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Autoantibodies Neutralizing Type III Interferons Are Uncommon in Patients with Severe Coronavirus Disease 2019 Pneumonia.
Publication Type: Academic Journal
Source(s): Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2023 Sep; Vol. 43 (9), pp. 379-393. Date of Electronic Publication: 2023 May 29.
Abstract: Autoantibodies (AABs) neutralizing type I interferons (IFN) underlie about 15% of cases of critical coronavirus disease 2019 (COVID-19) pneumonia. The impact of autoimmunity toward type III IFNs remains unexplored. We included samples from 1,002 patien...
Characterization of Monoclonal Antibodies to Measure Cell Surface Protein Levels of Human Interferon-Lambda Receptor 1.
Publication Type: Academic Journal
Source(s): Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2023 Sep; Vol. 43 (9), pp. 403-413. Date of Electronic Publication: 2023 Jul 27.
Abstract: Type III interferons (IFN-lambdas, IFN-λs) are important antiviral cytokines that can also modulate immune responses by acting through a heterodimeric receptor composed of the specific and limited expressed IFN-λR1 chain and the ubiquitous IL-10R2 chai...
SAMHD1 impairs type I interferon induction through the MAVS, IKKε, and IRF7 signaling axis during viral infection.
Publication Type: Academic Journal
Source(s): The Journal of biological chemistry [J Biol Chem] 2023 Jul; Vol. 299 (7), pp. 104925. Date of Electronic Publication: 2023 Jun 14.
Abstract: Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) restricts human immunodeficiency virus type 1 (HIV-1) infection by reducing the intracellular dNTP pool. We have shown that SAMHD1 suppresses nuclear factor kappa-B activation and type I i...
The role of Type I interferons in the pathogenesis of foot-and-mouth disease virus in cattle: A mathematical modelling analysis.
Publication Type: Academic Journal
Source(s): Mathematical biosciences [Math Biosci] 2023 Sep; Vol. 363, pp. 109052. Date of Electronic Publication: 2023 Jul 24.
Abstract: Type I interferons (IFN) are the first line of immune response against infection. In this study, we explore the interaction between Type I IFN and foot-and-mouth disease virus (FMDV), focusing on the effect of this interaction on epithelial cell death....
Combining PD-1/PD-L1 blockade with type I interferon in cancer therapy.
Publication Type: Academic Journal
Source(s): Frontiers in immunology [Front Immunol] 2023 Aug 24; Vol. 14, pp. 1249330. Date of Electronic Publication: 2023 Aug 24 (Print Publication: 2023).
Abstract: PD-1 and PD-L1 are crucial regulators of immunity expressed on the surface of T cells and tumour cells, respectively. Cancer cells frequently use PD-1/PD-L1 to evade immune detection; hence, blocking them exposes tumours to be attacked by activated T c...
Biological activity of recombinant bovine IFN-α and inhibitory effect on BVDV in vitro.
Publication Type: Academic Journal
Source(s): Microbial pathogenesis [Microb Pathog] 2023 Aug; Vol. 181, pp. 106155. Date of Electronic Publication: 2023 Jun 08.
Abstract: Type I interferon has great broad-spectrum antiviral ability and immunomodulatory function, and its receptors are expressed in almost all types of cells. Bovine viral diarrhea virus (BVDV) is an important pathogen causing significant economic losses in...
Microglia Signaling Pathway Reporters Unveiled Manganese Activation of the Interferon/STAT1 Pathway and Its Mitigation by Flavonoids.
Publication Type: Academic Journal
Source(s): Molecular neurobiology [Mol Neurobiol] 2023 Aug; Vol. 60 (8), pp. 4679-4692. Date of Electronic Publication: 2023 May 04.
Abstract: Neuroinflammatory responses to neurotoxic manganese (Mn) in CNS have been associated with the Mn-induced Parkinson-like syndromes. However, the framework of molecular mechanisms contributing to manganism is still unclear. Using an in vitro neuroinflamm...
Viral recognition and the antiviral interferon response.
Publication Type: Academic Journal
Source(s): The EMBO journal [EMBO J] 2023 Jul 17; Vol. 42 (14), pp. e112907. Date of Electronic Publication: 2023 Jun 27.
Abstract: Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response to viral infections. In response to viral stimuli, cells produce and release interferons, which then act on neighboring cells to induce the transcription of h...
Editorial: Type 1 interferon in pathologies, autoimmune diseases, and chronic viral infections: understanding the fascinating biologic role of type 1 interferons.
Publication Type: Editorial & Opinion
Source(s): Frontiers in immunology [Front Immunol] 2023 Jul 14; Vol. 14, pp. 1239086. Date of Electronic Publication: 2023 Jul 14 (Print Publication: 2023).
Abstract: Competing Interests: The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
NOG1 downregulates type I interferon production by targeting phosphorylated interferon regulatory factor 3.
Publication Type: Academic Journal
Source(s): PLoS pathogens [PLoS Pathog] 2023 Jul 06; Vol. 19 (7), pp. e1011511. Date of Electronic Publication: 2023 Jul 06 (Print Publication: 2023).
Abstract: The innate immune system is the first line of the host's defense, and studying the mechanisms of the negative regulation of interferon (IFN) signaling is important for maintaining the balance of innate immune responses. Here, we found that the host GTP...