chain formation.

Publication Type:Academic Journal

Source(s):Cell reports [Cell Rep] 2022 Apr 05; Vol. 39 (1), pp. 110619.

Abstract:The presequence translocase (TIM23 complex) imports precursor proteins into the mitochondrial inner membrane and matrix. The presequence translocase-associated motor (PAM) provides a driving force for transport into the matrix. The J-protein Pam18 stim...

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Multiple variants of the human presequence translocase motor subunit Magmas govern the mitochondrial import.

Publication Type:Academic Journal

Source(s):The Journal of biological chemistry [J Biol Chem] 2021 Dec; Vol. 297 (6), pp. 101349. Date of Electronic Publication: 2021 Oct 29.

Abstract:Mitochondrial protein translocation is an intricately regulated process that requires dedicated translocases at the outer and inner membranes. The presequence translocase complex, translocase of the inner membrane 23, facilitates most of the import of ...

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Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex.

Publication Type:Academic Journal

Source(s):Molecular cell [Mol Cell] 2022 Jan 06; Vol. 82 (1), pp. 44-59.e6. Date of Electronic Publication: 2021 Dec 06.

Abstract:Mutations in PINK1 cause autosomal-recessive Parkinson's disease. Mitochondrial damage results in PINK1 import arrest on the translocase of the outer mitochondrial membrane (TOM) complex, resulting in the activation of its ubiquitin kinase activity by ...

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Genetic Variants and Haplotypes of TOMM40, APOE, and APOC1 are Related to the Age of Onset of Late-onset Alzheimer Disease in a Colombian Population.

Publication Type:Academic Journal

Source(s):Alzheimer disease and associated disorders [Alzheimer Dis Assoc Disord] 2022 Jan-Mar 01; Vol. 36 (1), pp. 29-35.

Abstract:Background: The Apolipoprotein E (APOE) gene is the main risk factor for late-onset Alzheimer disease (LOAD). Genetic variants and haplotypes in regions near the APOE locus may be associated with LOAD in the Colombian population.Objective: We evaluated...

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Architecture and assembly dynamics of the essential mitochondrial chaperone complex TIM9·10·12.

Publication Type:Academic Journal

Source(s):Structure (London, England : 1993) [Structure] 2021 Sep 02; Vol. 29 (9), pp. 1065-1073.e4. Date of Electronic Publication: 2021 May 10.

Abstract:Tim chaperones transport membrane proteins to the two mitochondrial membranes. TIM9·10, a 70 kDa protein complex formed by 3 copies of Tim9 and Tim10, guides its clients across the aqueous compartment. The TIM9·10·12 complex is the anchor point at the ...

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Identification and analysis of deletion breakpoints in four Mohr-Tranebjærg syndrome (MTS) patients.

Publication Type:Academic Journal

Source(s):Scientific reports [Sci Rep] 2022 Sep 02; Vol. 12 (1), pp. 14959. Date of Electronic Publication: 2022 Sep 02.

Abstract:Mohr-Tranebjærg syndrome is an X-linked syndrome characterized by sensorineural hearing impairment in childhood, followed by progressive neurodegeneration leading to a broad phenotypic spectrum. Genetically MTS is caused by pathogenic variants in the T...

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AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5.

Publication Type:Academic Journal

Source(s):The EMBO journal [EMBO J] 2022 Sep 01; Vol. 41 (17), pp. e110784. Date of Electronic Publication: 2022 Jul 20.

Abstract:The mitochondrial intermembrane space protein AIFM1 has been reported to mediate the import of MIA40/CHCHD4, which forms the import receptor in the mitochondrial disulfide relay. Here, we demonstrate that AIFM1 and MIA40/CHCHD4 cooperate beyond this MI...

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