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Advanced Search Results For "LACTATES"

1 - 10 of 116,180 results for
 "LACTATES"
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Development of a novel lactate dehydrogenase A inhibitor with potent antitumor activity and immune activation.

Publication Type:Academic Journal

Source(s):Cancer science [Cancer Sci] 2022 Sep; Vol. 113 (9), pp. 2974-2985. Date of Electronic Publication: 2022 Jul 11.

Abstract:Lactate accumulation in the tumor microenvironment was shown to be closely related to tumor growth and immune escape, and suppression of lactate production by inhibiting lactate dehydrogenase A (LDHA) has been pursued as a potential novel antitumor str...

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Impact of lactate dehydrogenase on prognosis of patients undergoing cardiac surgery.

Publication Type:Academic Journal

Source(s):BMC cardiovascular disorders [BMC Cardiovasc Disord] 2022 Sep 10; Vol. 22 (1), pp. 404. Date of Electronic Publication: 2022 Sep 10.

Abstract:Background: Lactate dehydrogenase (LDH) has been reported in multiple heart diseases. Herein, we explored the prognostic effects of preoperative LDH on adverse outcomes in cardiac surgery patients.Methods: Retrospective data analysis was conducted from...

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Lactate dehydrogenase encapsulated in a metal-organic framework: A novel stable and reusable biocatalyst for the synthesis of D-phenyllactic acid.

Publication Type:Academic Journal

Source(s):Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2022 Aug; Vol. 216, pp. 112604. Date of Electronic Publication: 2022 May 27.

Abstract:In this study, we synthesized a novel biocatalyst by encapsulating lactate dehydrogenase (LDH) in the metal-organic framework ZIF-90 by one-pot embedding. It showed strong biological activity for efficient synthesis of D-phenyllactic acid (D-PLA). The ...

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Lactate dehydrogenase regulates basal glucose uptake in adipocytes.

Publication Type:Academic Journal

Source(s):Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Jun 04; Vol. 607, pp. 20-27. Date of Electronic Publication: 2022 Mar 24.

Abstract:Plasma glucose levels are homeostatically regulated within strict boundaries and are maintained through a balance between peripheral glucose uptake and hepatic glucose production. However, little is known about the regulatory mechanism of glucose uptak...

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Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex.

Publication Type:Academic Journal

Source(s):ELife [Elife] 2022 Jun 24; Vol. 11. Date of Electronic Publication: 2022 Jun 24.

Abstract:Lactate oxidation with NAD + as electron acceptor is a highly endergonic reaction. Some anaerobic bacteria overcome the energetic hurdle by flavin-based electron bifurcation/confurcation (FBEB/FBEC) using a lactate dehydrogenase (Ldh) in concert with t...

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N 6 -methyladenosine-mediated LDHA induction potentiates chemoresistance of colorectal cancer cells through metabolic reprogramming.

Publication Type:Academic Journal

Source(s):Theranostics [Theranostics] 2022 Jun 13; Vol. 12 (10), pp. 4802-4817. Date of Electronic Publication: 2022 Jun 13 (Print Publication: 2022).

Abstract:Background: Chemoresistance to 5-fluorouracil (5-FU) is a major barrier to influence the treatment efficiency of colorectal cancer (CRC) patients, while the precise molecular mechanisms underlying 5-FU resistance remain to be fully elucidated. Methods:...

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Effects of Exogenous ATP on Melanoma Growth and Tumor Metabolism in C57BL/6 Mice.

Publication Type:Academic Journal

Source(s):Comparative medicine [Comp Med] 2022 Apr 01; Vol. 72 (2), pp. 93-103. Date of Electronic Publication: 2022 Apr 11.

Abstract:Altered energy metabolism (glucose, lipid, amino acid) is a hallmark of cancer growth that provides the theoretical basis for the development of metabolic therapies as cancer treatments. ATP is one of the major biochemical constituents of the tumor mic...

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Circ-DONSON Facilitates the Malignant Progression of Gastric Cancer Depending on the Regulation of miR-149-5p/LDHA Axis.

Publication Type:Academic Journal

Source(s):Biochemical genetics [Biochem Genet] 2022 Apr; Vol. 60 (2), pp. 640-655. Date of Electronic Publication: 2021 Aug 18.

Abstract:Earlier studies have shown that circular RNA (circRNA) expression is closely related to the malignant progression of cancer, but the role of circ-DONSON in gastric cancer (GC) has not been fully elucidated. The expression of circ-DONSON, miR-149-5p and...

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Murburn precepts for lactic-acidosis, Cori cycle, and Warburg effect: Interactive dynamics of dehydrogenases, protons, and oxygen.

Publication Type:Academic Journal

Source(s):Journal of cellular physiology [J Cell Physiol] 2022 Mar; Vol. 237 (3), pp. 1902-1922. Date of Electronic Publication: 2021 Dec 20.

Abstract:It is unresolved why lactate is transported to the liver for further utilization within the physiological purview of Cori cycle, when muscles have more lactate dehydrogenase (LDH) than liver. We point out that the answer lies in thermodynamics/equilibr...

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LDHB Overexpression Can Partially Overcome T Cell Inhibition by Lactic Acid.

Publication Type:Academic Journal

Source(s):International journal of molecular sciences [Int J Mol Sci] 2022 May 26; Vol. 23 (11). Date of Electronic Publication: 2022 May 26.

Abstract:Accelerated glycolysis leads to secretion and accumulation of lactate and protons in the tumor environment and determines the efficacy of adoptive T cell and checkpoint inhibition therapy. Here, we analyzed effects of lactic acid on different human CD4...

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