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Advanced Search Results For "INSULIN"

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 "INSULIN"
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Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling.

Publication Type: Academic Journal

Source(s): The Journal of clinical investigation [J Clin Invest] 2023 Feb 15; Vol. 133 (4). Date of Electronic Publication: 2023 Feb 15.

Abstract: Insulin and IGF-1 receptors (IR and IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR primarily regulating metabolic homeostasis and IGF1R regulating mitogenic control and growth. Here, ...

Evaluation of Insulin Lispro Pharmacokinetics and Pharmacodynamics Over 10 Days of Continuous Insulin Infusion in People With Type 1 Diabetes.

Publication Type: Academic Journal

Source(s): Journal of diabetes science and technology [J Diabetes Sci Technol] 2023 Mar; Vol. 17 (2), pp. 274-282. Date of Electronic Publication: 2022 Dec 28.

Abstract: Background: We evaluated the effect of meloxicam on insulin lispro pharmacokinetics and glucose pharmacodynamics over 10 days of continuous subcutaneous insulin infusion (CSII) at one infusion site in people with type 1 diabetes (T1D).Method: This phas...

Sleeve Gastrectomy-Induced Weight Loss Increases Insulin Clearance in Obese Mice.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jan 15; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 15.

Abstract: Sleeve gastrectomy (SG) successfully recovers metabolic homeostasis in obese humans and rodents while also resulting in the normalization of insulin sensitivity and insulinemia. Reduced insulin levels have been attributed to lower insulin secretion and...

Suppression of Insulin Receptor Substrate 1 Inhibits Breast Cancer Growth In Vitro and in Female Athymic Mice.

Publication Type: Academic Journal

Source(s): Endocrinology [Endocrinology] 2023 Jan 09; Vol. 164 (3).

Authors:

Abstract: Targeting the type I insulin-like growth factor receptor (IGF-IR) has not been successful in breast cancer. Data suggest the highly homologous insulin receptor (IR) may be an alternate growth stimulatory pathway used by cancer cells. Since both recepto...

Cerebrovascular insulin receptors are defective in Alzheimer's disease.

Publication Type: Academic Journal

Source(s): Brain : a journal of neurology [Brain] 2023 Jan 05; Vol. 146 (1), pp. 75-90.

Abstract: Central response to insulin is suspected to be defective in Alzheimer's disease. As most insulin is secreted in the bloodstream by the pancreas, its capacity to regulate brain functions must, at least partly, be mediated through the cerebral vasculatur...

Arctigenin mitigates insulin resistance by modulating the IRS2/GLUT4 pathway via TLR4 in type 2 diabetes mellitus mice.

Publication Type: Academic Journal

Source(s): International immunopharmacology [Int Immunopharmacol] 2023 Jan; Vol. 114, pp. 109529. Date of Electronic Publication: 2022 Dec 06.

Authors:

Abstract: Arctigenin (AR), extracted from Arctium lappa L. (Burdock), is a folk herbal medicine used to treat diabetes. However, its mechanism of action has remained elusive. In this study, type 2 diabetes mellitus (T2DM) mice received AR orally for 10 weeks to ...

Hybrid Closed-Loop Control with Ultrarapid Lispro Compared with Standard Insulin Aspart and Faster Insulin Aspart: An In Silico Study.

Publication Type: Academic Journal

Source(s): Journal of diabetes science and technology [J Diabetes Sci Technol] 2023 Jan; Vol. 17 (1), pp. 176-185. Date of Electronic Publication: 2021 Oct 17.

Abstract: Objective: There is room for improvement in the performance of closed-loop regulation algorithms during the prandial period. This in silico study evaluated the efficiency and safety of ultrarapid lispro insulin using the Diabeloop DBLG1® algorithm.Meth...

Isolation of a novel missense mutation in insulin receptor as a spontaneous revertant in ImpL2 mutants in Drosophila.

Publication Type: Academic Journal

Source(s): Development (Cambridge, England) [Development] 2023 Jan 01; Vol. 150 (1). Date of Electronic Publication: 2023 Jan 06.

Abstract: Evolutionarily conserved insulin/insulin-like growth factor (IGF) signaling (IIS) correlates nutrient levels to metabolism and growth, thereby playing crucial roles in development and adult fitness. In the fruit fly Drosophila, ImpL2, an ortholog of IG...

Ferulic acid enhances insulin secretion by potentiating L-type Ca 2+ channel activation.

Publication Type: Academic Journal

Source(s): Journal of integrative medicine [J Integr Med] 2023 Jan; Vol. 21 (1), pp. 99-105. Date of Electronic Publication: 2022 Nov 23.

Abstract: Objective: To investigate the effect of ferulic acid, a natural compound, on pancreatic beta cell viability, Ca 2+ channels, and insulin secretion.Methods: We studied the effects of ferulic acid on rat insulinoma cell line viability using the 3-(4,5-di...

Interleukin-4 reduces insulin secretion in human islets from healthy but not type-2 diabetic donors.

Publication Type: Academic Journal

Source(s): Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Mar 15; Vol. 649, pp. 87-92. Date of Electronic Publication: 2023 Jan 30.

Abstract: Type 2 diabetes (T2D) is associated with low-grade inflammation. Here we investigate if the anti-inflammatory cytokine interleukin-4 (IL-4) affects glucose-stimulated insulin secretion (GSIS) in human islets from non-diabetic (ND) and type-2 diabetic (...

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