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Advanced Search Results For "Inflammation genetics"

1 - 10 of 74,017 results for
 "Inflammation genetics"
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Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human endothelial cells.

Publication Type: Academic Journal

Source(s): Atherosclerosis [Atherosclerosis] 2023 Jan; Vol. 364, pp. 10-19. Date of Electronic Publication: 2022 Nov 23.

Abstract: Background and Aims: Obese patients are at risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). A lipid-rich diet promotes arterial changes by inducing hypertension, oxidative stress, and inflammation. Bromodomain and extratermina...

Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response.

Publication Type: Academic Journal

Source(s): Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2023 Mar 06; Vol. 32 (3), pp. 315-328.

Abstract: Background: Tobacco smoking is an established risk factor for colorectal cancer. However, genetically defined population subgroups may have increased susceptibility to smoking-related effects on colorectal cancer.Methods: A genome-wide interaction scan...

Inflammation and Epigenetic Aging Are Largely Independent Markers of Biological Aging and Mortality.

Publication Type: Academic Journal

Source(s): The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2022 Dec 29; Vol. 77 (12), pp. 2378-2386.


Abstract: Limited evidence exists on the link between inflammation and epigenetic aging. We aimed to (a) assess the cross-sectional and prospective associations of 22 inflammation-related plasma markers and a signature of inflammaging with epigenetic aging and (...

Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice.

Publication Type: Academic Journal

Source(s): Alcohol (Fayetteville, N.Y.) [Alcohol] 2023 Mar; Vol. 107, pp. 136-143. Date of Electronic Publication: 2022 Sep 21.

Abstract: Alcohol use among older adults is on the rise. This increase is clinically relevant as older adults are at risk for increased morbidity and mortality from many alcohol-related chronic diseases compared to younger patients. However, little is known rega...

TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response.

Publication Type: Academic Journal

Source(s): Cell death & disease [Cell Death Dis] 2023 Jan 11; Vol. 14 (1), pp. 14. Date of Electronic Publication: 2023 Jan 11.


Abstract: TP73 is expressed as multiple N- and C-terminal isoforms through two separate promoters or alternative splicing. While N-terminal p73 isoforms have been well studied, very little is known about p73 C-terminal isoforms. Thus, CRISPR was used to delete T...

LincRNA00612 inhibits apoptosis and inflammation in LPS-induced BEAS-2B cells via enhancing interaction between p-STAT3 and A2M promoter.

Publication Type: Academic Journal

Source(s): PeerJ [PeerJ] 2023 Mar 02; Vol. 11, pp. e14986. Date of Electronic Publication: 2023 Mar 02 (Print Publication: 2023).


Abstract: Long non-coding RNAs (lncRNAs) have been reported as key regulators of chronic obstructive pulmonary disease (COPD). This study aimed to figure out the regulatory mechanism as well as the effects of lncRNA00612 (LINC00612) in lipopolysaccharide (LPS)-i...

ANRIL overexpression globally induces expression and alternative splicing of genes involved in inflammation in HUVECs.

Publication Type: Academic Journal

Source(s): Molecular medicine reports [Mol Med Rep] 2023 Feb; Vol. 27 (2). Date of Electronic Publication: 2022 Dec 16.

Abstract: Long non‑coding (lnc)RNAs serve important cellular functions and certain lncRNAs have roles in different mechanisms of gene regulation. lncRNA‑antisense non‑coding RNA in the INK4 locus (ANRIL) affects cell inflammation; however, the potential genes un...

Chronic inflammation decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway.

Publication Type: Academic Journal

Source(s): EMBO reports [EMBO Rep] 2023 Jan 09; Vol. 24 (1), pp. e54729. Date of Electronic Publication: 2022 Nov 07.

Abstract: Chronic inflammation represents a major threat to human health since long-term systemic inflammation is known to affect distinct tissues and organs. Recently, solid evidence demonstrated that chronic inflammation affects hematopoiesis; however, how chr...

Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis.

Publication Type: Academic Journal

Source(s): Stroke [Stroke] 2023 Jan; Vol. 54 (1), pp. 178-188. Date of Electronic Publication: 2022 Dec 01.

Abstract: Background: There are limited data regarding the prevalence of distinct clinical, neuroimaging and genetic markers among patients diagnosed with cerebral amyloid angiopathy-related inflammation (CAA-ri). We sought to determine the prevalence of clinica...

Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae.

Publication Type: Academic Journal

Source(s): Disease models & mechanisms [Dis Model Mech] 2023 Feb 01; Vol. 16 (2). Date of Electronic Publication: 2023 Jan 30.

Abstract: PTPN6 encodes SHP1, a protein tyrosine phosphatase with an essential role in immune cell function. SHP1 mutations are associated with neutrophilic dermatoses and emphysema in humans, which resembles the phenotype seen in motheaten mice that lack functi...