Advanced Search Results For "INTERLEUKINS"
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Interleukin-31 Receptor A Expression in the Dorsal Root Ganglion of Mice with Atopic Dermatitis.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jan 05; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 05.
Abstract: Atopic dermatitis (AD) is a common skin disease caused by genetic and environmental factors. However, the mechanisms underlying AD development remain unclear. In this study, we examined the genetic factors contributing to the onset of itch-associated s...
Structural insights into the assembly and activation of the IL-27 signaling complex.
Publication Type: Academic Journal
Source(s): EMBO reports [EMBO Rep] 2022 Oct 06; Vol. 23 (10), pp. e55450. Date of Electronic Publication: 2022 Aug 03.
Abstract: Interleukin 27 (IL-27) is a heterodimeric cytokine that elicits potent immunosuppressive responses. Comprised of EBI3 and p28 subunits, IL-27 binds GP130 and IL-27Rα receptor chains to activate the JAK/STAT signaling cascade. However, how these recepto...
Potentiating adoptive cell therapy using synthetic IL-9 receptors.
Publication Type: Academic Journal
Source(s): Nature [Nature] 2022 Jul; Vol. 607 (7918), pp. 360-365. Date of Electronic Publication: 2022 Jun 08.
Abstract: Synthetic receptor signalling has the potential to endow adoptively transferred T cells with new functions that overcome major barriers in the treatment of solid tumours, including the need for conditioning chemotherapy 1,2 . Here we designed chimeric ...
The emerging role of the neuroimmune cytokine interleukin-31 in chronic inflammatory skin diseases.
Publication Type: Academic Journal
Source(s): Italian journal of dermatology and venereology [Ital J Dermatol Venerol] 2022 Aug; Vol. 157 (4), pp. 306-312. Date of Electronic Publication: 2022 Mar 11.
Abstract: Chronic inflammatory skin diseases pose significant challenges for both patients and clinicians worldwide. Atopic dermatitis (AD), the most common of these diseases, affects up to 8% of the adult population depending on geographic location and demograp...
Interleukin-38 in Health and Disease.
Publication Type: Academic Journal
Source(s): Cytokine [Cytokine] 2022 Apr; Vol. 152, pp. 155824. Date of Electronic Publication: 2022 Feb 24.
The IL-20RB receptor and the IL-20 signaling pathway in regulating host defense in oral mucosal candidiasis.
Publication Type: Academic Journal
Source(s): Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Sep 26; Vol. 12, pp. 979701. Date of Electronic Publication: 2022 Sep 26 (Print Publication: 2022).
Abstract: Pseudomembranous candidiasis (thrush), erythematous candidiasis, and fungal esophagitis are infections of the barrier mucosa of the upper gastrointestinal tract. The majority of these infections are caused by Candida albicans , an opportunistic fungal ...
IL-36 receptor agonist and antagonist imbalance drives neutrophilic inflammation in COPD.
Publication Type: Academic Journal
Source(s): JCI insight [JCI Insight] 2022 Aug 08; Vol. 7 (15). Date of Electronic Publication: 2022 Aug 08.
Abstract: Current treatments fail to modify the underlying pathophysiology and disease progression of chronic obstructive pulmonary disease (COPD), necessitating alternative therapies. Here, we show that COPD subjects have increased IL-36γ and decreased IL-36 re...
Effects of sex and pro-inflammatory cytokines on context discrimination memory.
Publication Type: Academic Journal
Source(s): Behavioural brain research [Behav Brain Res] 2023 Mar 28; Vol. 442, pp. 114320. Date of Electronic Publication: 2023 Jan 30.
Abstract: In learning and memory tasks, immune overactivation is associated with impaired performance, while normal immune activation is associated with optimal performance. In one specific domain of memory, context discrimination memory, peripheral immune stimu...
Butyrate-induced IL-22 expression in fish macrophages contributes to bacterial clearance.
Publication Type: Academic Journal
Source(s): Fish & shellfish immunology [Fish Shellfish Immunol] 2023 Feb; Vol. 133, pp. 108545. Date of Electronic Publication: 2023 Jan 13.
Abstract: IL-22 has been characterized as a critical cytokine in maintaining barrier integrity and host immunity. So far, it has been known that IL-22 is mainly produced by lymphoid lineage cells. In the present study, we have thoroughly investigated butyrate-in...
IL-1Ra gene transfer potentiates BMP2-mediated bone healing by redirecting osteogenesis toward endochondral ossification.
Publication Type: Academic Journal
Source(s): Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2023 Feb 01; Vol. 31 (2), pp. 420-434. Date of Electronic Publication: 2022 Oct 17.
Abstract: An estimated 100,000 patients each year in the United States suffer severe disability from bone defects that fail to heal, a condition where bone-regenerative therapies could provide substantial clinical benefits. Although recombinant human bone morpho...