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Deferiprone and Iron-Maltol: Forty Years since Their Discovery and Insights into Their Drug Design, Development, Clinical Use and Future Prospects.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Mar 04; Vol. 24 (5). Date of Electronic Publication: 2023 Mar 04.
Abstract: The historical insights and background of the discovery, development and clinical use of deferiprone (L1) and the maltol-iron complex, which were discovered over 40 years ago, highlight the difficulties, complexities and efforts in general orphan drug ...
Iron Status and Associated Factors among Canadian Women: Results from the Canadian Health Measures Survey.
Publication Type: Academic Journal
Source(s): The Journal of nutrition [J Nutr] 2023 Mar; Vol. 153 (3), pp. 781-797. Date of Electronic Publication: 2022 Dec 20.
Abstract: Background: Iron deficiency and overload may negatively impact women's health. There has been limited assessment of iron status and its associated factors among Canadian women.Objectives: This study investigated associations of various sociodemographic...
Managing the Dual Nature of Iron to Preserve Health.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Feb 16; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 16.
Abstract: Because of its peculiar redox properties, iron is an essential element in living organisms, being involved in crucial biochemical processes such as oxygen transport, energy production, DNA metabolism, and many others. However, its propensity to accept ...
No difference in myocardial iron concentration and serum ferritin with deferasirox and deferiprone in pediatric patients with hemoglobinopathies: A systematic review and meta-analysis.
Publication Type: Academic Journal
Source(s): Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine [Transfus Clin Biol] 2023 Feb; Vol. 30 (1), pp. 69-74. Date of Electronic Publication: 2022 Jul 22.
Abstract: Objectives: Iron overload is a common complication experienced by transfusion-dependent children with hemoglobin disorders. Chelators such as deferasirox (DFX) and deferiprone (DFP) are effective in overcoming this problem. We conducted this systematic...
Polymorphisms of haptoglobin modify the relationship between dietary iron and the risk of gestational iron-deficiency anemia.
Publication Type: Academic Journal
Source(s): European journal of nutrition [Eur J Nutr] 2023 Feb; Vol. 62 (1), pp. 299-309. Date of Electronic Publication: 2022 Aug 16.
Abstract: Purpose: To assess whether polymorphisms of haptoglobin (Hp) modify the relationship between dietary iron and the risk of gestational iron-deficiency anemia (IDA).Methods: This study analyzed 1430 singleton pregnant women aged 20 ~ ≤ 48 years from the ...
Systematic review and meta-analysis of intravenous iron-carbohydrate complexes in HFrEF patients with iron deficiency.
Publication Type: Academic Journal
Source(s): ESC heart failure [ESC Heart Fail] 2023 Feb; Vol. 10 (1), pp. 44-56. Date of Electronic Publication: 2022 Sep 30.
Abstract: Iron deficiency (ID) is a common co-morbidity in patients with heart failure (HF). The present meta-analysis evaluates the effect of intravenous (IV) iron-carbohydrate complex supplementation in patients with HF with reduced ejection fraction (HFrEF) a...
The role of oral iron in the treatment of adults with iron deficiency.
Publication Type: Academic Journal
Source(s): European journal of haematology [Eur J Haematol] 2023 Feb; Vol. 110 (2), pp. 123-130. Date of Electronic Publication: 2022 Nov 20.
Abstract: Iron deficiency is the most common nutrient deficiency in the world, affecting over 20% of premenopausal women worldwide. Oral iron supplementation is often the first-line treatment for the acute and chronic management of iron deficiency due to its eas...
β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer.
Publication Type: Academic Journal
Source(s): Journal of translational medicine [J Transl Med] 2023 Jan 26; Vol. 21 (1), pp. 50. Date of Electronic Publication: 2023 Jan 26.
Abstract: Background: Although β-catenin signaling cascade is frequently altered in human cancers, targeting this pathway has not been approved for cancer treatment.Methods: High-throughput screening of an FDA-approved drug library was conducted to identify ther...
SARS-CoV-2 Infection Dysregulates Host Iron (Fe)-Redox Homeostasis (Fe-R-H): Role of Fe-Redox Regulators, Ferroptosis Inhibitors, Anticoagulants, and Iron-Chelators in COVID-19 Control.
Publication Type: Academic Journal
Source(s): Journal of dietary supplements [J Diet Suppl] 2023; Vol. 20 (2), pp. 312-371. Date of Electronic Publication: 2022 May 22.
Abstract: Severe imbalance in iron metabolism among SARS-CoV-2 infected patients is prominent in every symptomatic (mild, moderate to severe) clinical phase of COVID-19. Phase-I - Hypoxia correlates with reduced O 2 transport by erythrocytes, overexpression of H...
Prevalence and risk factors for functional iron deficiency in children with chronic kidney disease.
Publication Type: Academic Journal
Source(s): Clinical and experimental nephrology [Clin Exp Nephrol] 2023 Jan; Vol. 27 (1), pp. 66-71. Date of Electronic Publication: 2022 Oct 03.
Abstract: Introduction: Anemia in chronic kidney disease (CKD) is multifactorial. The presence of functional iron deficiency (FID), whereby, there is a block in the transport of iron from macrophage to erythroid marrow is one possible etiology. In this study, we...